FASEB SRC on Yeast Chromosome Structure, Replication and Segregation

FASEB SRC 关于酵母染色体结构、复制和分离

• 批准号: 8781775
• 负责人: Kathleen L Gould
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-13 至 2015-06-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8781775
• 关键词: Address; Aging; Agreement; Air; American; Animal Model; Area; Behavior; Biochemistry; Biological Factors; Biology; Biophysics; Caring; Cell physiology; Cellular biology; Chromosome Structures; Chromosomes; Collaborations; Colorado; Communities; Complex; Cytology; DNA; Data; Defect; Discipline; Disease; Electromagnetic Energy; Emerging Technologies; Environment; Environmental Risk Factor; Evolution; Feedback; Fission Yeast; Fostering; Gene Expression Profile; Genetic; Genome; Genomics; Goals; Health; Hereditary Disease; Human; Human Genetics; Image; Information Technology; Laboratories; Laboratory Organism; Lead; Malignant Neoplasms; Meiosis; Metabolism; Mission; Molecular; Molecular Biology; National Institute of Environmental Health Sciences; National Institute on Aging; Nicotine; Organism; Participant; Pathology; Play; Postdoctoral Fellow; Premature aging syndrome; Principal Investigator; Process; Proteins; Recording of previous events; Research; Research Personnel; Rewards; Role; Saccharomyces cerevisiae; Saccharomycetales; Scientist; Series; Signal Transduction; Societies; Source; Stress; Systems Biology; Time; Toxic effect; Water; Yeasts; abstracting; age related; base; carcinogenicity; career; cell growth; design; environmental agent; graduate student; innovation; insight; meetings; novel strategies; pollutant; posters; programs; public health relevance; repaired; segregation; single molecule; symposium; transmission process; unpublished works

DESCRIPTION (provided by applicant) This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Yeast Chromosome Structure, Replication, and Segregation to be held July 13-18, 2014 in Steamboat Springs, Colorado. This will be the thirteenth bi-annual iteration of what has become the most successful and important meeting for this field. This conference aims to join investigators studying many diverse aspects of chromosome biology and cell biology in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe, using a range of experimental approaches including genetics, cytology, biochemistry, single molecule imaging, molecular biology, genomics, and systems biology. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited for studies of chromosome biology in more complex experimental organisms and in humans. Environmental agents - including manmade air- and water-borne pollutants, electromagnetic radiation, and nicotine and other natural products - can have profound effects on the replication, segregation, and repair of chromosomes. Moreover, an organism's environment has a strong impact on gene expression patterns. As such, chromosomes are critical targets through which the environment exerts toxic, mutagenic, and carcinogenic effects. The cellular processes that maintain genome integrity in the face of insults from environmental and endogenous sources are thus of fundamental importance for human health and disease. Many critical questions in these areas remain unresolved, and yeasts are outstanding model organisms for addressing these questions because of the evolutionary conservation of many of the molecular mechanisms and proteins involved. Much of the conference will thus be devoted to topics firmly within the mission of the National Institute of Environmental Health Sciences. Changes in chromosome behaviors accompany normal cellular and organismal aging and contribute to age-related pathologies such as chromosome mis-segregation during meiosis, and human genetic diseases associated with aberrant DNA metabolism are often accompanied by hallmarks of premature aging. Yeasts have long played a dominant role in studies of the fundamental mechanisms underlying normal and pathological chromosome dynamics, thus the topics covered in this conference also support the missions of the National Institute on Aging.

描述（由申请人提供） 本申请寻求对将于2014年7月13日至18日在科罗拉多的汽船泉举行的美国实验生物学学会联合会（FASEB）关于酵母染色体结构、复制和分离的会议的部分支持。这将是该领域最成功和最重要的会议的第十三次半年度迭代。本次会议的目的是加入研究人员研究染色体生物学和细胞生物学的许多不同方面的芽殖酵母酿酒酵母和裂殖酵母粟酒裂殖酵母，使用一系列的实验方法，包括遗传学，细胞学，生物化学，单分子成像，分子生物学，基因组学和系统生物学。演讲将介绍关于该领域及时问题的新的和未发表的工作，并将包括所有与会者的讨论。FASEB会议为信息和技术的交流提供了独特的机会，这些信息和技术可以用于更复杂的实验生物体和人类的染色体生物学研究。 环境因素--包括人造空气和水传播污染物、电磁辐射、尼古丁和其他天然产品--可能对染色体的复制、分离和修复产生深远影响。此外，生物体的环境对基因表达模式有很大的影响。因此，染色体是环境发挥毒性、致突变和致癌作用的关键目标。因此，在面对来自环境和内源性来源的损害时保持基因组完整性的细胞过程对于人类健康和疾病具有根本重要性。这些领域的许多关键问题仍未解决，酵母是解决这些问题的杰出模式生物，因为许多分子机制和相关蛋白质的进化保守性。因此，会议的大部分时间将致力于国家环境健康科学研究所使命范围内的主题。染色体行为的变化伴随着正常的细胞和生物体衰老，并导致与年龄相关的病理学，如减数分裂期间的染色体错误分离，与异常DNA代谢相关的人类遗传疾病通常伴随着过早衰老的标志。酵母长期以来在正常和病理染色体动力学的基本机制研究中发挥着主导作用，因此本次会议所涵盖的主题也支持国家老龄化研究所的使命。