Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD自成立以来已经进入了NIEHS的第十个年头。 自上次年度报告以来的出版物包括： 1. 一位资深作者报道，microRNA-33通过改变质膜脂筏微区中的胆固醇水平来调节巨噬细胞炎症信号的强度（Pubmed ID 27471270）。 2. 一份合作报告显示，microRNA-33也在碳纳米管引起的肺部疾病中发挥作用，并可能在肺部疾病结节病中发挥作用（Pubmed ID 26641802） 3. 一份报告称，接受瑞舒伐他汀（一种HMG CoA还原酶抑制剂）治疗的人类志愿者的高密度脂蛋白中的蛋白质谱发生了变化;这可能需要增强HDL相关蛋白的抗炎功能（Pubmed ID 26483418） 4. 一篇关于脂质在肺部感染和炎症中作用的特邀综述文章（Pubmed ID 27286794） 5. 一篇关于表面活性剂脂质在炎症和感染性肺病中作用的特邀综述文章（Pubmed ID 26859434） 6. 一篇关于胆固醇合成途径对宿主防御的影响的特邀评论文章（Pubmed ID 26758950） 7. 一篇关于胆固醇代谢在控制适应性免疫反应中的作用的特邀综述文章（Pubmed ID 26149587） 8. 对Am J Respir Crit Care Med发表的一篇报告的特邀评论，该报告描述了血清脂蛋白与哮喘之间的新关系（Pubmed ID 25932757） 自我们上次报告以来的其他成就包括Fessler博士在蒙大拿州汉密尔顿落基山实验室的特邀演讲;杜克大学先天免疫研讨会（主旨发言人）;维克森林大学微生物学和免疫学系;国立犹太医院肺部分部; NIH免疫学兴趣小组研讨会系列;以及国立犹太医院的蛋白质组学和代谢组学研讨会。 此外，Fessler博士在2016年美国胸科学会国际会议上主持了一个关于肺部炎症的科学研讨会。Fesslers博士的学员还通过旅行和抽象奖得到了认可。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its tenth year at the NIEHS since inception. Publications since the last annual report include: 1. a senior author report that microRNA-33 regulates the strength of inflammatory signaling by macrophages by changing cholesterol levels in lipid raft microdomains of the plasma membrane (Pubmed ID 27471270) 2. a collaborative report showing that microRNA-33 also plays a role in lung disease caused by carbon nanotubes and may play a role in the lung disease sarcoidosis (Pubmed ID 26641802) 3. a report that human volunteers treated with rosuvastatin, an HMG CoA reductase inhibitor, have a changed profile of proteins in their high density lipoproteins; this may need to enhanced anti-inflammatory function of the HDL-associated proteins (Pubmed ID 26483418) 4. an invited review article on the role of lipids in pulmonary infections and inflammation (Pubmed ID 27286794) 5. an invited review article on the role of surfactant lipids in inflammatory and infectious lung diseases (Pubmed ID 26859434) 6. an invited review article on effects of the cholesterol synthesis pathway on host defense (Pubmed ID 26758950) 7. an invited review article on the role of cholesterol metabolism in controlling adaptive immune responses (Pubmed ID 26149587) 8. an invited editorial commentary on a published report in Am J Respir Crit Care Med that describes novel relationships between serum lipoproteins and asthma (Pubmed ID 25932757) Additional accomplishments since our last report include invited talks presented by Dr. Fessler at Rocky Mountain Laboratories in Hamilton, MT; the Duke University Innate Immunity Symposium (keynote speaker); the Department of Microbiology and Immunology of Wake Forest University; the Pulmonary Division of National Jewish Hospital; the NIH Immunology Interest Group Seminar Series; and at a Proteomics & Metabolomics Workshop at National Jewish Hospital. In addition, Dr. Fessler chaired a scientific symposium on lung inflammation at the 2016 American Thoracic Society International Conference. Dr. Fesslers trainees were also recognized through travel and abstract awards.