Small Animal Cone Beam CT Guided X-Irradiation System (SARRP)

小动物锥形束 CT 引导 X 射线照射系统 (SARRP)

• 批准号: 8640441
• 负责人: BO LU
• 金额: $ 59.99万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2016-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640441
• 关键词: Advisory Committees; Animal Experimentation; Animals; Cancer Center; Cellular biology; Chemistry; Clinic; Clinical; Discipline of Nuclear Medicine; Environment; Fees; Flow Cytometry Shared Resource; Funding; Grant; Human; Image; Immunology; Laboratories; Medical; Methods; Modeling; Molecular; Mus; Neoplasm Metastasis; Normal tissue morphology; Physics; Radiation; Radiation Oncology; Radiation Physics; Radiation therapy; Radiobiology; Radiology Specialty; Radiopharmaceuticals; Rattus; Recording of previous events; Research; Research Personnel; Services; Structure; System; Technology; Therapeutic; Translational Research; Treatment Protocols; United States National Institutes of Health; Universities; X-Ray Computed Tomography; base; clinical practice; cone-beam computed tomography; instrument; instrumentation; irradiation; medical schools; millimeter; new technology; oncology; operation; pre-clinical research; preclinical study; prototype; quantum; tool; treatment planning; tumor

DESCRIPTION (provided by applicant): This S10 shared instrumentation grant will fund the purchase of a Cone Beam CT Guided Small Animal Radiation Research Platform (SARRP), manufactured by Gulmay Medical, Inc., Suwanee, GA. There is a critical need for this machine, which is a preclinical research tool for studies on small animals (mice and rats) that can model the exposures given to humans in therapeutic settings. Although the technology for clinical radiation therapy has advanced significantly in the past 25 years, the methods for radiation delivery in a laboratory setting have lagged behind. Modern radiotherapy uses image guidance to deliver highly conformal radiation to a target volume while sparing normal tissue structures. By contrast, methods used in animal research to irradiate spontaneous or orthotopic tumors and their metastases are guided by external features alone, and generally expose a large portion of the body to radiation. The SARRP offers a powerful new technology for preclinical studies in translational radiation biology. The SARRP is portable, with on-board cone beam CT imaging (0.25-0.5 mm voxel size) to guide radiation delivery. It can deliver highly conformal radiation to target volumes with sub-millimeter accuracy. As such, it can precisely irradiate animals with a level of precision that approaches current clinical practice. Sparing normal tissue is essential as we move towards hypofractionated treatment schedules to pilot approaches to bring to the clinic. The SARRP irradiator is based on the prototype developed by Dr. John Wong, Director of Radiation Physics, Johns Hopkins University. Dr. Wong's instrument has been in use for seven years, and there are 17 more in service in the USA and elsewhere. Dr. Wong will serve as a consultant for our group. Administration of the instrument will be by the PI, the Co-Investigator for Medical Physics and the Co-investigator for Radiation Oncology/Radiation Biology. Assisting the Administration is an Internal Advisory Committee with demonstrated expertise in radiation biology (PI), medical physics, radiation oncology, experimental oncology, nuclear medicine/ radiopharmaceutical chemistry (Director of the Small Animal Imaging Facility) and cell biology/immunology (Director of the Kimmel Cancer Center Shared Resources for Flow Cytometry & Cs-137 Irradiation). The Division of Molecular Radiation Biology is one of the more active radiation biology groups in the USA with a strong emphasis on translational research. The Medical Physics Division has expertise in conformal and stereotactic treatment planning, online image fusion and setup correction, which directly supports use of this high-end irradiator. Funds to support operation of the machine will come from the Administration of the University, the Medical College Administration, the Kimmel Cancer Center and the Department of Radiation Oncology and from user fees. We have 20 NIH-funded users and five users with non-NIH research funding. Jefferson has a long history of academic radiology, radiation oncology and radiation biology. The acquisition of this state-of-the-art machine will allow for a quantum leap forward for our translational radiation oncology research environment.

描述（由申请人提供）：这项S10共享仪器拨款将资助购买锥束CT引导小动物辐射研究平台（SARRP），该平台由Gulmay Medical， Inc, Suwanee， GA制造。这台机器是一种临床前研究工具，用于小动物（小鼠和大鼠）的研究，可以模拟人类在治疗环境中的暴露。虽然在过去的25年里，临床放射治疗的技术有了很大的进步，但在实验室环境中进行放射治疗的方法却落后了。现代放射治疗使用图像引导，在保留正常组织结构的同时，向目标体积提供高度适形的辐射。相比之下，动物研究中用于照射自发或原位肿瘤及其转移的方法仅以外部特征为指导，并且通常将身体的很大一部分暴露在辐射下。SARRP为转化辐射生物学的临床前研究提供了强有力的新技术。SARRP是便携式的，带有机载锥束CT成像（0.25-0.5 mm体素大小）来指导辐射输送。它可以以亚毫米精度向目标体积提供高度适形辐射。因此，它可以精确地以接近当前临床实践的精度水平照射动物。保留正常组织是必不可少的

项目成果

PD-1 Modulates Radiation-Induced Cardiac Toxicity through Cytotoxic T Lymphocytes.

PD-1通过细胞毒性T淋巴细胞调节辐射诱导的心脏毒性。

• DOI: 10.1016/j.jtho.2017.12.002
• 发表时间: 2018-04
• 期刊: JOURNAL OF THORACIC ONCOLOGY
• 影响因子: 20.4
• 作者: Du, Shisuo;Zhou, Lin;Alexander, Gregory S.;Park, Kyewon;Yang, Lifeng;Wang, Nadan;Zaorsky, Nicholas G.;Ma, Xinliang;Wang, Yajing;Dicker, Adam P.;Lu, Bo
• 通讯作者: Lu, Bo

Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer.

• DOI: 10.1016/j.ijrobp.2016.07.008
• 发表时间: 2016-11-01
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Du S;Lockamy V;Zhou L;Xue C;LeBlanc J;Glenn S;Shukla G;Yu Y;Dicker AP;Leeper DB;Lu Y;Lu B
• 通讯作者: Lu B