2014 Chemistry & Biology of Tetrapyyroles Gordon Research Conference

描述(由申请人提供)：所有主要的生命过程，如光合作用、有氧呼吸、产甲烷和DNA合成，都依赖于修饰的四个角色所发挥的基本作用，如叶绿素、血红素、辅酶F430和钴胺(维生素B12)。这些生命的辅因子不仅代表了地球上一些五颜六色的化合物，而且也是一些在细胞中制造的最复杂的小分子。2014年四角化学和生物学GRC将提供一个激动人心的论坛，介绍和讨论在血红素、叶绿素、胆红素、考林素(维生素B12)和其他相关生命辅助因素方面的前沿进展。会议主题广泛，包括与四吡咯代谢和贩运有关的医学方面，这些天然产物的生物合成，衍生物和模型系统的化学合成，以及这些分子在生物能源、生物修复和光动力疗法方面的工业应用。这次会议将汇聚各自领域前沿的生物化学家、微生物学家、化学家和内科医生，为初级科学家和研究生提供许多机会，通过海报会议和非正式会议讨论他们的研究并交流想法。一些海报主持人将被选为演讲嘉宾。这次会议气氛热烈，有计划的讨论会议以及在下午和晚上举行非正式聚会的机会，为来自不同学科的科学家提供了集思广益的途径，并促进了所代表的不同研究领域的跨学科合作。会议将包括四吡咯合成/功能的最新进展，它们在健康和疾病中的作用，这些分子是如何制造和分解的，它们在环境中扮演的角色，它们与金属动态平衡的相互作用，它们的进化，它们的传递和修复，以及它们在合成生物学中可能发挥的作用。这些会议将使代表们有机会了解酶如何在途径内协同工作，以确保四聚吡咯的高效和受控生产，获得第一手资料 了解当这些途径脱轨时会出现什么问题，就像人类的疾病一样，并学习如何控制这些情况。它将为来自不同背景的科学家提供一个独特的平台，让他们了解如何利用化学来了解我们对这些分子的知识，如何对它们进行定制，以选择性地干扰特定的分子过程，以及如何将所有这些知识应用于生物学的设计和重新设计中，以达到有用的目的。会议环境将刺激这种思想的交叉培养，允许临床医生与化学家和工程师在一种 四色伞。将把重点放在年轻研究人员的整合和参与上，他们帮助在这一领域提供许多令人兴奋的新突破想法。

DESCRIPTION (provided by applicant): All major life processes such as photosynthesis, aerobic respiration, methanogenesis and DNA synthesis are dependent upon essential roles played by modified tetrapyrroles such as chlorophylls, hemes, coenzyme F430 and cobalamins (vitamin B12). These cofactors of life not only represent some of the colourful compounds on the planet but are also some of the most complex small molecules made in cells. The 2014 GRC on the Chemistry and Biology of Tetrapyrroles will provide a stimulating forum for the presentation and discussion of cutting edge advances on hemes, chlorophylls, bilins, corrins (vitamin B12) and other related cofactors of life. The conference will feature a wide range of topics including medical aspects associated with tetrapyrrole metabolism and trafficking, the biosynthesis of these natural products, the chemical synthesis of derivative and model systems, and the industrial application of these molecules for bioenergy, bioremediation and photodynamic therapy. The conference will bring together biochemists, microbiologists, chemists and physicians at the forefront of their fields, providing many opportunities for junior scientists and graduate students to discuss their research and exchange ideas via poster sessions and informal meetings. Some poster presenters will be selected for talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. The meeting will include sessions on recent advances in tetrapyrrole synthesis/function, their role in health and disease, how these molecules are made and broken down, the roles they play in the environment, the interplay with metal homeostasis, their evolution, their delivery and repair and the role they are likely to play in synthetic biolog. The sessions will give delegates a chance to understand how enzymes work cooperatively within pathways to ensure the efficient and controlled production of tetrapyrroles, gain first hand knowledge of what goes wrong when these pathway are derailed as with human diseases such as the porphyrias, and learn how these conditions can be controlled. It will provide a unique platform for scientists from many backgrounds to understand how chemistry can be used to inform our knowledge of these molecules, how they can be tailored to selectively interfere with specific molecular processes and how all of this knowledge can be applied in the design and redesign of biology for useful purposes. The conference environment will stimulate such cross fertilization of ideas, allowing clinicians to talk to chemists and engineers to ecologists under a tetrapyrrole umbrella. There will be a significant focus on the integration and participation of young researchers who are helping to provide many of the new exciting breakthrough ideas in this area.