Late Transition Metal Catalysts for Organic Synthesis

说明（由申请人提供）：官能化分子的可用性在有机和药物化学领域以及制药和相关工业中具有突出的重要性。不仅化合物应该是可获得的，而且容易和可预测地修饰它们以改变它们的性质和/或消除副作用的手段也具有巨大的意义。在本授权申请中提出的化学涉及发明或强调技术，以获得含有碱性氮中心作为关键结构特征的分子。我们之前在这一领域的工作已被纳入合成有机化学家的日常工作中，并极大地影响了有机合成领域，特别是在制药行业的药物发现方面。此外，我们提出了对映体纯（单手）形式的各种各样的胺从非常简单的（烯烃）前体的合成工作。基本上所有现代小分子药物现在都必须以单手形式出售，并且成功完成这一壮举可能会增加药剂的成本。还包括制备氮杂环的新方法。在许多方面，这种类型的化合物构成了制药工业的支柱。我们还建议对所包括的所有化学物质进行机理研究。此外，从这项工作中获得的信息将有助于理解正在开发的过程的机制，以提高我们正在开发的方法的效率。总的来说，成功实现本拨款申请中提出的化学将对化学家和辅助领域的化学家开发新的医学重要性，传感器或生物相关性的能力产生重大影响。 将推动科学进步的化合物和材料。

DESCRIPTION (provided by applicant): The availability of functionalized molecules is of preeminent importance in the fields of organic and medicinal chemistry and to the pharmaceutical and related industries. Not only should compounds be accessible, but also the means to readily and predictably modify them to change their properties and/or eliminate side effects is of tremendous significance. The chemistry that is proposed in this grant application involves the invention or accentuation of techniques to access molecules that contain basic nitrogen centers as key structural features. Our prior work in this field has been incorporated into the everyday repertoire of synthetic organic chemists and has greatly impacted the field of organic synthesis, particularly in drug discovery in the pharmaceutical industry. In addition, we are proposing work on the synthesis in enantiomerically pure (single handed) form of a wide variety of amines from extremely simple (alkene) precursors. Essentially all modern small molecule medicines must now be sold in single-handed forms and the successful accomplishment of this feat can add to the cost of the medicinal agent. Also included are new methods for the preparation of nitrogen heterocycles. In many ways, compounds of this type form the backbone of the pharmaceutical industry. We also propose to carry out mechanistic studies on all of the chemistry included. Further, information gained from this work will help to understand the mechanism of the processes that are being developed in order to increase the efficiency of the methods that we are developing. Overall, the successful realization of the chemistry proposed in this grant application will have a major impact on the ability of chemists and those in auxiliary fields to develop new medicinally important, sensor or biologically relevant compounds and materials that will move science forward.