Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease

用于视网膜血管疾病非侵入性成像的相差 OCT

• 批准号: 8658435
• 负责人: SCOTT E FRASER
• 金额: $ 39.65万
• 依托单位: VISDEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8658435
• 关键词: Age; Algorithmic Software; Algorithms; American; Angiography; Blindness; Blood Circulation; Blood Vessels; Blood capillaries; Caring; Choroidal Neovascularization; Classification; Clinical; Communities; Computer software; Consult; Data; Data Analyses; Detection; Development; Diabetic Retinopathy; Diagnosis; Diagnostic; Diagnostic tests; Disease; Dyes; Early Diagnosis; Evaluation; Eye; Financial compensation; Fluorescein Angiography; Fundus photography; Goals; Gold; Image; Image Analysis; Imagery; Imaging Device; Imaging technology; Informatics; Lead; Legal patent; Macular degeneration; Methods; Microaneurysm; Motion; Mydriasis; Ophthalmologist; Optical Coherence Tomography; Optics; Optometrist; Outcome; Patients; Performance; Phase; Process; Provider; Pupil; Reading; Research; Research Infrastructure; Resolution; Retinal; Retinal Neovascularization; Secondary to; Solutions; Specialist; Speed; System; Techniques; Technology; Time; Vascular Diseases; Visual; Work; capillary; commercial application; cost; design; head-to-head comparison; high risk; imaging modality; improved; instrument; intravenous injection; neovascularization; non-invasive imaging; public health relevance; screening; software development; tool; visual feedback

DESCRIPTION (provided by applicant): Since its introduction in the 1960's, fluorescein angiography (FA) has been the gold standard for retinal vascular diagnosis. However, FA is costly, invasive, and time-consuming, which limits its usefulness as a screening tool. As a potential non-invasive alternative to FA for diagnosing retinovascular disease, we have developed an imaging method called phase contrast optical coherence tomography (PC-OCT). Our technology uses specialized software analysis of data acquired from clinically available optical coherence tomography imaging systems to provide an additional functionality of three-dimensional angiography. The majority of eye care in the US is currently performed by optometrists, and in many underserved communities, they are the sole providers. Unfortunately, most optometrists cannot perform FA due to its requirement for intravenous injection. Therefore, retinal vascular diagnostics are limited to clinical exam and fundus photography. Patients receiving optometric care would benefit from a non-invasive alternative to FA for improved screening of retinovascular diseases, especially in these underserved communities. PC-OCT has the potential to provide a low-cost and convenient vascular screening method, which could result in timely referrals to retinal specialists, as well as improved visual outcomes. To advance PC-OCT as a retinovascular imaging tool, we have the following goals: (1) develop PC-OCT software into a faster automated platform for application to commercial spectral domain (SD-OCT) systems; (2) optimize optical scanner performance for imaging both dilated and non-dilated pupils; and (3) demonstrate the feasibility of PC-OCT as a wide-field screening diagnostic for diabetic retinopathy. The visualization capabilities of PC-OCT imaging will be compared directly against fundus photography, the current diagnostic standard for eye care professionals. Successful completion of Phase II will result in an automated software package capable of producing PC-OCT microvascular images from the raw data of a commercial SD-OCT system, allowing for convenient vascular imaging accessible to all eye care practitioners. This could lead to better-quality detection capabilities for retinovascular disease and potentially improved visual outcomes.

描述（由申请人提供）：自 20 世纪 60 年代推出以来，荧光素血管造影 (FA) 一直是视网膜血管诊断的金标准。然而，FA 成本高昂、具有侵入性且耗时，这限制了其作为筛查工具的实用性。作为诊断视网膜血管疾病的 FA 的潜在非侵入性替代方案，我们开发了一种称为相衬光学相干断层扫描 (PC-OCT) 的成像方法。我们的技术使用专门的软件分析从临床可用的光学相干断层扫描成像系统获取的数据，以提供三维血管造影的附加功能。目前，美国的大部分眼科护理都是由验光师进行的，在许多服务不足的社区，他们是唯一的提供者。不幸的是，由于 FA 需要静脉注射，大多数验光师无法进行 FA。因此，视网膜血管诊断仅限于临床检查和眼底摄影。接受验光护理的患者将受益于 FA 的非侵入性替代方案，以改善视网膜血管疾病的筛查，特别是在这些服务不足的社区。 PC-OCT 有潜力提供一种低成本且方便的血管筛查方法，从而可以及时转诊给视网膜专家，并改善视力结果。为了将 PC-OCT 发展为视网膜血管成像工具，我们有以下目标：（1）将 PC-OCT 软件开发成更快的自动化平台，以应用于商业谱域（SD-OCT）系统； (2) 优化光学扫描仪对散瞳和非散瞳成像的性能； (3) 证明 PC-OCT 作为糖尿病视网膜病变广域筛查诊断的可行性。 PC-OCT 成像的可视化功能将直接与眼底摄影（眼保健专业人员当前的诊断标准）进行比较。第二阶段的成功完成将产生一个自动化软件包，能够根据商业 SD-OCT 系统的原始数据生成 PC-OCT 微血管图像，从而为所有眼保健从业人员提供方便的血管成像。这可能会带来更好质量的视网膜血管疾病检测能力，并有可能 改善视觉效果。