Center of Biomedical Research Excellence in Matrix Biology Phase II

项目摘要/摘要 基质生物学生物医学研究卓越中心(COBRE)的长期目标是 建立、加强和积极推进多学科研究中心，专注于改善我们的 了解细胞外基质在发育、健康和疾病中的作用，并有助于 预防、治疗和治愈高度优先的疾病。我们建议增加获取和使用 通过购买Zeiss Axio观察者7 Live，在Cobre核心设施内共享仪器 细胞成像系统。这一新的活细胞成像系统将支持已经联合起来的研究人员 围绕基质生物学这一主题展开讨论。在基质生物学的科布雷内部的研究人员多种多样 尊重他们所代表的主要学科，包括生物、化学、物理、材料科学、 计算机科学、机械和生物医学工程以及电气工程。强大的机构 支持提供新改建的实验室空间和人员，以通过培训支持使用， 为新用户提供维护和帮助。活细胞成像系统将设在新实验室内 共享核心设施的空间，以支持来自整个校园的调查人员。经加强的核心设施将 允许研究人员进行更复杂的实验，以解决细胞如何对其进行反应 通过它们的细胞外基质来保护环境。结果将通过同行评议出版物在 科学期刊和在国家研究会议上的演讲。新仪器的收购 将有助于实现我们的总体目标，即：1)加强和发展关键 围绕基质生物学的主题多学科焦点建立的大量研究人员，2)加强 生物医学研究核心能力，3)加强与现有计划的研究合作，4)增强 研究培训机会。在成功完成拟议的目标后，我们将加强 并加强了具有共同优先事项的调查人员的临界质量，以了解矩阵在 发展和疾病。共享的核心设施将得到增强，并将支持更多 调查人员遵循有指导的职业发展计划。多学科团队的科学性 将继续增长，包括我们机构的更多调查人员。

Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) in Matrix Biology is to establish, enhance, and actively advance a multidisciplinary research center focusing on improving our understanding of the role of the extracellular matrix in development, health, and disease, and contributing to the prevention, treatment, and cure for diseases of high priority. We propose to increase access to and use of shared instrumentation within the COBRE Core facilities through the purchase of a Zeiss Axio Observer 7 Live Cell Imaging system. This new live cell imaging system will support the investigators that have coalesced around the thematic focus of matrix biology. Investigators within the COBRE in Matrix Biology are diverse with respect to the primary disciplines that they represent, including biology, chemistry, physics, materials science, computer science, mechanical and biomedical engineering, and electrical engineering. Strong institutional support provided newly remodeled laboratory space and personnel to support the use through training, maintenance, and assistance for new users. The live cell imaging system will be located within new laboratory space for shared core facilities to support investigators from across campus. The enhanced core facilities will allow investigators to carry out more sophisticated experiments that address how cells respond to their environment through their extracellular matrix. Results will be disseminated through peer review publication in scientific journals and presentations at national research conferences. The acquisition of the new instrument will facilitate the achievement of our overarching goals which are to: 1) enhance and grow upon the critical mass of investigators established around the thematic multidisciplinary focus of matrix biology, 2) enhance biomedical research core capabilities, 3) grow research collaborations with existing programs, and 4) enhance research training opportunities. Upon successful completion of the proposed aims, we will have strengthened and enhanced the critical mass of investigators with shared priorities in understanding the role of the matrix in development and disease. Shared core facilities will be enhanced and will support the needs of more investigators as they follow a mentored career development plan. The multidisciplinary team science nature will continue to grow to include additional investigators across our institution.