Clinical Core

C-Sig临床核心的目标是提供用户友好的一站式服务，以访问消化系统 为中心成员提供与疾病相关的生物制品。在丽莎·博德曼博士的指导下，一位著名的 具有IRB和生物库专业知识的临床医生科学家、CSIG的组织和基础设施 临床核心提供必要的专业知识和人员，为C-Sig成员提供建议和互动 追求两个具体目标：第一，提供支持，以加强现有的与Gl有关的单个生物库 在临床核心保护伞内运营，并开发未来的知识库。第二，集中，加快， 并为C-Sig成员访问Gl相关生物库和使用Gl生物质谱库提供便利 在人类样本的范例中翻译信号研究。为实现这些目标，C-Sig临床 核心：一)为生物检疫申请提供一个中央接入点和简化程序；二)加强 现有的Gl组织生物储存库通过促进新的标本收集，以及，iii)开发新的组织 收藏。核心整合了来自#司个人调查员的现有资源。 胃肠病学和肝病学，以及来自机构生物检疫库，提供成本效益 协作性地将G1信号范例翻译到人体组织的方法。此外，C-Sig 临床核心与1R6，解剖病理冰冻切片建立了强大的合作伙伴关系 实验室(又名TRIG；所有外科生物显微镜的来源)和病理学研究中心(设施 进行组织切片、免疫染色等)。这些合作伙伴关系使C-Sig临床核心人员能够 通过这些关键机构资源加快议定书和项目的行动。主要服务 C-Sig临床核心提供的是IR6协议开发支持、生物样品请求支持 (包括识别适当的组织、病理检查和协调组织处理)；以及 生物库支持服务(IR6协议模板、组织库存管理软件，标准化 问卷调查，每天搜索手术清单，以获得批准的1R6方案，以及有限的研究协调员 支持同意)。为了回应C-Sig成员的反馈，我们最近增加了服务 支持收集人类微生物组研究的粪便。C-Sig临床核心服务有 已被63%的中心成员使用，并支持了49种出版物。

The objective of the C-SiG Clinical Core is to provide a user-friendly, one-stop service to access digestive disease-related biospecimens for Center members. Under the direction of Dr. Lisa Boardman, a well-established clinician scientist with IRB and biobanking expertise, the organization and infrastructure of the CSiG Clinical Core provides essential expertise and personnel to advise and interact with C-SiG members in pursuit of two Specific Aims: First, to provide support to enhance existing individual Gl-related biobanks operating within the Clinical Core umbrella and develop future repositories. Second, to centralize, expedite, and facilitate access to Gl-related biobanks and utilization of Gl biospecimens for C-SiG members to translate signaling research within the paradigm of human specimens. To achieve these aims C-SiG Clinical Core: i) Provides a central access point and streamlined process for biospecimens requests; ii) Strengthens the existing Gl tissue biorepositories by facilitating new specimen collection, and, iii) Develops new tissue collections. The Core integrates existing resources from individual investigators in the Division of Gastroenterology and Hepatology and from institutional biospecimens repositories, providing a cost effective approach to collaboratively translate Gl signaling paradigms into human tissues. Additionally, the C-SiG Clinical Core has developed strong partnerships with the 1R6, anatomic pathology frozen section laboratories (aka TRAG; source of all surgical biospecimens), and the Pathology Research Core (facility that performs tissue sectioning, immunostaining, etc). These partnerships allow C-SiG Clinical Core personnel to expedite movement of protocols and projects through these key institutional resources. The primary services offered by the C-SiG Clinical Core are IR6 protocol development support, biospecimens request support (including identification of appropriate tissues, pathology review, & coordinating tissue processing), and biobank support services (IR6 protocol templates, tissue inventory management software, standardized questionnaires, daily searches of the surgical list for approved 1R6 protocols, and limited study coordinator support for consenting). In response to C-SiG member feedback, we have recently added services to support the collection of stool for human microbiome research. The C-SiG Clinical Core services have been used by 63% of Center members and have supported 49 publications.