Clinical Core

临床核心

• 批准号: 8737728
• 负责人: LISA Allyn BOARDMAN
• 金额: $ 31.63万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8737728
• 关键词: Anatomy; Area; Clinic; Clinical; Collection; Computer software; Consent; Core Facility; Data; Development; Diagnosis; Digestive System Disorders; Disease; Enteral; Equipment and supply inventories; Feces; Feedback; Freezing; Frozen Sections; Funding; Future; Gastroenterology; Gastrointestinal Diseases; Grant; Health Services Accessibility; Hepatology; Human; Human Microbiome; Human Resources; Individual; Inflammation; Inflammatory Bowel Diseases; Institutional Review Boards; Laboratories; Lead; Liver; Monitor; Movement; Neurosciences; Online Systems; Operative Surgical Procedures; Pathology; Patients; Prevention; Process; Protocols documentation; Public Health; Publications; Questionnaires; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Scientist; Services; Signal Transduction; Software Tools; Source; Specimen; Surveys; Tissue Banks; Tissues; Translating; Translational Research; Work; autoimmune pancreatitis; base; biobank; cell transformation; cost; cost effective; design; health care service utilization; human disease; human tissue; member; microbiome; organizational structure; polycystic liver disease; practical application; programs; protocol development; repository; response; sample collection; success; tissue processing; user-friendly

The objective of the C-SiG Clinical Core is to provide a user-friendly, one-stop service to access digestive disease-related biospecimens for Center members. Under the direction of Dr. Lisa Boardman, a well-established clinician scientist with IRB and biobanking expertise, the organization and infrastructure of the CSiG Clinical Core provides essential expertise and personnel to advise and interact with C-SiG members in pursuit of two Specific Aims: First, to provide support to enhance existing individual Gl-related biobanks operating within the Clinical Core umbrella and develop future repositories. Second, to centralize, expedite, and facilitate access to Gl-related biobanks and utilization of Gl biospecimens for C-SiG members to translate signaling research within the paradigm of human specimens. To achieve these aims C-SiG Clinical Core: i) Provides a central access point and streamlined process for biospecimens requests; ii) Strengthens the existing Gl tissue biorepositories by facilitating new specimen collection, and, iii) Develops new tissue collections. The Core integrates existing resources from individual investigators in the Division of Gastroenterology and Hepatology and from institutional biospecimens repositories, providing a cost effective approach to collaboratively translate Gl signaling paradigms into human tissues. Additionally, the C-SiG Clinical Core has developed strong partnerships with the 1R6, anatomic pathology frozen section laboratories (aka TRAG; source of all surgical biospecimens), and the Pathology Research Core (facility that performs tissue sectioning, immunostaining, etc). These partnerships allow C-SiG Clinical Core personnel to expedite movement of protocols and projects through these key institutional resources. The primary services offered by the C-SiG Clinical Core are IR6 protocol development support, biospecimens request support (including identification of appropriate tissues, pathology review, & coordinating tissue processing), and biobank support services (IR6 protocol templates, tissue inventory management software, standardized questionnaires, daily searches of the surgical list for approved 1R6 protocols, and limited study coordinator support for consenting). In response to C-SiG member feedback, we have recently added services to support the collection of stool for human microbiome research. The C-SiG Clinical Core services have been used by 63% of Center members and have supported 49 publications.

C-SiG临床核心的目标是提供一个用户友好的一站式服务，以访问消化道 为中心成员提供疾病相关生物标本。在丽莎博德曼博士的指导下， 具有IRB和生物库专业知识的临床科学家，CSiG的组织和基础设施 临床核心提供必要的专业知识和人员，为C-SiG成员提供建议和互动， 追求两个具体目标：第一，提供支持，以加强现有的个人生物相关的生物库 在临床核心保护伞下运营，并开发未来的存储库。第二，集中，加快， 并促进C-SiG成员访问GI相关生物库和利用GI生物样本， 将信号研究转化为人类样本的范例。为了实现这些目标，C-SiG临床 核心：i）为生物标本申请提供一个中央接入点和简化的流程; ii）加强 通过促进新的标本收集来改进现有的GI组织生物储存库，以及，iii）开发新的组织 收藏.核心小组整合了调查司各个调查员的现有资源， 胃肠病学和肝病学以及机构生物标本库，提供具有成本效益的 本发明涉及一种将GI信号传导范例协同翻译到人组织中的方法。此外，C-SiG Clinical Core与解剖病理学冷冻切片1 R6建立了牢固的合作伙伴关系 实验室（又名TRAG;所有手术生物标本的来源）和病理学研究中心（ 进行组织切片、免疫染色等）。这些合作伙伴关系使C-SiG临床核心人员能够 通过这些关键的机构资源加快议定书和项目的进展。的主要服务 C-SiG临床中心提供IR 6方案开发支持、生物样本请求支持 （包括识别适当的组织、病理学检查和协调组织处理），以及 生物库支持服务（IR 6方案模板、组织库存管理软件、标准化 问卷调查、每日搜索手术列表以获得批准的1 R6方案和有限的研究协调员 支持同意）。为了回应C-SiG成员的反馈，我们最近增加了服务， 支持收集粪便用于人类微生物组研究。C-SiG临床核心服务包括 63%的中心成员使用该软件，并支持49种出版物。