Brain Imaging Markers of Response to Intervention in Toddlers with Autism

自闭症幼儿干预反应的脑成像标志物

• 批准号: 8710347
• 负责人: Jason J Wolff
• 金额: $ 4.03万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2014-08-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710347
• 关键词: Address; Aftercare; Age-Months; Amygdaloid structure; Area; Autistic Disorder; Behavior; Behavior Therapy; Behavioral; Bilateral; Brain; Brain imaging; Brain region; Child; Child Development; Cognitive; Collaborations; Data; Development; Developmental Disabilities; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Early Intervention; Enrollment; Fostering; Funding; Goals; Grant; Heterogeneity; Home environment; Image; Image Analysis; Individual; Individual Differences; Infant; Inferior; Institutes; Intervention; Intervention Studies; Journals; Knowledge; Learning; Link; Measurement; Measures; Mediating; Mediator of activation protein; Mentors; Neurobiology; Neurosciences; North Carolina; Occipital lobe; Outcome; Pattern; Performance; Postdoctoral Fellow; Preparation; Property; Qualifying; Randomized Controlled Trials; Reading; Research; Risk; Sampling; Science; Scientist; Special Education; Temporal Lobe; Thick; Toddler; Training; Universities; autism spectrum disorder; base; brain behavior; career; career development; communication behavior; experience; frontal lobe; improved; joint attention; medical specialties; neurobehavioral; neuroimaging; predictive modeling; public health relevance; relating to nervous system; response; response marker; skills; social communication; symposium; treatment response

DESCRIPTION (provided by applicant): This proposed Mentored Research Scientist CDA (K01) seeks support to foster an independent research career bridging the study of brain development in children with autism spectrum disorder (ASD) to that of early intervention. The developing brain is highly malleable, and interventions which capitalize on this quality hold great promise. However, response to intervention is variable and dependent on individual differences, an issue compounded by ASD heterogeneity. Linking traditionally separate lines of intervention and neurobehavioral research has the potential to aid efforts to optimally individualize intervention. In the short term, the candidate's career goals include identifying early brain-behavior markers of behavioral outcomes and treatment response. In the longer term, the candidate plans to leverage this information to develop targeted early interventions. The candidate is trained in special education, behavior analysis, and developmental neuroscience. To achieve the goal of developing neurobehaviorally informed interventions, the candidate will engage in new and comprehensive training in intervention science with a focus on early intervention for autism, new training in structural brain imaging analysis, and additional statistical and methodological training. Activities supporting these content areas include hands-on training, coursework, journal clubs and directed readings, specialty conference and institute participation, and professional development seminars, with training culminating in the preparation of an R01 grant. The candidate will also investigate brain imaging predictors of: 1) joint attention in toddlers with ASD and 2) response to intervention for joint attention. In the fist study, the candidate will examine concurrent and predictive imaging markers of joint attention in an existing longitudinal sample of toddlers with ASD. In the second study, the candidate will collect pre-treatment imaging data on ~45 toddlers with ASD enrolled in a funded RCT for joint attention intervention to indentify neural mediators of dimensional outcomes, and conduct an exploratory analysis of differences between high- and low-responders. The University of North Carolina is an active center of autism research. Primary mentor Dr. Joseph Piven is a leading expert in the neurobiology of ASD and has extensive experience mentoring junior scientists. He is Director of the Carolina Institute for Developmental Disabilities (CIDD) and PI of the ACE Network Infant Brain Imaging Study. Co-mentor Dr. Samuel Odom is an accomplished expert in early intervention for ASD. He is Director of the Frank Porter Graham Child Development Institute and PI of many early intervention studies. UNC is home to world-class imaging facilities and experts, including co-mentor Dr. Martin Styner, an expert in structural image analysis and Co-Director of both the Neuro Image Research and Analysis Lab and the CIDD's Developmental Neuroimaging Core. Together, this mentor team is superbly qualified to provide the candidate with training, guidance, and oversight in development activities bridging brain, behavior, and intervention.

描述（由申请人提供）：这个拟议的指导研究科学家CDA（K01）寻求支持，以促进独立的研究事业，将自闭症谱系障碍（ASD）儿童的大脑发育研究与早期干预联系起来。发育中的大脑具有高度的可塑性，利用这种特性的干预措施具有很大的优势。 保证然而，对干预的反应是可变的，取决于个体差异，ASD异质性加剧了这个问题。将传统上独立的干预措施和神经行为研究联系起来，有可能有助于最佳个性化干预的努力。在短期内，候选人的职业目标包括识别行为结果和治疗反应的早期大脑行为标记。从长远来看，候选人计划利用这些信息来制定有针对性的早期干预措施。 候选人接受特殊教育，行为分析和发育神经科学的培训。为了实现开发神经行为知情干预的目标，候选人将参与干预科学的新的和全面的培训，重点是自闭症的早期干预，结构脑成像分析的新培训，以及额外的统计和方法培训。支持这些内容领域的活动包括实践培训，课程，期刊俱乐部和定向阅读，专业会议和研究所的参与，以及专业发展研讨会，培训最终在R01赠款的准备。候选人还将研究大脑成像预测：1）ASD幼儿的联合注意力和2）对联合注意力干预的反应。在第一项研究中，候选人将在现有的ASD幼儿纵向样本中检查联合注意力的并发和预测性成像标记。在第二项研究中，候选人将收集约45名ASD幼儿的治疗前成像数据，这些幼儿参加了一项资助的RCT，进行联合注意力干预，以识别维度结果的神经介质，并对高应答者和低应答者之间的差异进行探索性分析。 北卡罗来纳州大学是一个活跃的自闭症研究中心。主要导师Joseph Piven博士是ASD神经生物学方面的领先专家，在指导初级科学家方面拥有丰富的经验。他是卡罗莱纳发育障碍研究所（CIDD）的主任和ACE网络婴儿脑成像研究的PI。联合导师Samuel Odom博士是自闭症谱系障碍早期干预方面的资深专家。他是弗兰克·波特·格雷厄姆儿童发展研究所的主任，也是许多早期干预研究的PI。芝加哥拥有世界一流的成像设施和专家，包括共同导师Martin Styner博士，他是结构图像分析专家，也是神经图像研究和分析实验室以及CIDD发育神经成像核心的共同主任。总之，这个导师团队非常有资格为候选人提供培训，指导和监督发展活动，连接大脑，行为和干预。