Maternal acetaminophen use and childhood cancer
母亲使用对乙酰氨基酚与儿童癌症
基本信息
- 批准号:10852089
- 负责人:
- 金额:$ 3.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcetaminophenAddressAdministrative SupplementAgeAmblyopiaAsthmaAutoimmune DiseasesBirthCaringCase/Control StudiesCerebral PalsyChildChildhood LeukemiaChronic Obstructive Pulmonary DiseaseCodeCohort StudiesColitisCollaborationsCommunitiesComplex AnalysisConfounding Factors (Epidemiology)Congenital Heart DefectsControl GroupsDataDatabasesDenmarkDiagnosisDiagnosticDown SyndromeEczemaEpilepsyFoundationsFundingGoalsGrantGuidelinesHealthHospitalsHypertensionICD-9IndividualInfantile spasmsIntakeInternational Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)InvestigationLinkLongevityMalignant Childhood NeoplasmMalignant NeoplasmsManaged CareMaternal AgeMaternal and Child HealthMedicalMedical RecordsMental HealthMusculoskeletalNational Health InsuranceObstructive Sleep ApneaOccupationalParentsParticipantPatient Care ManagementPatientsPersonsPharmacologic SubstancePhenotypePneumoniaPopulationPopulation RegistersPregnancyPrevalencePrevalence StudyRegistriesReportingResearchResearch DesignResourcesRiskRisk EstimateSample SizeSamplingSelection BiasTaiwanThyroid Glandabortionautism spectrum disordercancer diagnosiscohortcommunity settingcomorbidityearly childhoodhealth care service utilizationhypercholesterolemiaimprovedleukemianeoplasm registrypopulation basedprenatalprospectiverespiratoryscreeningscreening guidelinesyoung adult
项目摘要
Project Summary/Abstract
This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE
(INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim
to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to
perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million
Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations
with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down
syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down
syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions.
The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions
in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down
syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan.
Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand
comorbidities in Down syndrome to improve screening guidelines and management of patient care.
项目总结/摘要
本提案响应了NOT-OD-22-137:INCLUDE管理补充材料的可用性
(调查整个生命周期的共现条件,以了解唐氏综合征)项目。我们的目标
解决组件2:“在整个生命周期内组装一大批唐氏综合征患者,
进行深入的表型分析和研究共存的条件。”我们将在230万美元的大型研究基础上,
台湾出生,其中我们正在调查母亲在怀孕期间的药物摄入量和协会
儿童癌症;父母研究的目的不会改变。在美国,唐氏症的人口患病率
综合征(DS)是250,000人,每年有6000名DS儿童在美国出生。儿童Down
综合征具有显著增加的白血病风险,以及增加的许多其它病症的风险。
这项研究将利用来自台湾儿童的大量数据来检查共病情况
唐氏综合症患儿的情况我们的研究对象包括2004-2015年在台湾出生的所有儿童。下来
综合征和其他诊断将从台湾的国家健康保险数据库中确定。
结果将在一个大型丹麦儿童队列中得到证实。这个项目的目标是更好地理解
唐氏综合征合并症,以改善筛查指南和病人护理管理。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Julia Heck其他文献
Julia Heck的其他文献
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{{ truncateString('Julia Heck', 18)}}的其他基金
Maternal acetaminophen use and childhood cancer
母亲使用对乙酰氨基酚与儿童癌症
- 批准号:
10675108 - 财政年份:2022
- 资助金额:
$ 3.1万 - 项目类别:
Maternal acetaminophen use and childhood cancer
母亲使用对乙酰氨基酚与儿童癌症
- 批准号:
10512922 - 财政年份:2022
- 资助金额:
$ 3.1万 - 项目类别:
Metabolomic profiling of retinoblastoma (MPR)
视网膜母细胞瘤的代谢组学分析 (MPR)
- 批准号:
10046917 - 财政年份:2020
- 资助金额:
$ 3.1万 - 项目类别:
Childhood Cancer and Industrial Pollution (CHIP)
儿童癌症与工业污染 (CHIP)
- 批准号:
10046486 - 财政年份:2020
- 资助金额:
$ 3.1万 - 项目类别:
Maternal comorbidities, prescription drug use in pregnancy and childhood cancer
孕产妇合并症、妊娠期处方药使用和儿童癌症
- 批准号:
8838060 - 财政年份:2014
- 资助金额:
$ 3.1万 - 项目类别:
Maternal comorbidities, prescription drug use in pregnancy and childhood cancer
孕产妇合并症、妊娠期处方药使用和儿童癌症
- 批准号:
8691193 - 财政年份:2014
- 资助金额:
$ 3.1万 - 项目类别:
Air Pollution and Childhood Cancers in California
加利福尼亚州的空气污染和儿童癌症
- 批准号:
7875378 - 财政年份:2010
- 资助金额:
$ 3.1万 - 项目类别:
Air Pollution and Childhood Cancers in California
加利福尼亚州的空气污染和儿童癌症
- 批准号:
8053356 - 财政年份:2010
- 资助金额:
$ 3.1万 - 项目类别:
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