Diffusion tensor imaging of the injured spinal cord

受损脊髓的弥散张量成像

基本信息

项目摘要

DESCRIPTION (provided by applicant): ABSTRACT Hypothesis: We hypothesize the diffusion properties and microstructure change across the entire length of the spinal cord during recovery from SCI. Also, we postulate that diffusion measurements and tissue sparing can be used to estimate sensorimotor function. In addition, we hypothesize that DTI is sensitive to regenerative interventions. Preliminary Data: Pilot studies have demonstrated the feasibility of obtaining DTI images of the injured and non-injured rat spinal cord using a high field (9.4T) small animal magnet. DTI images appear to follow expected patterns predicted by images obtained in chronic human SCI, with changes in diffusivity both at the injury site and in regions distant from the injury. Of particular note, reductions in diffusion appear in regions o fthe spinal cord distant from the injury site that correlate with histological data indicating cellular responses in neurons ofthe corresponding gray matter. Further, pilot data indicate that diffusion patterns are related to functional connectivity of the spinal cord, evidenced by correlations with spinal somatosensory evoked potentials (SSEPs). In separate studies, we have also demonstrated specific structural changes in the cervical dorsal hom of the rat spinal cord subjected to thoracic contusion injury and treated with stem cell grafts. These structural changes correlated with increased proliferation of pain fibers, which functionally resulted in the development of forelimb allodynia. We propose using this treatment paradigm, with well documented structural and functional changes, to test the diagnostic and prognostic abilities of DTI. Research Objectives: The overall goal of this project is to determine whether DTI can provide a non invasive imaging correlate of spinal cord structure and function following injury and regenerative therapies in a rat model of SCI. We plan to pursue this goal through three specific objectives. (1) Characterize region-specific changes in diffusivity during recovery from SCI. (2) Characterize functional correlates to DTI in the spinal cord during recovery from SCI. (3) Determine the sensitivity ofDTI to neuronal stem cell treatments following SCI. Our approach will use in vivo and ex vivo OTI to detemi.ine histological correlates during recovery from SCI. We will then determine the behavioral and electrophysiological functional correlates to DTI to histology and axonal morphometry. Lastly, we will determine the sensitivity of DTI to regeneration interventions with known changes in structure and function. The translational nature of this project is reflected by direct future application in humans if DTI is found to be able to detect histologically verifiable changes in morphology in the injured spinal cord.
Please try later.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Shekar N. Kurpad其他文献

The challenge of recruitment for neurotherapeutic clinical trials in spinal cord injury
脊髓损伤神经治疗临床试验招募的挑战
  • DOI:
    10.1038/s41393-019-0276-2
  • 发表时间:
    2019-04-08
  • 期刊:
  • 影响因子:
    2.200
  • 作者:
    Andrew R. Blight;Jane Hsieh;Armin Curt;James W. Fawcett;James D. Guest;Naomi Kleitman;Shekar N. Kurpad;Brian K. Kwon;Daniel P. Lammertse;Norbert Weidner;John D. Steeves
  • 通讯作者:
    John D. Steeves
The Use of Magnetic Resonance Imaging by Spine Surgeons in Management of Spinal Trauma Across AO Regions–Results of AO Spine Survey
  • DOI:
    10.1016/j.wneu.2020.01.200
  • 发表时间:
    2020-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Mayank Kaushal;Saman Shabani;Hesham M. Soliman;Ha Son Nguyen;Bizhan Aarabi;Michael G. Fehlings;Mark R. Kotter;Brian K. Kwon;James S. Harrop;Shekar N. Kurpad
  • 通讯作者:
    Shekar N. Kurpad

Shekar N. Kurpad的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Shekar N. Kurpad', 18)}}的其他基金

Stimulation of Cervical Excitatory Interneurons to Restore Breathing After Chronic Cervical Spinal Cord Injury
刺激颈部兴奋性中间神经元以恢复慢性颈髓损伤后的呼吸
  • 批准号:
    10531878
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Stimulation of Cervical Excitatory Interneurons to Restore Breathing After Chronic Cervical Spinal Cord Injury
刺激颈部兴奋性中间神经元以恢复慢性颈髓损伤后的呼吸
  • 批准号:
    10360818
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Advanced MRI of Spinal Cord Injury
脊髓损伤的高级 MRI
  • 批准号:
    10731352
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Advanced MRI of Spinal Cord Injury
脊髓损伤的高级 MRI
  • 批准号:
    10356042
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Advanced MRI of Spinal Cord Injury
脊髓损伤的高级 MRI
  • 批准号:
    9900574
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Fusion Flow Cytometer and Cell Sorter
ShEEP 请求融合流式细胞仪和细胞分选仪
  • 批准号:
    9210823
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
Diffusion Tensor Imaging of the Injured Spinal Cord
损伤脊髓的弥散张量成像
  • 批准号:
    8783631
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Diffusion tensor imaging of the injured spinal cord
受损脊髓的弥散张量成像
  • 批准号:
    7888248
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Diffusion tensor imaging of the injured spinal cord
受损脊髓的弥散张量成像
  • 批准号:
    7748471
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:

相似国自然基金

Behavioral Insights on Cooperation in Social Dilemmas
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    万元
  • 项目类别:
    外国优秀青年学者研究基金项目

相似海外基金

CAREER: Early-life social environments drive behavioral and neural mechanisms of development
职业:早期社会环境驱动行为和神经机制的发展
  • 批准号:
    2341006
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
NSF PRFB FY 2023: Assessing morphological, behavioral, and genetic impacts of methylmercury on spiders.
NSF PRFB 2023 财年:评估甲基汞对蜘蛛的形态、行为和遗传影响。
  • 批准号:
    2305949
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship Award
A mobile health solution in combination with behavioral change approach to improve vaccination coverage and timeliness in Bangladesh: A cluster randomized control trial
移动健康解决方案与行为改变方法相结合,以提高孟加拉国的疫苗接种覆盖率和及时性:集群随机对照试验
  • 批准号:
    24K20168
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The role of nigrostriatal and striatal cell subtype signaling in behavioral impairments related to schizophrenia
黑质纹状体和纹状体细胞亚型信号传导在精神分裂症相关行为障碍中的作用
  • 批准号:
    10751224
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
CAREER:HCC: Using Virtual Reality Gaming to Develop a Predictive Simulation of Human-Building Interactions: Behavioral and Emotional Modeling for Public Space Design
职业:HCC:使用虚拟现实游戏开发人类建筑交互的预测模拟:公共空间设计的行为和情感建模
  • 批准号:
    2339999
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
ICE-TI: A Decolonized Approach to an AAS in Social and Behavioral Sciences
ICE-TI:社会和行为科学中 AAS 的非殖民化方法
  • 批准号:
    2326751
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Differentiating innate and conditioned fear in behavioral level using pupillometry and neural level using brain-wide traveling wave
使用瞳孔测量法区分行为水平上的先天性恐惧和条件性恐惧,并使用全脑行波区分神经水平上的先天性恐惧和条件性恐惧
  • 批准号:
    23K28389
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Bilingualism as a cognitive reserve factor: the behavioral and neural underpinnings of cognitive control in bilingual patients with aphasia
双语作为认知储备因素:双语失语症患者认知控制的行为和神经基础
  • 批准号:
    10824767
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
Collaborative Research: Behavioral Science and the Making of the Right-Reasoning Public Health Citizenry
合作研究:行为科学与正确推理的公共卫生公民的培养
  • 批准号:
    2341512
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Collaborative Research: Behavioral Science and the Making of the Right-Reasoning Public Health Citizenry
合作研究:行为科学与正确推理的公共卫生公民的培养
  • 批准号:
    2341513
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了