Center of Biomedical Research

生物医学研究中心

• 批准号: 8625918
• 负责人: JULIA THOM OXFORD
• 金额: $ 199.65万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8625918
• 关键词: Address; Animal Model; Biology; Biomedical Research; Cardiovascular system; Cells; Centers of Research Excellence; Collaborations; Disease Progression; Environment; Extracellular Matrix; Functional disorder; Funding; Goals; Health; Individual; Interdisciplinary Study; Laboratories; Liver Fibrosis; Molecular; Names; Natural regeneration; Neoplasm Metastasis; Pilot Projects; Prevention; Productivity; Reagent; Research; Research Infrastructure; Research Personnel; Research Support; Scientist; Tissues; Universities; Vision; base; calcification; career development; disease diagnosis; instrumentation; ligament injury; member; novel strategies; programs; public health relevance; skills; tissue repair

DESCRIPTION (provided by applicant): Boise State University has an emerging record of excellence in matrix biology research and application to many of the most challenging health concerns facing our nation. Historically, the base for the research effort has been from individual laboratories in distinct departments. In recent years, ad hoc collaborations have developed between independent researchers, in an interdisciplinary manner, significantly expanding the research skill set and vision applied to health. To date, we have been limited by the lack of a centralized mechanism to leverage new collaborations efficiently into new research discoveries. To capitalize on the broad, diverse research base, we propose to create the Center of Biomedical Research Excellence (COBRE) in Matrix Biology. Boise State's biomedical research base has over 50 members who have generated over $155M in research support in the past decade. The primary goals of the COBRE in Matrix Biology are 1) to support junior investigators, 2) to enhance the productivity of established scientists, 3) to facilitate collaboration between both junior and established researchers, and 4) to build biomedical research infrastructure. Programmatic emphases are to support the analysis of animal models relevant to cell-matrix interactions in disease progression and tissue repair/regeneration and to provide access to instrumentation and technical support. Three Cores are proposed: an Administrative Core, a Biomedical Research Vivarium Core, and a Biomolecular Research Core. Our research efforts will be directed toward an understanding of extracellular matrix at the molecular, cellular, and tissue levels to directly impact our understanding of the pathophysiology of cancer metastasis, cardiovascular calcification, liver fibrosis, and ligament injury to name a few. The Administrative Core will sponsor career development of junior investigators, facilitate new collaborations between established investigators, sponsor activities to promote exchange of information, ideas and reagents, and engage non-members doing meritorious research within the thematic focus of matrix biology. A Pilot Project program will provide funding to young investigators and to established investigators who propose applying their expertise to matrix biology.

描述（由申请人提供）：博伊西州立大学在基质生物学研究和应用于我们国家面临的许多最具挑战性的健康问题方面有着卓越的记录。从历史上看，研究工作的基础是从个人