Maternal acetaminophen use and childhood cancer

母亲使用对乙酰氨基酚与儿童癌症

• 批准号: 10852089
• 负责人: Julia Heck
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF NORTH TEXAS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10852089
• 关键词: Acetaminophen; Address; Administrative Supplement; Age; Amblyopia; Asthma; Autoimmune Diseases; Birth; Caring; Case/Control Studies; Cerebral Palsy; Child; Childhood Leukemia; Chronic Obstructive Pulmonary Disease; Code; Cohort Studies; Colitis; Collaborations; Communities; Complex Analysis; Confounding Factors (Epidemiology); Congenital Heart Defects; Control Groups; Data; Databases; Denmark; Diagnosis; Diagnostic; Down Syndrome; Eczema; Epilepsy; Foundations; Funding; Goals; Grant; Guidelines; Health; Hospitals; Hypertension; ICD-9; Individual; Infantile spasms; Intake; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Investigation; Link; Longevity; Malignant Childhood Neoplasm; Malignant Neoplasms; Managed Care; Maternal Age; Maternal and Child Health; Medical; Medical Records; Mental Health; Musculoskeletal; National Health Insurance; Obstructive Sleep Apnea; Occupational; Parents; Participant; Patient Care Management; Patients; Persons; Pharmacologic Substance; Phenotype; Pneumonia; Population; Population Registers; Pregnancy; Prevalence; Prevalence Study; Registries; Reporting; Research; Research Design; Resources; Risk; Risk Estimate; Sample Size; Sampling; Selection Bias; Taiwan; Thyroid Gland; abortion; autism spectrum disorder; cancer diagnosis; cohort; community setting; comorbidity; early childhood; health care service utilization; hypercholesterolemia; improved; leukemia; neoplasm registry; population based; prenatal; prospective; respiratory; screening; screening guidelines; young adult

Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.

项目概要/摘要 该提案是对 NOT-OD-22-137 的回应：包括的行政补充的可用性 （调查整个生命周期中同时发生的情况以了解唐氏综合症）项目。我们的目标 解决第 2 部分：“聚集一大批一生中患有唐氏综合症的个体， 进行深度表型分析并研究共存条件。”我们将以 230 万人的大规模研究为基础 台湾出生，我们正在调查母亲怀孕期间的药物摄入量及其关联 患有儿童癌症；家长研究的目标不会改变。在美国，唐氏综合症的人口患病率 美国有 25 万人患有 DS 综合症，每年有 6000 名患有 DS 的儿童出生。患有唐氏病的儿童 综合症会显着增加患白血病的风险，并增加患许多其他疾病的风险。 拟议的研究将利用大量台湾儿童的数据来检查共病状况 患有唐氏综合症的儿童。我们研究的参与者包括 2004 年至 2015 年在台湾出生的所有儿童。向下 综合症和其他诊断将通过台湾国民健康保险数据库确定。 结果将在一大群丹麦儿童中得到证实。该项目的目标是更好地了解 唐氏综合症的合并症，以改善筛查指南和患者护理管理。