Center of Biomedical Research Excellence in Matrix Biology Phase II

项目概要/摘要 矩阵生物学卓越生物医学研究中心（COBRE）的长期目标是 建立，加强和积极推进多学科研究中心，重点是提高我们的 了解细胞外基质在发育，健康和疾病中的作用，并有助于 预防、治疗和治愈高度优先的疾病。我们建议增加获取和使用 通过购买蔡司Axio Observer 7 Live，在COBRE核心设施内共享仪器 细胞成像系统。这种新的活细胞成像系统将支持研究人员， 围绕着矩阵生物学的主题。矩阵生物学中的COBRE内的调查人员是多样化的， 尊重他们所代表的主要学科，包括生物学，化学，物理学，材料科学， 计算机科学、机械和生物医学工程以及电气工程。坚强体制 提供了新改建的实验室空间和人员，通过培训支持使用， 维护和帮助新用户。活细胞成像系统将位于新实验室内 共享核心设施的空间，以支持整个校园的调查人员。加强后的核心设施将 使研究人员能够进行更复杂的实验，以解决细胞如何对它们的反应。 环境通过细胞外基质。结果将通过同行审议出版物在 科学期刊和国家研究会议上的演讲。新仪器的购置 将有助于实现我们的总体目标，即：1）加强和发展关键的 围绕基质生物学的主题多学科焦点建立的大量研究人员，2）增强 生物医学研究的核心能力，3）与现有项目的研究合作增长，以及4）增强 研究培训机会。在成功完成建议的目标后，我们将加强 并加强了调查员的必要数量，他们在了解信息总库在以下方面的作用方面有着共同的优先事项： 发展和疾病。共享的核心设施将得到加强，并将支持更多人的需求。 调查人员遵循一个有指导的职业发展计划。多学科团队的科学性 将继续增长，包括我们机构的其他研究人员。

Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) in Matrix Biology is to establish, enhance, and actively advance a multidisciplinary research center focusing on improving our understanding of the role of the extracellular matrix in development, health, and disease, and contributing to the prevention, treatment, and cure for diseases of high priority. We propose to increase access to and use of shared instrumentation within the COBRE Core facilities through the purchase of a Zeiss Axio Observer 7 Live Cell Imaging system. This new live cell imaging system will support the investigators that have coalesced around the thematic focus of matrix biology. Investigators within the COBRE in Matrix Biology are diverse with respect to the primary disciplines that they represent, including biology, chemistry, physics, materials science, computer science, mechanical and biomedical engineering, and electrical engineering. Strong institutional support provided newly remodeled laboratory space and personnel to support the use through training, maintenance, and assistance for new users. The live cell imaging system will be located within new laboratory space for shared core facilities to support investigators from across campus. The enhanced core facilities will allow investigators to carry out more sophisticated experiments that address how cells respond to their environment through their extracellular matrix. Results will be disseminated through peer review publication in scientific journals and presentations at national research conferences. The acquisition of the new instrument will facilitate the achievement of our overarching goals which are to: 1) enhance and grow upon the critical mass of investigators established around the thematic multidisciplinary focus of matrix biology, 2) enhance biomedical research core capabilities, 3) grow research collaborations with existing programs, and 4) enhance research training opportunities. Upon successful completion of the proposed aims, we will have strengthened and enhanced the critical mass of investigators with shared priorities in understanding the role of the matrix in development and disease. Shared core facilities will be enhanced and will support the needs of more investigators as they follow a mentored career development plan. The multidisciplinary team science nature will continue to grow to include additional investigators across our institution.