Behavioral Modulation of Cortical Responses During Complex Sound Perception

复杂声音感知过程中皮质反应的行为调节

• 批准号: 8688413
• 负责人: Michael Scott Osmanski
• 金额: $ 16.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8688413
• 关键词: Acoustics; Address; Animals; Area; Auditory; Auditory Perception; Auditory area; Behavior; Behavioral; Brain; Callithrix; Cells; Cerebral cortex; Cognitive; Complex; Coupling; Cues; Discrimination; Environment; Frequencies; Grant; Hearing; Human; Individual; Investigation; Knowledge; Laboratories; Lateral; Link; Measures; Methods; Modeling; Monkeys; Movement; Neurons; Neurosciences; Noise; Pattern; Perception; Performance; Phylogenetic Analysis; Physiological; Pitch Perception; Population; Primates; Probability; Process; Property; Psychometrics; Psychophysics; Research; Role; Speech Perception; Staging; Stimulus; Structure; Task Performances; Techniques; Work; behavior influence; behavior test; design; interest; neurophysiology; nonhuman primate; novel; perceptual organization; public health relevance; relating to nervous system; research study; response; sound

DESCRIPTION (provided by applicant): A fundamental question in auditory neuroscience is how neural activity in the cerebral cortex gives rise to perception and how changes in brain activity relate to different behavioral states. Activity in primary auditory cortex has been shown to be modulated by engagement in a psychophysical task, but relatively little is known about the causal links between neural activity and perception and how different behavioral states modulate various cortical areas at both the single neuron and population level - especially for non-primary auditory areas. The experiments in this proposal will use a powerful combination of multi-channel neurophysiological techniques and behavioral testing to examine the links between neural activity in auditory cortex and perception at both the individual neuron and population levels in marmosets. Specific Aim 1 examines and compares behavioral modulation of neural responses between two auditory cortical areas. Specific Aim 2 focuses on the correlation between neural responses and marmoset's perception of pitch-bearing harmonic complex tones in the pitch region of auditory cortex. Results of the experiments described here will contribute greatly to our understanding of the perceptual organization of complex sounds and their physiological underpinnings in marmosets. These experiments will also help to elucidate the functional organization of different levels of the auditory cortical hierarchy. Finaly, because of the close phylogenetic relationship between human and nonhuman primates, these results will provide a better understanding of complex sound processing, including speech perception, in human auditory cortex.

描述（由申请人提供）：听觉神经科学的一个基本问题是大脑皮层的神经活动如何引起感知以及大脑活动的变化如何与不同的行为状态相关。初级听觉皮层的活动已被证明是通过参与心理物理任务来调节的，但对于神经活动和感知之间的因果关系以及不同的行为状态如何在单个神经元和群体水平上调节各个皮层区域（尤其是非初级听觉区域）知之甚少。该提案中的实验将使用多通道神经生理学技术和行为测试的强大组合来检查听觉皮层的神经活动与狨猴个体神经元和种群水平的感知之间的联系。具体目标 1 检查并比较两个听觉皮层区域之间神经反应的行为调节。具体目标 2 重点关注神经反应与狨猴对听觉皮层音调区域中的音高谐波复合音调的感知之间的相关性。这里描述的实验结果将极大地有助于我们理解狨猴复杂声音的感知组织及其生理基础。这些实验还将有助于阐明听觉皮层层次结构不同级别的功能组织。最后，由于人类和非人类灵长类动物之间密切的系统发育关系，这些结果将有助于更好地理解人类听觉皮层中复杂的声音处理，包括语音感知。