2013 Kern Lipid Conference

2013年科恩脂质会议

• 批准号: 8597637
• 负责人: MOSHE LEVI
• 金额: $ 1万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597637
• 关键词: Academia; Adipocytes; Adipose tissue; Animal Model; Animals; Area; Atherosclerosis; Award; Basic Science; Biochemistry; Biology; Biotechnology; Cells; Cholesterol; Chronic; Colorado; Complex; Development; Disease; Doctor of Philosophy; Dyslipidemias; Ensure; Faculty; Fatty Acids; Fostering; Functional disorder; Gene Expression; Genetic Transcription; Glycerides; Goals; Health; Human; Immune; Industry; Inflammation; Investigation; Learning; Lipids; Lipolysis; Lipoproteins; Liver; Medical center; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Minority; Modification; Molecular; Molecular Genetics; Myocardium; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pharmacologic Substance; Phospholipids; Physiology; Postdoctoral Fellow; Proteins; Regulation; Regulatory Pathway; Research; Research Personnel; Resort; Science; Scientist; Stress; Texas; Time; Translational Research; Universities; Woman; base; career; cholesterol trafficking; design; graduate student; insulin sensitivity; interest; lectures; lipid metabolism; meetings; member; novel; novel strategies; nutrition; posters; prevent; professor; programs; protein function; public health relevance; small molecule; symposium; transcription factor; uptake

DESCRIPTION (provided by applicant): The Kern Lipid Conference, which was first convened in 1985 and continues to be held annually, explores the complex interplay between lipid metabolism and chronic human disorders such as cardio-metabolic diseases, dyslipidemia, atherosclerosis, and type II diabetes. The overall goals of the Kern Lipid Conference are to: 1) ensure at least 25 percent of meeting participants are early career scientists (graduate students, postdoctoral fellows, and Assistant Professors); 2) promote science relating to broad areas of lipid and lipoprotein metabolism; 3) increase understanding of the pathobiology of dyslipidemia; 4) provide an open forum for scientists from both academia and industry to meet and discuss latest research findings related to lipid metabolism; and 5) to provide a unique meeting format in which 50 percent of the time is devoted to formal presentations and 50 percent is for open discussions of the presentations. The 2013 Kern Lipid Conference, entitled "Molecular Mechanisms and Pathophysiology of Lipid Storage,"will be held July 29 - August 1, 2013 at the Vail Cascade Resort in Vail, CO. The Conference will be co- chaired by Dawn L. Brasaemle, Ph.D. (Rutgers University) and Russell DeBose-Boyd, Ph.D. (University of Texas Southwestern Medical Center). Several aspects related to metabolism and storage of neutral lipids will be examined, including mechanisms for lipid droplet formation and dissolution, the relationships between lipid metabolism and inflammation, health effects and consequences of ectopic (non-adipose) lipid storage, adipose control of insulin sensitivity, mechanisms through which cholesterol, fatty acids, and other lipids regulate gene expression, and how modulation of transcription factors alters lipid uptake and metabolism. The speakers are internationally recognized experts in these topics and employ a variety of experimental approaches ranging from investigations of basic molecular mechanisms to studies of animal and human physiology. The program described in this application will emphasize in-depth discussion of these presentations, which will provide an impetus for development of novel strategies and therapies to prevent the aberrant accumulation of lipids that underlies many of the human disorders of interest to the Kern Lipid Conference. Importantly, the meeting continues to be a scientific agenda that encourages the attendance and participation of early career scientists in the Conference, enabling them to discuss research on a one- on-one basis with highly established scientists.

描述（由申请人提供）：克恩脂质会议于1985年首次召开，并继续每年举行一次，探讨脂质代谢与慢性人类疾病（如心脏代谢疾病、血脂异常、动脉粥样硬化和II型糖尿病）之间的复杂相互作用。克恩脂质会议的总体目标是：1）确保至少25%的与会者是早期职业科学家（研究生，博士后研究员和助理教授）; 2）促进与脂质和脂蛋白代谢的广泛领域有关的科学; 3）增加对血脂异常的病理生物学的理解; 4）为学术界及工业界的科学家提供一个公开论坛，让他们会面及讨论有关脂质代谢的最新研究成果; 5）提供一种独特的会议形式，其中50%的时间用于正式报告，50%用于公开讨论报告。2013年克恩脂质会议，题为“脂质储存的分子机制和病理生理学“，将于2013年7月29日至8月1日在韦尔瀑布度假村在韦尔，CO。会议将共同主持黎明L。Brasaemle，博士（罗格斯大学）和Russell DeBose-Boyd博士德克萨斯大学西南医学中心（University of Texas Southwestern Medical Center）本文将探讨中性脂质代谢和储存的几个方面，包括脂滴形成和溶解的机制，脂质代谢与炎症的关系，异位妊娠对健康的影响和后果。（非脂肪）脂质储存，胰岛素敏感性的脂肪控制，胆固醇、脂肪酸和其它脂质调节基因表达的机制，以及转录因子的调节如何改变脂质摄取和代谢。演讲者是这些主题的国际公认专家，并采用各种实验方法，从基本分子机制的研究到动物和人类生理学的研究。本申请中描述的计划将强调对这些演讲的深入讨论，这将为开发新的策略和疗法提供动力，以防止脂质的异常积累，这是克恩脂质会议感兴趣的许多人类疾病的基础。重要的是，会议仍然是一个科学议程，鼓励早期职业科学家出席和参与会议，使他们能够与知名科学家一对一地讨论研究。