Developing a Lung Cancer Screening Registry in a State with a High Smoking Rate

描述（由申请人提供）：我们对国家肺部筛查试验（NLST）的结果将如何影响普通人群中使用低剂量计算机断层扫描（LDCT）进行肺癌筛查的了解存在空白。考虑到肺癌的高发病率和高死亡率，开发能够降低肺癌死亡率的筛查试验的效用的证据可能会显著改善公共卫生。长期目标是通过建立一个前瞻性的基于人群的注册表，收集患者、放射科医生和使用LDCT进行筛查的结果信息，来检查美国肺癌筛查的交付和质量。本应用程序的目的是对基于人群的肺癌筛查登记进行试点测试，并确定LDCT肺癌筛查在全州范围内的普及程度。我们计划通过以下两个具体目标来实现这些目标：(1)开发和实施建立基于人群的肺癌筛查登记所需的工具；(2)检查该州放射学实践中LDCT肺癌筛查的可用性。这项研究将

DESCRIPTION (provided by applicant): There is a gap in our knowledge of how the results of the National Lung Screening Trial (NLST) will impact the use of low dose computed tomography (LDCT) for lung cancer screening in the general population. Given the high incidence and mortality rates of lung cancer, developing evidence on the utility of a screening test that can reduce lung cancer mortality will likely lead to a significant improvement in public health. The long-term goal is to examine the delivery and quality of lung cancer screening across the U.S. by creating a prospective population based registry that captures patient, radiologist, and outcome information on the use of LDCT for screening. The objective of this application is to pilot test a population based lung cancer screening registry and determine the extent to which lung cancer screening with LDCT has diffused across the state. We plan to accomplish these objectives by pursuing the following two specific aims: (1) Develop and implement the tools required to establish a population-based lung cancer screening registry; and (2) Examine the availability of lung cancer screening with LDCT among radiology practices in the state. The study will focus on developing and implementing data collection elements as well as constructing a secure data entry system for capturing screening information from patients and radiologists. By conducting a survey of CT accredited radiology facilities we will investigate the characteristics o facilities currently performing screening in the state and also identify facilities for partnershipin the subsequent expansion phase. Currently, recommendations for LDCT for lung cancer screening are mixed, yet there is a growing need to monitor the screening experience as academic centers and community practices begin to adopt this technology for early detection in high-risk groups. This is an innovative pilot study that uses established methods in population based registry development and survey methodology to explore an emerging clinically relevant cancer screening area which is widely debated. The proposed research is significant because it will provide preliminary data on the use of LDCT for lung cancer screening in the non-clinical trial population and will also create a system for ongoing data capture that will inform the delivery and quality of lung cancer screening as this technology diffuses into the community.