Training Program in Immunology and Inflammation

免疫学和炎症培训计划

• 批准号: 8339004
• 负责人: Michael Loran Dustin
• 金额: $ 19.63万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8339004
• 关键词: Immunology; Inflammation; Training Programs

DESCRIPTION (provided by applicant): The Immunology and Inflammation training program at NYU School of Medicine will fill an important gap in pre-doctoral and post-doctoral training at the interface between basic immunology and human disease. The intent of the Immunology and Inflammation training program at NYU SoM is to provide training in this rapidly evolving research field. Specifically, the Immunology and Inflammation program aims to train students and postdoctoral fellows in the field of basic immunology research, particularly mechanisms and pathways of host anti-microbial protection that, when activated in an inappropriate manner via either genetic or environmental perturbations, result in inflammatory diseases. A long-term goal of the program is to train a new cadre of researchers in the broad and interdisciplinary area of basic immunology and its relation to inflammatory processes. This knowledge may result in a better understanding of the causes of inflammatory disorders and in the discovery and development of new therapeutic approaches. The training program will have 28 faculty who are highly productive scientists with extensive mentoring experience (they have mentored a total of 282 trainees in the last ten years (103 pre-doctoral and 179 postdoctoral)). The faculty mentors all share a common interest in understanding basic immunological mechanisms and how the distortion and dysregulation of these mechanisms by genetic and environmental factors, such as the microbiome, leads to disease such as metabolic diseases, atherosclerosis, neurodegenerative diseases and chronic infection. We propose a program with 4 pre-doctoral positions and 4 post-doctoral positions focused on training scientists in the study of immunology and inflammation that will complement the 15 existing training programs at NYUSoM. The Immunology and Inflammation program will provide intellectually demanding pre- and postdoctoral training in a highly interactive scientific environment providing rigorous courses, tutorials, and seminars in a broad training environment that encourages diversity. Multi-tiered mentoring plans will allow monitoring of research progress. Trainees will also acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentatin skills. Training of students will include rigorous courses in Immunology, Genetics, Microbiology, Molecular Oncology, Stem Cells and Parasitology. All trainees will participate in the immunology seminar series, an annual retreat, journal clubs and discussion groups as well as lectures focusing on ethical conduct in science and career options. Funds are requested to support 4 pre-doctoral and 4 post-doctoral trainees. These trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat inflammatory diseases. PUBLIC HEALTH RELEVANCE: Inflammation is a basic immunological mechanism that helps to protect the host from injury and infection under normal physiological conditions. Research conducted over the last 15 years has shown that chronic inflammation is a pervasive component in many human diseases, and yet the basic mechanisms underlying inflammatory processes and how they lead to disease remain largely unknown. The need to recruit and train a new generation of the brightest scientists to the study of immunology and inflammation will directly impact on our understanding of numerous diseases of public health import in which inflammation drives dysfunction of the immune system.

描述（由申请人提供）：纽约大学医学院的免疫学和炎症培训计划将填补基本免疫学和人类疾病之间界面上博物前和博士后培训的重要空白。 NYU SOM的免疫学和炎症培训计划的意图是在这个快速发展的研究领域提供培训。具体而言，免疫学和炎症计划旨在在基本免疫学研究领域培训学生和博士后研究员，尤其是宿主抗微生物保护的机制和途径，当通过遗传或环境扰动以不适当的方式激活时，会导致炎症疾病。该计划的一个长期目标是在基本免疫学的广泛和跨学科领域培训新的研究人员及其与炎症过程的关系。这些知识可能会更好地了解炎症性疾病的原因以及新的治疗方法的发现和发展。该培训计划将有28名教职员工，他们是具有丰富指导经验的高产科学家（在过去的十年中，他们总共指导了282名学员（103名博士后和179个博士后）。教师指导者都在理解基本免疫机制以及通过遗传和环境因素（例如微生物组）对这些机制的失真和失调如何导致疾病，例如代谢性疾病，动脉粥样硬化，神经退行性疾病和慢性感染等疾病。我们提出了一个计划，该计划具有4个博士前职位和4个博后职位，重点是培训科学家在免疫学和炎症研究中，这将补充Nyusom现有的15个现有培训计划。免疫学和炎症计划将在高度互动的科学环境中提供智力苛刻的前和博士后培训，在广泛的培训环境中提供严格的课程，教程和研讨会，以鼓励多样性。多层指导计划将允许监视研究进度。学员还将获得批判性评估科学数据和文献的能力，并将发展他们的写作和表现技巧。对学生的培训将包括严格的免疫学，遗传学，微生物学，分子肿瘤学，干细胞和寄生虫学课程。所有学员将参加免疫学研讨会系列，年度务虚会，期刊俱乐部和讨论小组以及专注于科学和职业选择道德行为的讲座。要求资金支持4名博士后和4名博士后学员。这些学员将代表新一代的科学家，他们可以为治疗炎症性疾病的新疗法做出贡献。 公共卫生相关性：炎症是一种基本的免疫机制，有助于保护宿主在正常生理条件下免受伤害和感染。在过去的15年中进行的研究表明，慢性炎症是许多人类疾病中普遍存在的成分，但是炎症过程的基本机制以及它们如何导致疾病仍然很大程度上是未知的。需要招募和培训新一代最聪明的科学家进行免疫学和炎症研究，这将直接影响我们对多种公共卫生进口疾病的理解，在这种情况下，炎症会导致免疫系统功能障碍。