Training Program in Immunology and Inflammation

描述（由申请人提供）：纽约大学医学院的免疫学和炎症培训项目将填补基础免疫学和人类疾病之间的博士前和博士后培训的重要空白。纽约大学医学院免疫学和炎症培训项目的目的是为这个快速发展的研究领域提供培训。具体来说，免疫学和炎症项目旨在培训基础免疫学研究领域的学生和博士后研究员，特别是宿主抗微生物保护的机制和途径，当通过遗传或环境扰动以不适当的方式激活时，会导致炎症性疾病。该计划的长期目标是在基础免疫学及其与炎症过程的关系的广泛和跨学科领域培训一批新的研究人员。这些知识可能有助于更好地了解炎症性疾病的原因，并发现和开发新的治疗方法。该培训项目将有 28 名教师，他们都是高产科学家，具有丰富的指导经验（他们在过去十年中总共指导了 282 名学员（103 名博士前和 179 名博士后））。导师们都有一个共同的兴趣，那就是了解基本的免疫机制，以及遗传和环境因素（例如微生物组）对这些机制的扭曲和失调如何导致代谢性疾病、动脉粥样硬化、神经退行性疾病和慢性感染等疾病。我们提出了一个包含 4 个博士前职位和 4 个博士后职位的计划，重点培训免疫学和炎症研究的科学家，这将补充 NYUSoM 现有的 15 个培训计划。免疫学和炎症项目将在高度互动的科学环境中提供智力要求较高的博士前和博士后培训，在鼓励多样性的广泛培训环境中提供严格的课程、教程和研讨会。多层次的指导计划将允许监控研究进展。学员还将获得批判性评估科学数据和文献的能力，并培养他们的写作和演示技能。学生的培训将包括免疫学、遗传学、微生物学、分子肿瘤学、干细胞和寄生虫学方面的严格课程。所有学员都将参加免疫学研讨会系列、年度静修会、期刊俱乐部和讨论小组以及侧重于科学和职业选择中的道德行为的讲座。申请资金支持 4 名博士前培训生和 4 名博士后培训生。这些学员将代表新一代科学家，他们可以为治疗炎症性疾病的新疗法的开发做出贡献。 公共卫生相关性：炎症是一种基本的免疫机制，有助于保护宿主在正常生理条件下免受伤害和感染。过去 15 年进行的研究表明，慢性炎症是许多人类疾病的普遍组成部分，但炎症过程的基本机制以及它们如何导致疾病仍然很大程度上未知。招募和培训新一代最聪明的科学家来研究免疫学和炎症的需要将直接影响我们对许多影响公共卫生的疾病的理解，在这些疾病中炎症会导致免疫系统功能障碍。

DESCRIPTION (provided by applicant): The Immunology and Inflammation training program at NYU School of Medicine will fill an important gap in pre-doctoral and post-doctoral training at the interface between basic immunology and human disease. The intent of the Immunology and Inflammation training program at NYU SoM is to provide training in this rapidly evolving research field. Specifically, the Immunology and Inflammation program aims to train students and postdoctoral fellows in the field of basic immunology research, particularly mechanisms and pathways of host anti-microbial protection that, when activated in an inappropriate manner via either genetic or environmental perturbations, result in inflammatory diseases. A long-term goal of the program is to train a new cadre of researchers in the broad and interdisciplinary area of basic immunology and its relation to inflammatory processes. This knowledge may result in a better understanding of the causes of inflammatory disorders and in the discovery and development of new therapeutic approaches. The training program will have 28 faculty who are highly productive scientists with extensive mentoring experience (they have mentored a total of 282 trainees in the last ten years (103 pre-doctoral and 179 postdoctoral)). The faculty mentors all share a common interest in understanding basic immunological mechanisms and how the distortion and dysregulation of these mechanisms by genetic and environmental factors, such as the microbiome, leads to disease such as metabolic diseases, atherosclerosis, neurodegenerative diseases and chronic infection. We propose a program with 4 pre-doctoral positions and 4 post-doctoral positions focused on training scientists in the study of immunology and inflammation that will complement the 15 existing training programs at NYUSoM. The Immunology and Inflammation program will provide intellectually demanding pre- and postdoctoral training in a highly interactive scientific environment providing rigorous courses, tutorials, and seminars in a broad training environment that encourages diversity. Multi-tiered mentoring plans will allow monitoring of research progress. Trainees will also acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentatin skills. Training of students will include rigorous courses in Immunology, Genetics, Microbiology, Molecular Oncology, Stem Cells and Parasitology. All trainees will participate in the immunology seminar series, an annual retreat, journal clubs and discussion groups as well as lectures focusing on ethical conduct in science and career options. Funds are requested to support 4 pre-doctoral and 4 post-doctoral trainees. These trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat inflammatory diseases. PUBLIC HEALTH RELEVANCE: Inflammation is a basic immunological mechanism that helps to protect the host from injury and infection under normal physiological conditions. Research conducted over the last 15 years has shown that chronic inflammation is a pervasive component in many human diseases, and yet the basic mechanisms underlying inflammatory processes and how they lead to disease remain largely unknown. The need to recruit and train a new generation of the brightest scientists to the study of immunology and inflammation will directly impact on our understanding of numerous diseases of public health import in which inflammation drives dysfunction of the immune system.