Marital Discord, Fast Food, Obesity, and Inflammation

婚姻不和、快餐、肥胖和炎症

基本信息

  • 批准号:
    8257918
  • 负责人:
  • 金额:
    $ 19.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-04-14 至 2014-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Diet clearly impacts inflammation; about one-third of the total energy intake in the US population comes from fast food consumption that is typically high in saturated fat, and recent demonstrations of enhanced inflammation following meals high in saturated fats have sparked interest in the possibility that postprandial inflammation acts as a driver for chronic inflammatory responses; when high-fat, fast-food-type meals flood the body with simple carbohydrates and triglycerides, the meals may also provoke spikes in IL-6 and CRP while enhancing oxidative stress and sympathetic hyperactivity. Furthermore, proinflammatory responses to high-fat meals are exaggerated by obesity, particularly visceral adiposity, and high-fat meals push obesity's characteristic elevated inflammation levels even higher and sustain them longer. Depression and psychosocial stress can also directly promote proinflammatory cytokine production, and a turbulent marriage is a rich source for both; marital discord greatly enhances risk for depression, and marital discord also has notable physiological repercussions as documented by its association with poorer clinical outcomes for inflammation-related conditions including cardiovascular disease and metabolic syndrome. A series of well-controlled laboratory studies have provided important mechanistic data; negative or hostile behavior during marital conflict (a hallmark of marital discord) substantially augments adverse endocrine and immune changes, including enhanced production of proinflammatory cytokines. Drawing on behavioral, nutritional, and immunological research, this double-blind, randomized crossover trial will assess changes in inflammation and mood following a fast-food-type meal compared to a healthier meal (moderate level of fats) in distressed and nondistressed couples. Couples will be asked to discuss and resolve a disagreement following both meals to maximize the salience and impact of marital distress on meal- related inflammatory responses; behavioral coding of these interactions will provide data on hostile marital behaviors. Our primary aim is to characterize the impact of a fast-food-type meal compared to a healthier meal on postprandial inflammatory responses in distressed and nondistressed couples, and to appraise the relative impact of central adiposity as a predictor of inflammatory responses. Our secondary, exploratory aim is to assess the relative contributions of gender and negative or hostile marital behaviors to depressive symptoms and inflammatory responses at baseline, as well as following the meal challenge. This proposal provides a new perspective on the biobehavioral pathways through which obesity, diet, and marital discord interact to promote inflammation. Elevated levels of proinflammatory cytokines are associated with cancer risk, depression, cardiovascular disease, osteoporosis, arthritis, Type II diabetes, and frailty and functional decline, underscoring the broad clinical relevance. PUBLIC HEALTH RELEVANCE: This project seeks to lay the foundation for translational research that would enhance our understanding of the biobehavioral pathways through which obesity, diet, and marital discord interact to promote inflammation. The evidence that fast food-type meals promote postprandial dysmetabolism is relatively recent and still preliminary, but the possibility that postprandial inflammation acts as a driver for chronic inflammation is clearly important. Elevated levels of proinflammatory cytokines are associated with cancer risk, depression, cardiovascular disease, osteoporosis, arthritis, Type II diabetes, and frailty and functional decline, underscoring the broad clinical relevance.
描述(由申请人提供):饮食明显影响炎症;美国人口中总能量摄入的约三分之一来自通常饱和脂肪含量高的快餐消费,并且最近证明在饱和脂肪含量高的膳食后炎症增强,这引发了人们对餐后炎症作为慢性炎症反应驱动因素的可能性的兴趣;当高脂肪、快餐型膳食使身体充满简单的碳水化合物和甘油三酯时,膳食也可能引起IL-6和CRP的峰值,同时增强氧化应激和交感神经亢进。此外,对高脂肪膳食的促炎反应被肥胖症,特别是内脏肥胖症夸大,高脂肪膳食将肥胖症的特征性炎症水平推得更高,并维持更长时间。 抑郁症和心理压力也可以直接促进促炎细胞因子的产生,而动荡的婚姻是两者的丰富来源;婚姻不和谐大大增加了抑郁症的风险,婚姻不和谐也有显着的生理影响,如其与炎症相关疾病(包括心血管疾病和代谢综合征)的临床结果较差相关。一系列控制良好的实验室研究提供了重要的机制数据;婚姻冲突期间的消极或敌对行为(婚姻不和谐的标志)大大增加了不良的内分泌和免疫变化,包括促炎细胞因子的产生增加。 根据行为,营养和免疫学研究,这项双盲,随机交叉试验将评估与健康膳食(中等脂肪水平)相比,快餐型膳食后炎症和情绪的变化。夫妇将被要求在两餐后讨论和解决分歧,以最大限度地提高婚姻痛苦对膳食相关炎症反应的显着性和影响;这些互动的行为编码将提供敌对婚姻行为的数据。我们的主要目的是描述快餐型膳食与健康膳食相比对痛苦和非痛苦夫妇餐后炎症反应的影响,并评估中枢性肥胖作为炎症反应预测因子的相对影响。我们的第二个探索性目标是评估性别和消极或敌对的婚姻行为对基线时以及餐后抑郁症状和炎症反应的相对贡献。这一提议为肥胖、饮食和婚姻不和相互作用促进炎症的生物行为途径提供了一个新的视角。促炎细胞因子水平升高与癌症风险、抑郁症、心血管疾病、骨质疏松症、关节炎、II型糖尿病以及虚弱和功能下降相关,强调了广泛的临床相关性。 公共卫生关系:该项目旨在为转化研究奠定基础,以增强我们对肥胖,饮食和婚姻不和谐相互作用促进炎症的生物行为途径的理解。快餐类食物促进餐后代谢异常的证据相对较新,仍然是初步的,但餐后炎症作为慢性炎症驱动因素的可能性显然很重要。促炎细胞因子水平升高与癌症风险、抑郁症、心血管疾病、骨质疏松症、关节炎、II型糖尿病以及虚弱和功能下降相关,强调了广泛的临床相关性。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cortisol slopes and conflict: A spouse's perceived stress matters.
  • DOI:
    10.1016/j.psyneuen.2020.104839
  • 发表时间:
    2020-11
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Shrout MR;Renna ME;Madison AA;Jaremka LM;Fagundes CP;Malarkey WB;Kiecolt-Glaser JK
  • 通讯作者:
    Kiecolt-Glaser JK
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JANICE KIECOLT-GLASER其他文献

JANICE KIECOLT-GLASER的其他文献

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{{ truncateString('JANICE KIECOLT-GLASER', 18)}}的其他基金

Spousal Dementia Caregivers: Risk for Accelerated Aging
配偶痴呆症照顾者:加速衰老的风险
  • 批准号:
    10054999
  • 财政年份:
    2020
  • 资助金额:
    $ 19.9万
  • 项目类别:
Spousal Dementia Caregivers: Risk for Accelerated Aging
配偶痴呆症照顾者:加速衰老的风险
  • 批准号:
    10261514
  • 财政年份:
    2020
  • 资助金额:
    $ 19.9万
  • 项目类别:
Marital quality and longevity: Biobehavioral pathways
婚姻质量和寿命:生物行为途径
  • 批准号:
    10212929
  • 财政年份:
    2017
  • 资助金额:
    $ 19.9万
  • 项目类别:
Marital quality and longevity: Biobehavioral pathways
婚姻质量和寿命:生物行为途径
  • 批准号:
    10415278
  • 财政年份:
    2017
  • 资助金额:
    $ 19.9万
  • 项目类别:
Aerobic Capacity, Depression, & Inflammatory Responsivity in Cancer Survivors
有氧能力、抑郁、
  • 批准号:
    8891741
  • 财政年份:
    2015
  • 资助金额:
    $ 19.9万
  • 项目类别:
Aerobic Capacity, Depression, & Inflammatory Responsivity in Cancer Survivors
有氧能力、抑郁、
  • 批准号:
    9111815
  • 财政年份:
    2015
  • 资助金额:
    $ 19.9万
  • 项目类别:
Breast Cancer Survivors Cardiovascular Risks: Treatment and Behavioral Influences
乳腺癌幸存者的心血管风险:治疗和行为影响
  • 批准号:
    8716979
  • 财政年份:
    2014
  • 资助金额:
    $ 19.9万
  • 项目类别:
Breast Cancer Survivors Cardiovascular Risks: Treatment and Behavioral Influences
乳腺癌幸存者的心血管风险:治疗和行为影响
  • 批准号:
    9379087
  • 财政年份:
    2014
  • 资助金额:
    $ 19.9万
  • 项目类别:
Breast Cancer Survivors Cardiovascular Risks: Treatment and Behavioral Influences
乳腺癌幸存者的心血管风险:治疗和行为影响
  • 批准号:
    8850411
  • 财政年份:
    2014
  • 资助金额:
    $ 19.9万
  • 项目类别:
Breast Cancer Survivors Cardiovascular Risks: Treatment and Behavioral Influences
乳腺癌幸存者的心血管风险:治疗和行为影响
  • 批准号:
    9248003
  • 财政年份:
    2014
  • 资助金额:
    $ 19.9万
  • 项目类别:

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