2014 Chemistry & Biology of Tetrapyyroles Gordon Research Conference

2014级化学

• 批准号: 8783141
• 负责人: John Dearborn Phillips
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8783141
• 关键词: Anabolism; Animals; Area; Bacterial Infections; Bilin; Biochemistry; Biological Factors; Biological Models; Biology; Biophysics; Bioremediations; Biotechnology; Cell Respiration; Cells; Chemistry; Chlorophyll; Clinical; Cobalamin; Coenzymes; Collaborations; Complex; Confidentiality; DNA biosynthesis; Data; Discipline; Disease; Engineering; Ensure; Environment; Enzymes; Erythropoiesis; Evolution; Fertilization; Fostering; Goals; Health; Heme; Hereditary Disease; Homeostasis; Human; Knowledge; Lead; Learning; Life; Medical; Metabolism; Metals; Microbiology; Mission; Molecular; Parasitic infection; Participant; Pathway interactions; Photochemotherapy; Photosynthesis; Physicians; Planets; Plants; Play; Porphyrias; Process; Production; Public Health; Research; Research Personnel; Role; Schedule; Scientist; Tetrapyrroles; Time; Translational Research; United States National Institutes of Health; Vitamin B 12; Work; chemical synthesis; cofactor; corrin; design; graduate student; human disease; improved; interest; meetings; planetary Atmosphere; posters; programs; public health relevance; repaired; small molecule; success; symposium; trafficking

DESCRIPTION (provided by applicant): All major life processes such as photosynthesis, aerobic respiration, methanogenesis and DNA synthesis are dependent upon essential roles played by modified tetrapyrroles such as chlorophylls, hemes, coenzyme F430 and cobalamins (vitamin B12). These cofactors of life not only represent some of the colourful compounds on the planet but are also some of the most complex small molecules made in cells. The 2014 GRC on the Chemistry and Biology of Tetrapyrroles will provide a stimulating forum for the presentation and discussion of cutting edge advances on hemes, chlorophylls, bilins, corrins (vitamin B12) and other related cofactors of life. The conference will feature a wide range of topics including medical aspects associated with tetrapyrrole metabolism and trafficking, the biosynthesis of these natural products, the chemical synthesis of derivative and model systems, and the industrial application of these molecules for bioenergy, bioremediation and photodynamic therapy. The conference will bring together biochemists, microbiologists, chemists and physicians at the forefront of their fields, providing many opportunities for junior scientists and graduate students to discuss their research and exchange ideas via poster sessions and informal meetings. Some poster presenters will be selected for talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. The meeting will include sessions on recent advances in tetrapyrrole synthesis/function, their role in health and disease, how these molecules are made and broken down, the roles they play in the environment, the interplay with metal homeostasis, their evolution, their delivery and repair and the role they are likely to play in synthetic biolog. The sessions will give delegates a chance to understand how enzymes work cooperatively within pathways to ensure the efficient and controlled production of tetrapyrroles, gain first hand knowledge of what goes wrong when these pathway are derailed as with human diseases such as the porphyrias, and learn how these conditions can be controlled. It will provide a unique platform for scientists from many backgrounds to understand how chemistry can be used to inform our knowledge of these molecules, how they can be tailored to selectively interfere with specific molecular processes and how all of this knowledge can be applied in the design and redesign of biology for useful purposes. The conference environment will stimulate such cross fertilization of ideas, allowing clinicians to talk to chemists and engineers to ecologists under a tetrapyrrole umbrella. There will be a significant focus on the integration and participation of young researchers who are helping to provide many of the new exciting breakthrough ideas in this area.

描述（由申请人提供）：所有主要的生命过程，如光合作用、有氧呼吸、甲烷生成和DNA合成，都依赖于修饰的四吡咯，如叶绿素、血红素、辅酶F430和维生素B12所起的重要作用。这些生命的辅因子不仅代表了地球上一些色彩缤纷的化合物，也是细胞中最复杂的小分子。2014年关于四吡咯的化学和生物学的GRC将为血红素，叶绿素，胆色素，可林（维生素B12）和其他相关的生命辅助因子的前沿进展的介绍和讨论提供一个刺激的论坛。会议将讨论广泛的主题，包括与四吡咯代谢和贩运相关的医学方面，这些天然产物的生物合成，衍生物和模型系统的化学合成，以及这些分子在生物能源，生物修复和光动力治疗中的工业应用。会议将汇集生物化学家，微生物学家，化学家和医生在各自领域的最前沿，为年轻的科学家和研究生提供了许多机会，通过海报会议和非正式会议讨论他们的研究和交流思想。部分海报主持人将被选中参加讲座。本次会议的合议气氛，与程序化的讨论会，以及在下午和晚上的非正式聚会的机会，为来自不同学科的科学家提供了一个渠道，集思广益，并促进跨学科的合作，在各个研究领域的代表。会议将包括四吡咯合成/功能的最新进展，它们在健康和疾病中的作用，这些分子如何制造和分解，它们在环境中的作用，与金属稳态的相互作用，它们的进化，它们的交付和修复以及它们可能在合成生物学中发挥的作用。会议将使代表们有机会了解酶如何在途径中协同工作，以确保四吡咯的有效和可控生产， 当这些途径如卟啉症等人类疾病脱轨时会出现什么问题的知识，并学习如何控制这些条件。它将为来自许多背景的科学家提供一个独特的平台，以了解化学如何用于告知我们对这些分子的知识，如何定制它们以选择性地干扰特定的分子过程，以及如何将所有这些知识应用于生物学的设计和重新设计。会议环境将刺激这种思想的交叉施肥，使临床医生与化学家和工程师，生态学家在一个 四吡咯伞。将有一个显着的重点是年轻研究人员的整合和参与，他们正在帮助提供许多新的令人兴奋的突破性想法在这一领域。