Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD现在进入了NIEHS的第14个年头。自上次年度报告以来的出版物包括： 1.一篇关于慢性肾脏疾病中巨噬细胞先天免疫的合作综述文章 2.关于蛋白质溶质载体家族37成员2（SCL 37 A2）在巨噬细胞炎症和细胞代谢中的作用的合作报告 3.关于胆固醇25-羟化酶在肺部炎症消退中的作用的资深作者出版物 4.关于microRNA-33在抗病毒宿主防御中的作用的特邀社论 5.关于慢性阻塞性肺疾病基于呼吸机的定义的有效性的合作报告 6.先天性免疫受体TLR 5在环境诱导的肺损伤中的作用的合作报告 7.一份关于巨噬细胞自噬在小鼠动脉粥样硬化中作用的合作报告 8.一份描述双酚A替代品（双酚F和S）与人类哮喘和花粉热相关性的合作报告 9.一份高级作者报告描述了瑞舒伐他汀对血清胆固醇正常的志愿者免疫系统的影响 10.一个资深作者的出版物，描述了上皮细胞膜蛋白2在控制中性粒细胞进入感染肺中的新作用。 自我们上一份报告以来的其他成就包括Fesslers博士获得NIH董事挑战创新奖，以表彰他提出的创建跨NIH代谢组学和脂质组学联盟以协调和推进校内代谢组学研究的建议。Fessler博士还被任命为佛蒙特州肺中心外部咨询计划的成员，并参加了今年夏天早些时候VLC的虚拟务虚会，为他们的研究计划提供专家反馈。 Fessler博士继续担任《美国呼吸细胞和分子生物学杂志》的副主编。 Fessler博士和他的学员在过去一年的几次会议上以口头报告和海报的形式介绍了他们的研究成果。 此外，Fesslers博士的两名博士后研究员Wan-Chi Lin博士和Prashant Rai博士获得了NIH优秀研究员奖。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its 14th year at the NIEHS. Publications since the last annual report include: 1. a collaborative review article on macrophage innate immunity in chronic kidney disease 2. a collaborative report on the role of the protein Solute Carrier Family 37 Member 2 (SCL37A2) in macrophage inflammation and cellular metabolism 3. a senior-author publication on the role of the enzyme cholesterol 25-hydroxylase in resolution of lung inflammation 4. an invited editorial on the role of microRNA-33 in antiviral host defense 5. a collaborative report on the validity of questionnaire-based definitions for chronic obstructive lung disease 6. a collaborative report on the role of innate immune receptor TLR5 in environment-induced lung injury 7. a collaborative report on the role of autophagy in macrophages in atherosclerosis in mice 8. a collaborative report describing the association of bisphenol A substitutes (bisphenols F and S) with asthma and hay fever in humans 9. a senior author report describing the effect of rosuvastatin on the immune system of volunteers who have normal serum cholesterol 10. a senior author publication describing a novel role for Epithelial Membrane Protein 2 in the control of neutrophil entry into the infected lung. Additional accomplishments since our last report include Dr. Fesslers receipt of the NIH Directors Challenge Innovation Award for his proposal to create a Trans-NIH Metabolomics and Lipidomics Consortium to coordinate and advance intramural metabolomics studies. Dr. Fessler was also appointed member of the Vermont Lung Center External Advisory Program and attended a virtual retreat of the VLC earlier this summer to provide them with expert feedback on their research program. Dr. Fessler has continued his work as Associate Editor for the American Journal of Respiratory Cell and Molecular Biology. Dr. Fessler and his trainees presented their research findings, in the form of oral presentations and posters, at several meetings over the past year. In addition, two of Dr. Fesslers postdoctoral fellows, Drs. Wan-Chi Lin and Prashant Rai, received NIH Fellows Awards for Research Excellence.