Maternal acetaminophen use and childhood cancer

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Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.