Children of Bipolar Parents: A High-Risk Follow-up Study

双相情感障碍父母的孩子:一项高风险随访研究

基本信息

  • 批准号:
    8670767
  • 负责人:
  • 金额:
    $ 119.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-08-20 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This is a renewal of the protocol entitled "Children of Bipolar Parents: A High-Risk Follow-up Study" (NIMH #60952) also known as the Bipolar Offspring Study (BIOS). In line with the current NIMH Strategic Plan, BIOS has been investigating the additive effects of behavioral, affective, circadian/sleep, genetic, and psychosocial factors associated with the development of mood disorders in the offspring of parents with bipolar disorder (BP). Enrollment of BIOS sample was completed in July 2007 with 862 children recruited (509 from parents with BP and 353 from community control parents) and a retention rate of 87%. Interviewers, blind to parental diagnosis, assessed offspring every other year with a comprehensive battery of instruments. BIOS is beginning to elucidate a specific developmental progression to bipolarity in the offspring of parents with BP and as to date, offspring of parents with BP are at significantly higher risk to develop BP-I (OR: 19.5) or subsyndromal BP (OR: 31.2). Since most of the sample will enter the age of highest risk to develop BP and other mood disorders during the next funding period, we are proposing to continue to study this sample for 5 more years. For a subset of 200 children of parents with BP and control parents, we propose to measure neurocognitive functioning and activity in, and functional and anatomic connectivity between, neural regions implicated in the pathogenesis of BP, and obtain more precise measurements of puberty using salivary hormonal levels. We hypothesize that, relative to offspring of control parents, offspring of parents with BP will develop over follow-up: 1) higher rates of mood disorders and psychopathology (e.g., mood lability, disrupted sleep) and 2) deficits in neurocognitive functioning and neurocircuitry associated with emotion processing and regulation. In addition, in offspring of parents with BP, onset of BP or any mood disorder will be predicted by the combined effects of development, demographic factors, other psychiatric disorders, dimensional behavioral and mood phenotypes, family environmental factors, and their interactions. Within the subset of offspring of parents with BP who will have neurocognitive and neuroimaging data, onset of BP or any mood disorder will be predicted by abnormal neurocognitive functioning and activity and connectivity in neural circuitry for emotion processing and regulation, that in turn will be associated with sleep and circadian factors, puberty, and clinical and demographic risk factors identified above. Findings from this large study will help identify the initial symptoms and neurobiomarkers related to increased risk of BP in youth. Such findings will facilitate prompt diagnosis and interventions, thus preventing, or at least ameliorating, the negative effects of this severe illness in youth.
描述(由申请方提供):这是对标题为“双相父母的儿童:高风险随访研究”(NIMH#60952)(也称为双相后代研究(BIOS))的方案的更新。根据目前的NIMH战略计划,BIOS一直在研究与双相情感障碍(BP)父母的后代发生心境障碍相关的行为、情感、昼夜节律/睡眠、遗传和心理社会因素的叠加效应。BIOS样本的招募于2007年7月完成,招募了862名儿童(509名来自BP父母,353名来自社区对照父母),留存率为87%。采访者对父母的诊断一无所知,每隔一年用一套全面的仪器对后代进行评估。BIOS开始阐明父母患有BP的后代向双极性的特定发育进展,迄今为止,父母患有BP的后代患BP-I(OR:19.5)或亚综合征BP(OR:31.2)的风险显著更高。由于大多数样本将在下一个资助期内进入患BP和其他情绪障碍的最高风险年龄,我们建议继续研究该样本5年。对于一个子集的200名儿童的父母与BP和控制的父母,我们建议测量神经认知功能和活动,功能和解剖之间的连接,神经区域牵连的发病机制BP,并获得更精确的测量青春期唾液激素水平。我们假设,相对于对照父母的后代,患有BP的父母的后代将在随访中发展:1)更高的情绪障碍和精神病理学(例如,情绪不稳定、睡眠中断)和2)与情绪处理和调节相关的神经认知功能和神经回路缺陷。此外,在患有BP的父母的后代中,BP或任何情绪障碍的发作将通过发育、人口统计学因素、其他精神障碍、维度行为和情绪表型、家庭环境因素及其相互作用的综合影响来预测。在具有神经认知和神经成像数据的患有BP的父母的后代的子集内,BP或任何情绪障碍的发作将通过异常的神经认知功能以及用于情绪处理和调节的神经回路中的活动和连接来预测,这反过来将与睡眠和昼夜因素、青春期以及上述确定的临床和人口统计学风险因素相关。这项大型研究的结果将有助于确定与青年BP风险增加相关的初始症状和神经生物标志物。这些发现将有助于及时诊断和干预,从而预防或至少减轻这种严重疾病对青年的负面影响。

项目成果

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BORIS BIRMAHER其他文献

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{{ truncateString('BORIS BIRMAHER', 18)}}的其他基金

Course and Outcome of Bipolar Disorder in Youth - Supplement
青少年双相情感障碍的病程和结果 - 补充
  • 批准号:
    10397801
  • 财政年份:
    2021
  • 资助金额:
    $ 119.97万
  • 项目类别:
Predicting Recurrences in Bipolar Illness (Prompt-BD)
预测双相情感障碍的复发 (Prompt-BD)
  • 批准号:
    10275582
  • 财政年份:
    2021
  • 资助金额:
    $ 119.97万
  • 项目类别:
Predicting Recurrences in Bipolar Illness (Prompt-BD)
预测双相情感障碍的复发 (Prompt-BD)
  • 批准号:
    10474530
  • 财政年份:
    2021
  • 资助金额:
    $ 119.97万
  • 项目类别:
Predicting Recurrences in Bipolar Illness (Prompt-BD)
预测双相情感障碍的复发 (Prompt-BD)
  • 批准号:
    10656413
  • 财政年份:
    2021
  • 资助金额:
    $ 119.97万
  • 项目类别:
1/2 Predicting Adult Outcomes in Bipolar Youth (PROBY)
1/2 预测双相情感障碍青少年的成年结局 (PROBY)
  • 批准号:
    10326340
  • 财政年份:
    2018
  • 资助金额:
    $ 119.97万
  • 项目类别:
1/2 Predicting Adult Outcomes in Bipolar Youth (PROBY)
1/2 预测双相情感障碍青少年的成年结局 (PROBY)
  • 批准号:
    10088476
  • 财政年份:
    2018
  • 资助金额:
    $ 119.97万
  • 项目类别:
Longitudinal Assessment of Manic Symptoms
躁狂症状的纵向评估
  • 批准号:
    8268504
  • 财政年份:
    2005
  • 资助金额:
    $ 119.97万
  • 项目类别:
Longitudinal Assessment of Manic Symptoms
躁狂症状的纵向评估
  • 批准号:
    8485163
  • 财政年份:
    2005
  • 资助金额:
    $ 119.97万
  • 项目类别:
Longitudinal Assessment of Manic Symptoms
躁狂症状的纵向评估
  • 批准号:
    8100164
  • 财政年份:
    2005
  • 资助金额:
    $ 119.97万
  • 项目类别:
Longitudinal Assessment of Manic Symptoms
躁狂症状的纵向评估
  • 批准号:
    8441603
  • 财政年份:
    2005
  • 资助金额:
    $ 119.97万
  • 项目类别:

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