Acquisition of a Cryoprobe for a 600 MHz NMR Spectrometer

获取用于 600 MHz NMR 波谱仪的冷冻探针

• 批准号: 8639823
• 负责人: MICHELLE KROGSGAARD
• 金额: $ 35.97万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639823
• 关键词: Binding; Biological Sciences; Biology; Biomedical Research; Chemicals; Chemistry; Detection; Disease; Equipment; Funding; Funding Applicant; Grant; Health; Housing; Human; Methodology; National Center for Research Resources; New York; Research Personnel; Sampling; Solutions; Technology; United States National Institutes of Health; Universities; cryogenics; instrumentation; medical schools; meetings; research facility; research study; structural biology

DESCRIPTION (provided by applicant): Funds are requested to acquire a cryogenic probe for a 600 MHz NMR spectrometer to support chemical biology and biomedical research efforts across New York University (NYU), including the Department of Chemistry and the School of Medicine. The equipment will be housed in the Shared Instrumentation Facility for Life Science in the Department of Chemistry. This facility was built with support from the NIH/NCRR in the form of a Research Facilities Improvement Grant. The proposed cryogenic probe will support nine NIH funded users and will provide technology currently not available at NYU (i.e., no cryoprobe on campus). The cryogenic probe will include highly sensitive 1H and 13C detection (increase of 3-4-fold) with the ability to perform all triple resonance experiments needed to characterize the structural dynamics of biomacromolecules using state-of- the-art solution NMR methodology. This equipment will also allow researchers limited in sample mass to carry out sensitive structural studies. NYU has a partial membership at the New York Structural Biology Center that is insufficient to meet the NMR needs of the NIH-funded researchers at NYU. Therefore, having a cryogenic probe on campus will facilitate increased access to this technology that will be essential to revealing molecular interactions important in human health and disease.

描述（由申请人提供）：需要资金购买用于 600 MHz NMR 波谱仪的低温探针，以支持纽约大学 (NYU) 的化学生物学和生物医学研究工作，包括化学系和医学院。该设备将安置在化学系生命科学共享仪器设施中。该设施是在 NIH/NCRR 以研究设施改进补助金的形式支持下建造的。拟议的低温探针将支持九名 NIH 资助的用户，并将提供纽约大学目前不可用的技术（即校园内没有冷冻探针）。低温探针将包括高度灵敏的 1H 和 13C 检测（增加 3-4 倍），能够使用最先进的溶液 NMR 方法进行表征生物大分子结构动力学所需的所有三重共振实验。该设备还将使研究人员能够在样品质量有限的情况下进行敏感的结构研究。纽约大学在纽约结构生物学中心拥有部分会员资格，但不足以满足 NIH 资助的纽约大学研究人员的 NMR 需求。因此，在校园内安装低温探测器将有助于增加对这项技术的使用，这对于揭示对人类健康和疾病至关重要的分子相互作用至关重要。

项目成果

Synthesis of Enantiopure Triols from Racemic Baylis-Hillman Adducts Using a Diastereoselective Peroxidation Reaction.

使用非映选择性过氧化反应从外星人贝利斯 - 希尔曼加合物中的对映体三醇合成。

• DOI: 10.1021/acs.orglett.0c03439
• 发表时间: 2020-11-20
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Zuckerman DS;Woerpel KA
• 通讯作者: Woerpel KA

Total Synthesis of (±)-Exotine B.

• DOI: 10.1021/acs.orglett.8b01817
• 发表时间: 2018-07-20
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Cheng B;Volpin G;Morstein J;Trauner D
• 通讯作者: Trauner D

Cobalt-Catalyzed Oxygenation/Dearomatization of Furans.

钴催化呋喃的氧化/脱芳构化。

• DOI: 10.1021/acs.joc.8b01183
• 发表时间: 2018
• 期刊: The Journal of organic chemistry
• 作者: Oswald,JonathanP;Woerpel,KA
• 通讯作者: Woerpel,KA