Clinical Core

临床核心

• 批准号: 10630261
• 负责人: LISA Allyn BOARDMAN
• 金额: $ 25.1万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10630261
• 关键词: Anatomy; Area; Bile fluid; Biological Specimen Banks; Cell Separation; Clinic; Clinical; Collection; Computer software; Consent; DNA; Data; Development; Digestive System Disorders; Disease; Diverticulitis; Endoscopy; Enteral; Equipment and supply inventories; Feces; Feedback; Freezing; Fresh Tissue; Frozen Sections; Funding; Gastroenterology; Grant; Health Services Accessibility; Hepatology; Human; Human Microbiome; Human Resources; Individual; Inflammation; Infrastructure; Institution; Institutional Review Boards; Laboratories; Liver; Liver diseases; Mesentery; Microfluidics; Movement; Neurosciences; Online Systems; Operative Surgical Procedures; Organoids; Pathology; Patients; Plasma; Primary Cell Cultures; Procedures; Process; Proteomics; Protocols documentation; Publications; Questionnaires; Research; Research Personnel; Research Project Grants; Resources; Scientist; Serum; Services; Signal Transduction; Software Tools; Source; Standardization; Surveys; Technology; Tissue Banks; Tissues; Translating; Translational Research; base; biobank; cell transformation; cost effective; human tissue; member; microbiome research; organizational structure; patient derived xenograft model; programs; protocol development; repository; response; single cell analysis; small bowel Crohn' s disease; success; support tools; tissue processing; transcriptomics; user-friendly

PROJECT SUMMARY: CLINICAL CORE The objective of the C-SiG Clinical Core is to provide a user-friendly, one-stop service to access digestive disease-related biospecimens for Center members. Under the direction of Dr. Lisa Boardman, a well- established clinician scientist with IRB and biobanking expertise, the organization and infrastructure of the C-SiG Clinical Core provides essential expertise and personnel to advise and interact with C-SiG members in pursuit of two Specific Aims: First, to centralize and expedite access to GI biospecimens for C-SiG members. Second, to enhance existing individual GI-related biobanks operating within the Clinical Core umbrella and develop new repositories. To achieve these aims C-SiG Clinical Core: i) Integrates existing tissue collections and annotated data into a collaborative web-based organizational structure that is easily accessible by C-SiG members; ii) Expedites institutional IRB protocol/biospecimens committee approval and coordinates priority access for C-SiG members to expert intramural biospecimens processing services; and iii) Facilitates the initiation of new biobanks that will focus on new diseases or types of biospecimens not currently collected by existing biobanks, including the development of the new C-SiG Biobank, and iv) Develops and implements software tools that support digestive disease-related biobank endeavors. The Core integrates existing resources from individual investigators in the Division of Gastroenterology and Hepatology and from institutional biospecimens repositories, providing a cost-effective approach to collaboratively translate GI signaling paradigms into human tissues. Additionally, the C-SiG Clinical Core has developed strong partnerships with the IRB, anatomic pathology frozen section laboratories (aka TRAG; source of all surgical biospecimens), and the Pathology Research Core (facility that performs tissue sectioning, immunostaining, etc.). These partnerships allow C-SiG Clinical Core personnel to expedite movement of protocols and projects through these key institutional resources. The primary services offered by the C-SiG Clinical Core are IRB protocol development support, biospecimens request support (including identification of appropriate tissues, pathology review, & coordinating tissue processing), and biobank support services (IRB protocol templates, tissue inventory management software, standardized questionnaires, daily searches of the surgical list for potential biospecimens to be acquired from surgical and/or endoscopy procedures for approved IRB protocols, and limited study coordinator support for consenting). In response to C-SiG member feedback, we have recently added services to support the collection of stool for human microbiome research and are developing an organoid-related service line. The C-SiG Clinical Core services have been used by 54% of the current Center members and have supported 96 publications in the past 4.5 years.

项目总结：临床核心 C-SiG临床核心的目标是提供一个用户友好的一站式服务，以访问消化道 为中心成员提供疾病相关生物标本。在丽莎博德曼博士的指导下，一个很好的- 建立临床科学家与IRB和生物库的专业知识，组织和基础设施， C-SiG临床核心提供必要的专业知识和人员，为C-SiG成员提供建议和互动， 追求两个具体目标：第一，集中和加快获得GI生物标本的C-SiG成员。 第二，加强在临床核心保护伞内运作的现有个人GI相关生物库， 开发新的存储库。为了实现这些目标，C-SiG临床核心：i）整合现有的组织收集 和注释的数据到一个协作的基于Web的组织结构，很容易访问的C-SiG ii）加快机构IRB方案/生物标本委员会的批准并协调优先事项 为C-SiG成员提供专业的校内生物标本处理服务;以及iii）促进 启动新的生物库，重点关注目前未收集的新疾病或生物标本类型 现有的生物库，包括新的C-SiG生物库的开发，以及iv）开发和实施 支持消化系统疾病相关生物库工作的软件工具。核心整合现有 来自胃肠病学和肝病学部门的个体研究者以及来自 机构生物标本库，提供协作翻译GI的具有成本效益的方法 将信号模式导入人体组织。此外，C-SiG临床核心已经发展壮大， 与IRB、解剖病理学冷冻切片实验室（又名TRAG;所有外科手术的来源） 生物标本）和病理学研究中心（进行组织切片，免疫染色， 等）。这些合作伙伴关系使C-SiG临床核心人员能够加快方案和项目的移动 通过这些重要的机构资源。C-SiG临床核心提供的主要服务是IRB 方案开发支持，生物样本请求支持（包括适当组织的鉴定， 病理学检查，和协调组织处理），和生物库支持服务（IRB协议模板， 组织库存管理软件，标准化问卷，每天搜索手术清单， 从经批准的IRB方案的外科手术和/或内窥镜检查程序中获取的潜在生物标本， 和有限的研究协调员对同意的支持）。为了回应C-SiG成员的反馈，我们 最近增加了支持收集粪便用于人类微生物组研究的服务， 类器官相关的服务热线C-SiG临床核心服务已被54%的现有 在过去的4.5年里，中心成员支持了96份出版物。