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Requirement for Sensitive T Cell Response to Antigen

Requirement for Sensitive T Cell Response to Antigen
T 细胞对抗原作出敏感反应的要求
批准号：
8673645
负责人：
Michael Loran Dustin
金额：
$14.0万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-01-28 至 2015-03-31
来源：
https://reporter.nih.gov/project-details/8673645
关键词：
ActinsAdhesionsAgonistAntigen-Presenting CellsAntigensAttentionAutoimmunityCD28 geneCD4 Positive T LymphocytesCD80 geneCell Adhesion MoleculesCell Culture TechniquesChillsComplexCytoplasmic TailDistalEmergency SituationEquilibriumFundingGRP geneHourIL2RA geneImmune responseInstitutesIntercellular adhesion molecule 1LateralLigandsLocationMHC Class II GenesMediator of activation proteinMembraneMicrofilamentsNF-kappa BNonmuscle Myosin Type IIAPalmitic Acylation SitePathway interactionsPeptide/MHC ComplexPeripheralPhysiologicalProcessPublicationsReagentRegulatory T-LymphocyteResolutionRoleSignal PathwaySignal TransductionSiteSon of Sevenless ProteinsStructureT cell responseT-Cell ActivationT-LymphocyteTSG101 geneTranscription Factor AP-1Viral Tumor AntigensWaterWorkcell motilityimmunological synapselatrunculin Amimeticspathogenpolymerizationresearch studyresponsesignal processingsingle molecule

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There were two types of setbacks to this R37 project. Lab staff lost 2 months of work as will be explained and material were destroyed in cold rooms and some refrigerators that failed due to insufficient emergency power early in the outage and loss of the chilled water. The full closure of the Skirball Institute for over 2 weeks caused a disruption of work that resulted in loss of experiments started up on 2 weeks prior to the storm on Oct 29 and required an additional month to fully recover cell cultures and reagents to resume experiments by mid December 2012.
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