Maternal acetaminophen use and childhood cancer

母亲使用对乙酰氨基酚与儿童癌症

• 批准号: 10852089
• 负责人: Julia Heck
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF NORTH TEXAS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10852089
• 关键词: Acetaminophen; Address; Administrative Supplement; Age; Amblyopia; Asthma; Autoimmune Diseases; Birth; Caring; Case/Control Studies; Cerebral Palsy; Child; Childhood Leukemia; Chronic Obstructive Pulmonary Disease; Code; Cohort Studies; Colitis; Collaborations; Communities; Complex Analysis; Confounding Factors (Epidemiology); Congenital Heart Defects; Control Groups; Data; Databases; Denmark; Diagnosis; Diagnostic; Down Syndrome; Eczema; Epilepsy; Foundations; Funding; Goals; Grant; Guidelines; Health; Hospitals; Hypertension; ICD-9; Individual; Infantile spasms; Intake; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Investigation; Link; Longevity; Malignant Childhood Neoplasm; Malignant Neoplasms; Managed Care; Maternal Age; Maternal and Child Health; Medical; Medical Records; Mental Health; Musculoskeletal; National Health Insurance; Obstructive Sleep Apnea; Occupational; Parents; Participant; Patient Care Management; Patients; Persons; Pharmacologic Substance; Phenotype; Pneumonia; Population; Population Registers; Pregnancy; Prevalence; Prevalence Study; Registries; Reporting; Research; Research Design; Resources; Risk; Risk Estimate; Sample Size; Sampling; Selection Bias; Taiwan; Thyroid Gland; abortion; autism spectrum disorder; cancer diagnosis; cohort; community setting; comorbidity; early childhood; health care service utilization; hypercholesterolemia; improved; leukemia; neoplasm registry; population based; prenatal; prospective; respiratory; screening; screening guidelines; young adult

Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.

项目总结/摘要 本提案响应了NOT-OD-22-137：INCLUDE管理补充材料的可用性 （调查整个生命周期的共现条件，以了解唐氏综合征）项目。我们的目标 解决组件2：“在整个生命周期内组装一大批唐氏综合征患者， 进行深入的表型分析和研究共存的条件。”我们将在230万美元的大型研究基础上， 台湾出生，其中我们正在调查母亲在怀孕期间的药物摄入量和协会 患有儿童癌症;父母研究的目标不会改变。在美国，唐氏症的人口患病率 综合征（DS）是250，000人，每年有6000名DS儿童在美国出生。儿童Down 综合征具有显著增加的白血病风险，以及增加的许多其它病症的风险。 这项研究将利用来自台湾儿童的大量数据来检查共病情况 唐氏综合症患儿的情况我们的研究对象包括2004-2015年在台湾出生的所有儿童。下来 综合征和其他诊断将从台湾的国家健康保险数据库中确定。 结果将在一个大型丹麦儿童队列中得到证实。该项目的目标是更好地了解 唐氏综合征合并症，以改善筛查指南和病人护理管理。