Investigating the cellular requirement for STIM1 phosphorylation and store-operated calcium entry suppression during mitosis: roles in development and cancer

研究有丝分裂过程中 STIM1 磷酸化和钙池操纵的钙进入抑制的细胞需求：在发育和癌症中的作用

• 批准号: nhmrc : 1071074
• 负责人: Dr Felicity Davis
• 金额: $ 23万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-cellular-requirement-development-cancer/455454
• 关键词: Investigating; cellular; requirement; STIM1; phosphorylation

Cells are constantly interacting with and modifying their surrounding environment. The intracellular calcium signal is one mechanism cells use to translate signals from the microenvironment into cellular responses. This proposal seeks to explore why a key calcium signalling pathway, known as store-operated calcium entry, is specifically silenced during cell division, and to determine how reversing this inhibition affects cell division during normal development and in cancer.

细胞不断地与周围环境相互作用和改变。细胞内钙信号是细胞将微环境中的信号转化为细胞反应的一种机制。这项建议试图探索为什么一个关键的钙信号通路，即所谓的存储操作的钙进入，在细胞分裂期间被特别沉默，并确定逆转这种抑制如何影响正常发育期间和癌症中的细胞分裂。