2014 Chemistry & Biology of Tetrapyyroles Gordon Research Conference

2014级化学

• 批准号: 8783141
• 负责人: John Dearborn Phillips
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8783141
• 关键词: Anabolism; Animals; Area; Bacterial Infections; Bilin; Biochemistry; Biological Factors; Biological Models; Biology; Biophysics; Bioremediations; Biotechnology; Cell Respiration; Cells; Chemistry; Chlorophyll; Clinical; Cobalamin; Coenzymes; Collaborations; Complex; Confidentiality; DNA biosynthesis; Data; Discipline; Disease; Engineering; Ensure; Environment; Enzymes; Erythropoiesis; Evolution; Fertilization; Fostering; Goals; Health; Heme; Hereditary Disease; Homeostasis; Human; Knowledge; Lead; Learning; Life; Medical; Metabolism; Metals; Microbiology; Mission; Molecular; Parasitic infection; Participant; Pathway interactions; Photochemotherapy; Photosynthesis; Physicians; Planets; Plants; Play; Porphyrias; Process; Production; Public Health; Research; Research Personnel; Role; Schedule; Scientist; Tetrapyrroles; Time; Translational Research; United States National Institutes of Health; Vitamin B 12; Work; chemical synthesis; cofactor; corrin; design; graduate student; human disease; improved; interest; meetings; planetary Atmosphere; posters; programs; public health relevance; repaired; small molecule; success; symposium; trafficking

DESCRIPTION (provided by applicant): All major life processes such as photosynthesis, aerobic respiration, methanogenesis and DNA synthesis are dependent upon essential roles played by modified tetrapyrroles such as chlorophylls, hemes, coenzyme F430 and cobalamins (vitamin B12). These cofactors of life not only represent some of the colourful compounds on the planet but are also some of the most complex small molecules made in cells. The 2014 GRC on the Chemistry and Biology of Tetrapyrroles will provide a stimulating forum for the presentation and discussion of cutting edge advances on hemes, chlorophylls, bilins, corrins (vitamin B12) and other related cofactors of life. The conference will feature a wide range of topics including medical aspects associated with tetrapyrrole metabolism and trafficking, the biosynthesis of these natural products, the chemical synthesis of derivative and model systems, and the industrial application of these molecules for bioenergy, bioremediation and photodynamic therapy. The conference will bring together biochemists, microbiologists, chemists and physicians at the forefront of their fields, providing many opportunities for junior scientists and graduate students to discuss their research and exchange ideas via poster sessions and informal meetings. Some poster presenters will be selected for talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. The meeting will include sessions on recent advances in tetrapyrrole synthesis/function, their role in health and disease, how these molecules are made and broken down, the roles they play in the environment, the interplay with metal homeostasis, their evolution, their delivery and repair and the role they are likely to play in synthetic biolog. The sessions will give delegates a chance to understand how enzymes work cooperatively within pathways to ensure the efficient and controlled production of tetrapyrroles, gain first hand knowledge of what goes wrong when these pathway are derailed as with human diseases such as the porphyrias, and learn how these conditions can be controlled. It will provide a unique platform for scientists from many backgrounds to understand how chemistry can be used to inform our knowledge of these molecules, how they can be tailored to selectively interfere with specific molecular processes and how all of this knowledge can be applied in the design and redesign of biology for useful purposes. The conference environment will stimulate such cross fertilization of ideas, allowing clinicians to talk to chemists and engineers to ecologists under a tetrapyrrole umbrella. There will be a significant focus on the integration and participation of young researchers who are helping to provide many of the new exciting breakthrough ideas in this area.

描述（由申请人提供）：所有主要的生命过程，例如光合作用，有氧呼吸，甲烷生成和DNA合成均取决于修饰的四吡咯，例如叶绿素，Hemes，Coenzyme F430和Cobalamins和钴胺（Vitamin b12）所扮演的基本角色。这些生命的辅助因子不仅代表了地球上的某些彩色化合物，而且是细胞中制成的一些最复杂的小分子。 2014年关于四吡咯的化学和生物学的GRC将为刺激性论坛提供刺激性的论坛，以介绍和讨论尖端的前沿进展，叶绿素，bilins，corrins，corrins（维生素B12）和其他相关的生命辅助因子。该会议将包括各种主题，包括与四吡咯代谢和贩运相关的医学方面，这些天然产物的生物合成，衍生物和模型系统的化学合成以及这些分子在生物增强作用，生物化和光动力疗法中的工业应用。该会议将汇集生物化学家，微生物学家，化学家和医生在其领域的最前沿，为初级科学家和研究生提供许多机会，通过海报会议和非正式会议讨论他们的研究和交流思想。一些海报演示者将被选为谈判。本次会议的合作氛围，在下午和晚上进行了计划的讨论会以及非正式聚会的机会，为从不同学科的科学家到头脑风暴，并促进了代表的各种研究领域的跨学科合作。这次会议将包括有关四吡咯合成/功能的最新进展，其在健康和疾病中的作用，如何制作和分解这些分子的作用，它们在环境中扮演的角色，与金属稳态的相互作用，其演变，其递送和修复以及它们在合成生物学中可能起着的作用。这些会议将使代表有机会了解酶如何在途径中合作工作以确保四吡咯的高效和受控产生，并获得第一手的收益 了解这些途径与人类疾病（如卟啉症）一样出轨时出了问题，并了解如何控制这些情况。它将为来自许多背景的科学家提供一个独特的平台，以了解如何使用化学来告知我们对这些分子的了解，如何量身定制它们以选择性地干扰特定的分子过程，以及如何将所有这些知识应用于生物学的设计和重新设计中，以实现有用的目的。会议环境将刺激这种思想的交叉施肥，使临床医生能够与化学家和工程师与生态学家交谈 四吡咯伞。年轻的研究人员将有很大的重点关注的年轻研究人员的融合和参与，他们正在帮助提供许多新的令人兴奋的突破性想法。