Center of Biomedical Research Excellence in Matrix Biology Phase II

基质生物学卓越生物医学研究中心第二期

• 批准号: 10226307
• 负责人: JULIA THOM OXFORD
• 金额: $ 210.75万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226307
• 关键词: Address; Area; Award; Bioinformatics; Biology; Biomedical Engineering; Biomedical Research; Biometry; Centers of Research Excellence; Chemistry; Collaborations; Communities; Core Facility; Development; Development Plans; Discipline; Disease; Disease Progression; Electrical Engineering; Engineering; Environment; Extracellular Matrix; Extramural Activities; Face; Funding; Future; Goals; Grant; Growth; Health; Histology; Idaho; Individual; Infrastructure; Institution; Interdisciplinary Study; Investigation; Journals; Laboratories; Manuscripts; Mechanics; Mentors; Natural regeneration; Nature; Peer Review; Phase; Physics; Pilot Projects; Positioning Attribute; Prevention; Principal Investigator; Proteomics; Publishing; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Role; Science; Secure; Tissues; Universities; career development; computer science; disease diagnosis; improved; instrumentation; laboratory facility; materials science; metabolomics; microscopic imaging; multidisciplinary; programs; recruit; repaired; success; therapeutic development; training opportunity

Project Summary/Abstract - Overall The long-term goal of the Center of Biomedical Research Excellence (COBRE) in Matrix Biology is to establish, enhance, and actively advance a multidisciplinary research center focusing on improving our understanding of the role of the extracellular matrix in development, health, and disease, and contributing to the prevention, treatment, and cure for diseases of high priority. Since the beginning of Phase I in 2014, we have vigorously intervened limitations that hinder achieving our goals. Program accomplishments resulting from career development and mentoring of junior investigators led to an increase in research grant awards during Phase I. We accomplished an increase in access to and use of shared instrumentation within the COBRE Core facilities. Most importantly, a culture shift has occurred at Boise State University. Seven investigators received significant new funding and graduated from the COBRE mentoring program. The Pilot Project Program contributed to investigator success and served as an onramp for two of our Research Project Investigators working toward R01 grant submission during Phase II. A critical mass of investigators has been established around the thematic focus of matrix biology that includes a diverse cadre from disciplines including biology, chemistry, physics, materials science, computer science, mechanical and biomedical engineering, and electrical engineering. The COBRE program has put Boise State in a position to make significant contributions to solutions addressing national health concerns. New laboratories have been built and core facilities have been established supporting proteomics and metabolomics, histology, microscopy, imaging, and biostatistics/bioinformatics. COBRE investigators published 98 peer-reviewed manuscripts including noteworthy articles in journals of high impact. Phase II is critically important for us to continue our upward momentum toward our goals of research growth over the next five years. To achieve this overarching goal, four specific aims are proposed: 1) enhance and grow upon the critical mass of investigators established around the thematic multidisciplinary focus of matrix biology, 2) enhance biomedical research core capabilities, 3) grow research collaborations with existing programs, and 4) enhance research training opportunities. Upon successful completion of the proposed aims, we will have strengthened and enhanced the critical mass of investigators with shared priorities in understanding the role of the matrix in development and disease. Shared core facilities will be enhanced and will support the needs of more investigators as they follow a mentored career development plan. The multidisciplinary nature that was established in Phase I will continue to grow to include additional investigators across our institution.

项目概要/摘要-总体 矩阵生物学卓越生物医学研究中心（COBRE）的长期目标是 建立，加强和积极推进多学科研究中心，重点是提高我们的 了解细胞外基质在发育，健康和疾病中的作用，并有助于 预防、治疗和治愈高度优先的疾病。自2014年第一阶段开始以来，我们 积极干预阻碍我们实现目标的限制。方案成果 从职业发展和指导初级研究人员导致增加了研究补助金 在第一阶段。我们实现了对共享工具的访问和使用的增加， 核心设施。最重要的是，博伊西州立大学发生了文化转变。七 调查人员获得了大量新的资金，并从COBRE指导计划中毕业。试点 项目计划有助于研究者的成功，并作为我们两个研究项目的入口 研究人员在第二阶段期间致力于R 01资助提交。大量的调查人员 围绕基质生物学的主题重点建立，包括来自学科的多样化干部， 生物、化学、物理、材料科学、计算机科学、机械和生物医学工程，以及 电气工程COBRE计划使博伊西州立大学能够做出重大贡献 解决国家健康问题的方法。新的实验室已经建成，核心设施已经 已建立支持蛋白质组学和代谢组学，组织学，显微镜，成像， 生物统计学/生物信息学。COBRE研究人员发表了98篇同行评议的手稿， 在具有高影响力的期刊上发表值得注意的文章。第二阶段对我们继续保持增长至关重要 在未来五年内，我们将朝着研究增长的目标前进。为了实现这一总体目标，四 提出了具体目标：1）加强和发展周围建立的调查人员的临界质量， 矩阵生物学的主题多学科重点，2）提高生物医学研究的核心能力，3） 增加与现有项目的研究合作，以及4）增加研究培训机会。后 成功完成拟议目标，我们将加强和提高 研究人员在理解矩阵在发展和疾病中的作用方面具有共同的优先事项。共享 核心设施将得到加强，并将支持更多调查人员的需要，因为他们遵循一个指导， 职业发展计划。在第一阶段建立的多学科性质将继续发展， 包括我们机构其他调查人员。