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Maternal acetaminophen use and childhood cancer

母亲使用对乙酰氨基酚与儿童癌症

基本信息

批准号：
10852089
负责人：
Julia Heck
金额：
$ 3.1万
依托单位：
UNIVERSITY OF NORTH TEXAS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10852089
关键词：
Acetaminophen Address Administrative Supplement Age Amblyopia Asthma Autoimmune Diseases Birth Caring Case/Control Studies Cerebral Palsy Child Childhood Leukemia Chronic Obstructive Pulmonary Disease Code Cohort Studies Colitis Collaborations Communities Complex Analysis Confounding Factors (Epidemiology)Congenital Heart Defects Control Groups Data Databases Denmark Diagnosis Diagnostic Down Syndrome Eczema Epilepsy Foundations Funding Goals Grant Guidelines Health Hospitals Hypertension ICD-9 Individual Infantile spasms Intake International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)Investigation Link Longevity Malignant Childhood Neoplasm Malignant Neoplasms Managed Care Maternal Age Maternal and Child Health Medical Medical Records Mental Health Musculoskeletal National Health Insurance Obstructive Sleep Apnea Occupational Parents Participant Patient Care Management Patients Persons Pharmacologic Substance Phenotype Pneumonia Population Population Registers Pregnancy Prevalence Prevalence Study Registries Reporting Research Research Design Resources Risk Risk Estimate Sample Size Sampling Selection Bias Taiwan Thyroid Gland abortion autism spectrum disorder cancer diagnosis cohort community setting comorbidity early childhood health care service utilization hypercholesterolemia improved leukemia neoplasm registry population based prenatal prospective respiratory screening screening guidelines young adult

项目摘要

Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.

项目总结/文摘