Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD自成立以来已经进入了NIEHS的第九个年头。在过去的一年里，Fessler博士被授予NIH校内研究项目的终身职位。 自上次年度报告以来的出版物包括： 1)一份合作报告显示免疫相关的GTP酶Irgm 1在细胞内的定位受其被脂肪酸棕榈酸酯修饰的控制（亨利等人，PLoS One. 2014年4月21日;9（4）：e95021）。 2)资深作者的报告显示肿瘤抑制因子p53和转录因子NF-κ B协同诱导原代人巨噬细胞中的促炎细胞因子（Lowe等，2014年4月15日;74（8）：2182-92）。 3)共同第一作者的报告显示载脂蛋白E调节小鼠模型中急性肺损伤的发展（Yamashita等，呼吸。2014;87（5）：416-27）。 4)一位资深作者的报告显示，人基因APOE（即，APOE 4）的R14等位基因与人中升高的炎症反应有关（Gale等，2014年7月;134（1）：127-134.e9）。 5)一份合作报告显示胆固醇转运蛋白ABCG 1控制巨噬细胞上细胞外胆固醇结构域的产生，这是一项与胆固醇转运相关的发现（Freeman等，2014年1月;55（1）：115-27）。 6)关于低密度脂蛋白对中性粒细胞功能的急性和慢性作用的合作报告（PalvinskayaT等，Pulm Pharmacol Ther 2013）。 7)第一作者报道，在美国公民中，血清胆固醇与红细胞指数（例如，血细胞比容）和血小板指数（例如，血小板计数）相关（Fessler等人，2013年11月;54（11）：3177-88）。 8)一位资深作者报道清道夫受体B-I调节肺宿主对感染的防御（Gowdy等，Mucobacterium Immunology 2014，in press）。 自我们上次报告以来的其他成就包括Fessler博士在NIH细胞因子兴趣小组炎症脂质介体会议（2014年），国家咨询环境健康科学理事会第142次会议上的特邀演讲，以及NC协会的Rx科学素养研讨会。Fessler博士还在2014年美国胸科学会国际会议上担任海报会议主持人。 自上次报告以来，Fesslers博士的几名学员也获得了奖项/认可，包括博士后研究员Kymberly Gowdy（第二名，博士后研究员海报竞赛，访问肺部学者研讨会，星期五中心; 2014年ATS国际会议上的口头报告）和研究生Michael亨德森（研究生最佳海报报告，毒理学课程）。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its ninth year at the NIEHS since inception. During the past year, Dr. Fessler was granted tenure in the NIH intramural research program. Publications since the last annual report include: 1) a collaborative report showing that the localization inside cells of the immunity related GTPases Irgm1 is controlled by its modification with the fatty acid palmitate (Henry et al., PLoS One. 2014 Apr 21;9(4):e95021). 2) a senior-author report showing the the tumor suppressor p53 and the transcription factor NF-kB cooperate to induce pro-inflammatory cytokines in primary human macrophages (Lowe et al., Cancer Res. 2014 Apr 15;74(8):2182-92). 3) a co-first author report showing that apolipoprotein E regulates the development of acute lung injury in a mouse model (Yamashita et al., Respiration. 2014;87(5):416-27). 4) a senior author report showing that the epsilon 4 allele of the human gene APOE (ie, APOE4) associates with heightened inflammatory responses in humans (Gale et al., J Allergy Clin Immunol. 2014 Jul;134(1):127-134.e9). 5) a collaborative report showing that the cholesterol transporter ABCG1 controls generation of extracellular cholesterol domains on macrophages, a finding relevant to cholesterol transport(Freeman et al., J Lipid Res. 2014 Jan;55(1):115-27). 6) a collaborative report on the acute and chronic effects of low-density lipoprotein on neutrophil function (Palvinskaya T et al., Pulm Pharmacol Ther 2013). 7) a first-author report that serum cholesterol has a relationship to indices of erythrocytes (eg, hematocrit) and platelets (eg, platelet count) among U.S. citizens (Fessler et al., J Lipid Res. 2013 Nov;54(11):3177-88). 8) a senior author report that scavenger receptor B-I regulates pulmonary host defense against infection (Gowdy et al., Mucosal Immunology 2014, in press). Additional accomplishments since our last report include invited talks by Dr. Fessler at the NIH Cytokine Interest Group Lipid Mediators in Inflammation Meeting (2014), the 142nd meeting of the National Advisory Environmental Health Sciences Council, and the Rx for Science Literacy Workshop of the NC Assoc. for Biomedical Research. Dr. Fessler also served as a poster session facilitator at the 2014 American Thoracic Society International Conference. Several of Dr. Fesslers trainees also received awards/recognition since the last report, including postdoctoral fellow Kymberly Gowdy (Second Place, Postdoctoral Fellow Poster Competition, Visiting Pulmonary Scholars Symposium, UNC Friday Center; oral presentation at 2014 ATS International Conference), and graduate student Michael Henderson (Best Poster Presentation from Graduate Student, UNC Toxicology Curriculum).