Biobehavioral Influences on Cancer: Perspectives from Psychoneuroimmunology

描述（由申请人提供）：本K05申请从心理神经免疫学角度探讨生物行为对癌症的影响。炎症是大多数癌症的一个危险因素，在过去的十年里，它一直是Kiecolt-Glaser博士的主要免疫学研究重点。她目前资助的项目研究炎症在癌症相关疲劳中的作用，以及高饱和脂肪饮食后的餐后炎症如何成为慢性炎症反应的驱动因素。K05将允许PI在这一跨学科研究中促进新研究者和初级研究者的职业发展。K05还将通过提供必要的保护时间来获得人类营养和代谢方面的正式和非正式培训，使她的研究保持在前沿，并将允许她使用这些新知识来扩展和完善她的翻译工作，解决与炎症，肥胖和癌症相关的行为和营养之间的交叉点。她的实验室提供了一个优秀的训练环境。在基础科学和临床科学之间架起桥梁，她目前的资助工作采用多种方法，包括纵向观察研究、随机对照试验和精心设计的实验室范例。正式合作者包括免疫学家、病毒学家、内分泌学家、肿瘤学家、营养/饮食研究人员、心理学家和生物统计学家。这种广泛接触不同的范式和学科为学员提供了一个特殊的教育机会。她以前的研究生和博士后在获得优秀的教师职位和获得NIH资助方面非常成功。为了促进与癌症生存相关的生物行为问题的新研究人员和初级研究人员的职业发展，这是总体培训目标，她将与学员一起发展他们对相关文献和方法问题的知识，教他们批判性地分析研究并确定优势和劣势，指导他们提高科学写作技能和生产力的策略。并示范和促进他们与关键的跨学科合作者的互动。医学研究所的成员

DESCRIPTION (provided by applicant): This K05 application addresses biobehavioral influences on cancer from a psychoneuroimmunological perspective. Inflammation, a risk factor for most cancers, has been Dr. Kiecolt-Glaser's primary immunological focus during the last decade. Her current funded projects address the role of inflammation in cancer-related fatigue, as well as questions about how postprandial inflammation following meals high in saturated fat may act as a driver for chronic inflammatory responses. The K05 will allow the PI 1) to promote the career development of new and junior investigators in this transdisciplinary research. The K05 will also keep her research at the cutting edge by providing the protected time necessary 2) to obtain formal and informal training in human nutrition and metabolism, and will allow her 3) to use this new knowledge to expand and refine her translational work that addresses the intersection between behavior and nutrition relevant to inflammation, obesity, and cancer. Her laboratory provides an outstanding training environment. Bridging basic and clinical science, her current funded work utilizes diverse methodologies including longitudinal observational studies, randomized controlled trials, and elaborate laboratory paradigms. Formal collaborators include immunologists, virologists, endocrinologists, oncologists, nutritional/dietary researchers, psychologists, and biostatisticians. This broad exposure to diverse paradigms and disciplines provides an exceptional educational opportunity for mentees. Her former graduate students and postdoctoral fellows have been extremely successful in securing excellent faculty positions and obtaining NIH funding. To promote the career development of new and junior investigators in biobehavioral issues related to cancer survivorship, the overarching training goal, she will work with trainees to develop their knowledge of relevant literature and methodological issues, teach them to critically analyze research and identify strengths and weaknesses, tutor them in strategies for enhanced skill and productivity in scientific writing, and model and promote their interactions with key interdisciplinary collaborators. A member of the Institute of Medicine of the National Academy of Sciences, Dr. Kiecolt-Glaser is a senior and well-established researcher who has demonstrated a sustained, high level of research and mentoring productivity. This K05 will relieve the PI of substantial administrative responsibilities and make it possible to commit 25% of her total effort to mentoring younger scientists who can make notable contributions to our understanding of biobehavioral influences in cancer survivorship from a psychoneuroimmunological perspective, as well as additional research time to newer research efforts related to nutritional influences on behavioral, endocrine, and immune system interactions that affect cancer risk and clinical outcomes.