2013 Kern Lipid Conference

描述(申请人提供)：Kern Lipid Conference于1985年首次召开，并将继续每年举行一次，探讨脂代谢和慢性人类疾病之间复杂的相互作用，如心脏代谢性疾病、血脂异常、动脉粥样硬化和II型糖尿病。科恩脂类会议的总体目标是：1)确保至少25%的与会者是早期职业科学家(研究生、博士后研究员和助理教授)；2)促进与脂类和脂蛋白代谢广泛领域相关的科学；3)增加对血脂紊乱的病理生物学的了解；4)为来自学术界和工业界的科学家提供一个开放的论坛，以开会和讨论与脂类代谢有关的最新研究成果；以及5)提供独特的会议形式，其中50%的时间用于正式陈述，50%的时间用于对陈述的公开讨论。2013年Kern Lipid大会将于2013年7月29日至8月1日在科罗拉多州Vail的Vail Cascade Resort举行，主题为“脂肪储存的分子机制和病理生理学”。会议将由罗格斯大学的Dawn L.Brasaemle博士和德克萨斯大学西南医学中心的Russell DeBose-Boyd博士共同主持。与中性脂的代谢和储存有关的几个方面将被研究，包括脂滴形成和溶解的机制，脂代谢与炎症之间的关系，异位(非脂肪)脂储存对健康的影响和后果，脂肪对胰岛素敏感性的控制，胆固醇、脂肪酸和其他脂类调节基因表达的机制，以及转录因子如何调节脂类的吸收和代谢。演讲者是这些主题的国际公认的专家，并采用了各种实验方法，从基本分子机制的研究到动物和人类生理学的研究。本申请中描述的计划将强调对这些演示的深入讨论，这将为开发新的策略和疗法提供动力，以防止脂类的异常积累，这是克恩脂肪会议感兴趣的许多人类疾病的基础。重要的是，会议仍然是一项科学议程，鼓励早期职业科学家出席和参与会议，使他们能够与知名科学家一对一地讨论研究问题。

DESCRIPTION (provided by applicant): The Kern Lipid Conference, which was first convened in 1985 and continues to be held annually, explores the complex interplay between lipid metabolism and chronic human disorders such as cardio-metabolic diseases, dyslipidemia, atherosclerosis, and type II diabetes. The overall goals of the Kern Lipid Conference are to: 1) ensure at least 25 percent of meeting participants are early career scientists (graduate students, postdoctoral fellows, and Assistant Professors); 2) promote science relating to broad areas of lipid and lipoprotein metabolism; 3) increase understanding of the pathobiology of dyslipidemia; 4) provide an open forum for scientists from both academia and industry to meet and discuss latest research findings related to lipid metabolism; and 5) to provide a unique meeting format in which 50 percent of the time is devoted to formal presentations and 50 percent is for open discussions of the presentations. The 2013 Kern Lipid Conference, entitled "Molecular Mechanisms and Pathophysiology of Lipid Storage,"will be held July 29 - August 1, 2013 at the Vail Cascade Resort in Vail, CO. The Conference will be co- chaired by Dawn L. Brasaemle, Ph.D. (Rutgers University) and Russell DeBose-Boyd, Ph.D. (University of Texas Southwestern Medical Center). Several aspects related to metabolism and storage of neutral lipids will be examined, including mechanisms for lipid droplet formation and dissolution, the relationships between lipid metabolism and inflammation, health effects and consequences of ectopic (non-adipose) lipid storage, adipose control of insulin sensitivity, mechanisms through which cholesterol, fatty acids, and other lipids regulate gene expression, and how modulation of transcription factors alters lipid uptake and metabolism. The speakers are internationally recognized experts in these topics and employ a variety of experimental approaches ranging from investigations of basic molecular mechanisms to studies of animal and human physiology. The program described in this application will emphasize in-depth discussion of these presentations, which will provide an impetus for development of novel strategies and therapies to prevent the aberrant accumulation of lipids that underlies many of the human disorders of interest to the Kern Lipid Conference. Importantly, the meeting continues to be a scientific agenda that encourages the attendance and participation of early career scientists in the Conference, enabling them to discuss research on a one- on-one basis with highly established scientists.