Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD现在进入了NIEHS的第17个年头。自上次年度报告以来的出版物包括： 1. 一份鉴定与晚发性哮喘相关的MHC基因座遗传变异的合作报告 2. 关于胆固醇生物合成在小鼠颅神经嵴细胞生物学中作用的合作报告 3. 一份资深作者报告确定了25-羟基胆固醇在小鼠和人类肺损伤中的重要作用 4. 一份关于COVID-19患者肺部细胞单细胞RNA测序数据的荟萃分析的资深作者报告，确定了肺泡上皮细胞的新变化。 5. 一份确定巨噬细胞炎症生物学中白藜芦醇作用的合作报告 6. 关于使用NHANES将机器学习方法应用于加权调查数据的合作报告 7. 一份合作报告，确定距离猪饲养操作与免疫介导疾病的关联 8. 使用肺泡生物标志物识别不同类型急性呼吸窘迫综合征患者的合作报告 自我们上次报告以来的其他成就包括Fessler博士应邀在ENDO 2023（内分泌学会会议）、哥德堡大学第三届小气道和PEXA会议、ACR会聚和杜克大学肺大圆桌会议上发表口头演讲。 Fessler博士还继续担任美国呼吸细胞和分子生物学杂志的副主编。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its 17th year at the NIEHS. Publications since the last annual report include: 1. A collaborative report identifying genetic variants of the MHC locus associated with late-onset asthma 2. A collaborative report on the role of cholesterol biosynthesis in murine cranial neural crest cell biology 3. A senior-author report identifying an important role for 25-hydroxycholesterol in lung injury in mice and humans 4. A senior-author report of a meta-analysis of single cell-RNA sequencing data of cells from COVID-19 patient lungs, identifying novel changes in alveolar epithelial cells. 5. A collaborative report identifying roles for prohibitins in macrophage inflammatory biology 6. A collaborative report on application of machine learning methods to weighted survey data, using NHANES 7. A collaborative report identifying associations of distance to swine feeding operations with immune-mediated diseases 8. A collaborative report using alveolar biomarkers to identify different types of patients who have acute respiratory distress syndrome Additional accomplishments since our last report include Dr. Fessler's invited oral presentations at ENDO 2023 (Endocrine Society meeting), at the Third Conference on Small Airways and PExA at University of Gothenburg, at ACR Convergence, and at Duke University Pulmonary Grand Rounds. Dr. Fessler has also continued his work as Associate Editor for the American Journal of Respiratory Cell and Molecular Biology.