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Infant Brain and Behavioral Signatures of Later Emerging Risk for Psychopathology

婴儿大脑和后来出现的精神病理学风险的行为特征

基本信息

批准号：
8755214
负责人：
Jed Thomas Elison
金额：
$ 46.26万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-29 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8755214
关键词：
Acceleration Adaptive Behaviors Age Age-Months Anxiety Disorders Arousal Attention deficit hyperactivity disorder Autacoids Autistic Disorder Behavior Behavior assessment Behavioral Biological Psychiatry Brain Brain imaging Brain region Child Child Behavior Checklist Clinical Cognitive Complement Coupled Data Development Developmental Process Diagnostic and Statistical Manual of Mental Disorders Disease Early Intervention Early identification Emotional Event Eye Foundations Functional Magnetic Resonance Imaging Functional disorder Future Goals Head Human Individual Differences Infant Interview Life Link Longevity Maps Mental disorders Mood Disorders National Institute of Mental Health Neurodevelopmental Disorder Neurosciences Neurosciences Research Nursery Schools Outcomes Research Parents Participant Pathway interactions Pattern Preschool Child Prevalence Prevention Preventive Intervention Procedures Psychopathology Questionnaires Reporting Research Research Domain Criteria Research Proposals Rest Risk Sampling Schizophrenia Science Series Structure Technology Testing Time Toddler United States National Institutes of Health aged behavioral impairment brain behavior clinically relevant design flexibility infancy innovation neural circuit neuroimaging novel postnatal public health relevance relating to nervous system social social communication time interval vigilance

项目摘要

DESCRIPTION (provided by applicant): Infant Brain and Behavioral Signatures of Later Emerging Risk for Psychopathology Little is known about the trajectories of brain and behavioral development during infancy that anticipate and predict clinically impairing patterns of functioning observed during the preschool years. The prevalence of psychiatric symptomatology in preschool-aged children, combined with the possibility of common initializing pathophysiological events shared across various disorders, converge to highlight the infant and toddler period as uniquely suited for identifying atypical trajectories of brain and behavioral development that anticipate later emerging psychopathology. Characterizing trajectories that deviate from normative patterns of development during this time period may elucidate causal mechanisms of mental illness, mechanisms that subsequently could be targeted for strategic intervention/prevention. The proposed research will combine state-of-the-art neuroimaging technologies developed by the Human Connectome Project with a developmental approach to the NIMH Research Domain Criteria initiative. Longitudinal brain imaging (sMRI/DWI/fcMRI) and behavioral assessment (selected for relevance to later emerging psychopathology and acquired via direct assessment, parent report, and state-of-the art eye tracking procedures) will be conducted on 4 occasions between 3 and 15 months with a 5th assessment at 24 months of age. Dimensional aspects of clinically relevant behaviors will be characterized during a final 6th assessment between 30 and 36 months of age. The contribution of the proposed research is expected to be a comprehensive characterization of longitudinal brain development in the first years of life, coupled with a longitudinal characterization of behavioral constructs selected for their relevance to later emerging psychopathology. This contribution will be significant because the empirical data acquired will anchor a new paradigm of inquiry into the developmental processes that temporally precede the emergence of clinically impairing patterns of functioning, augmenting future efforts focused on strategic prevention of mental illness. The interdisciplinary synthesis that approaches clinical neuroscience or biological psychiatry from a developmental perspective represents an innovative departure from efforts designed to characterize neural signatures of DSM defined disorders examined years after the incipient pathophysiological events. More specifically, mapping trajectories of neural circuit development to behavioral constructs specifically selected for their relevance to later emerging psychopathology (Elison et al., 2013a; Elison et al., 2013b) highlights a novel developmental approach to the RDoC initiative. Indeed, these mappings will be characterized prior to the manifestation of clinically impairing patterns of functioning, and will be used to predict later emerging clinically relevant behaviors. Characterizing developmental signatures of later emerging psychopathology has the potential to alter the landscape of early identification and early intervention/prevention of psychiatric and neurodevelopmental disorders.

描述（由申请人提供）：婴儿大脑和行为特征的后期出现的精神病理风险，在婴儿时期的大脑和行为发展的轨迹，预测和预测临床功能损害模式所知甚少