Human cytomegalovirus in the promotion of glioblastoma multiforme pathogenesis

人巨细胞病毒促进多形性胶质母细胞瘤发病机制

• 批准号: 8758658
• 负责人: Michael James Strong
• 金额: $ 2.69万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8758658
• 关键词: Biology; Brain Neoplasms; Central Nervous System Neoplasms; Cytomegalovirus; Cytomegalovirus Infections; Development; Disease; Environment; Gene Expression Profile; Genes; Glioblastoma; Health; Human; Investigation; Lead; Link; Malignant Neoplasms; Mediating; Methods; Neuraxis; Oncogenic; Pathogenesis; Pathology; Pathway interactions; Patients; Phenotype; Process; RNA; Resolution; Role; Sampling; Signal Pathway; System; Technology; Therapeutic; Time; Vaccines; Validation; Virus; Virus Diseases; base; insight; interest; next generation sequencing; novel strategies; pathogen; transcriptome sequencing; tumor; tumor microenvironment

DESCRIPTION (provided by applicant): Viral infections are associated with several human malignancies, yet the role of viral infections in the central nervous system (CNS) tumors remains unclear. Although human cytomegalovirus (HCMV) has been associated with glioblastoma multiforme (GBM), the mechanisms of pathogenesis remain to be determined. GBM is the most common primary malignancy in the CNS, and unfortunately, it is also one of the most devastating. Novel approaches to studying this disease are paramount for the advancement in treatment options for patients with this dismal disease. Using robust next generation sequencing technology, this project aims to provide insight into HCMV biology related to GBMs. In addition, investigation of the tumor microenvironment for HCMV specific host cellular gene changes will lead to the discovery of pathways in which HCMV dysregulation promotes GBM pathology. The overarching hypothesis for this project is that HCMV contributes to GBM pathogenesis through modulation of the tumor microenvironment.

描述（由申请方提供）：病毒感染与几种人类恶性肿瘤相关，但病毒感染在中枢神经系统（CNS）肿瘤中的作用仍不清楚。虽然人巨细胞病毒（HCMV）与多形性胶质母细胞瘤（GBM）有关，但其发病机制仍有待确定。GBM是中枢神经系统中最常见的原发性恶性肿瘤，不幸的是，它也是最具破坏性的恶性肿瘤之一。研究这种疾病的新方法对于这种令人沮丧的疾病患者的治疗选择的进步至关重要。利用强大的下一代测序技术，该项目旨在深入了解与GBM相关的HCMV生物学。此外，对肿瘤微环境中HCMV特异性宿主细胞基因变化的研究将导致发现HCMV失调促进GBM病理的途径。该项目的总体假设是HCMV通过调节肿瘤微环境而促进GBM发病。