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Investigating the cellular requirement for STIM1 phosphorylation and store-operated calcium entry suppression during mitosis: roles in development and cancer

Investigating the cellular requirement for STIM1 phosphorylation and store-operated calcium entry suppression during mitosis: roles in development and cancer
研究有丝分裂过程中 STIM1 磷酸化和钙池操纵的钙进入抑制的细胞需求:在发育和癌症中的作用
批准号:
nhmrc : 1071074
负责人:
Dr Felicity Davis
金额:
$23.0万
依托单位国家:
澳大利亚
项目类别:
Early Career Fellowships
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2018-12-31

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中文摘要
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英文摘要
Cells are constantly interacting with and modifying their surrounding environment. The intracellular calcium signal is one mechanism cells use to translate signals from the microenvironment into cellular responses. This proposal seeks to explore why a key calcium signalling pathway, known as store-operated calcium entry, is specifically silenced during cell division, and to determine how reversing this inhibition affects cell division during normal development and in cancer.
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Identifying and exploiting novel pharmacological targets for breast cancer treatment
  • 批准号:
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  • 项目类别:
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    $44.22万
  • 财政年份:
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Identifying and exploiting novel pharmacological targets for breast cancer
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Identifying and exploiting novel pharmacological targets for breast cancer
  • 批准号:
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  • 项目类别:
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  • 资助金额:
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  • 负责人:
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Identifying and exploiting novel pharmacological targets for breast cancer treatment
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  • 项目类别:
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  • 负责人:
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