Clinical Coordinating Center for the Severe Asthma Research Program (SARP)

严重哮喘研究计划临床协调中心 (SARP)

• 批准号: 8914737
• 负责人: David T. Mauger
• 金额: $ 49.1万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-08 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8914737
• 关键词: Adult; Affect; Asthma; Biological Markers; Child; Childhood Asthma; Clinical; Clinical Research; Communication; Data Collection; Data Coordinating Center; Disease; Doctor of Philosophy; Education; Epigenetic Process; Funding; Genetic; Genomics; Goals; Head; Health Sciences; Home environment; Human Resources; Instruction; Leadership; Maintenance; Medicine; Molecular; Performance; Phenotype; Process; Productivity; Protocols documentation; Public Health; Qualifying; Quality Control; Recording of previous events; Research; Research Personnel; Risk; Scholarship; Symptoms; System; Time; United States; Work; base; college; cost effective; data management; design; experience; infrastructure development; operation; programs; repository; tool

DESCRIPTION (provided by applicant): The overall goal of the Severe Asthma Research Program (SARP) is to develop a new paradigm for the understanding of severe asthma and its sub-phenotypes, in children and adults, by defining disease longitudinally at the molecular and cellular level. The Department of Public Health Sciences at the Penn State College of Medicine proposes to serve as the Clinical Coordinating Center (CCC) for SARP. The CCC will provide biostatistical leadership and scientific coordination for SARP; design and maintain the SARP operations management system; provide logistical and communications support for SARP; and distribute funds for a shared longitudinal protocol. The Department of Public Health Sciences is uniquely qualified to serve as the Clinical Coordinating Center for SARP, as the home of the Asthma Clinical Research Network (ACRN) and the Childhood Asthma Research and Education (CARE) Data Coordinating Centers since their inceptions in 1993 and 1999, respectively, and the AsthmaNet DCC since 2009. The PI and core biostatistician of this application is David T. Mauger, PhD, who is currently the PI of the CARE and Asthma Net DCCs. Dr. Mauger will head a DPHS team well-experienced in data collection and management, biostatistical design and analysis, quality control, network infrastructure development and maintenance, and working with national repositories and oversight committees. This application also includes a very strong clinical co-investigator with extensive research experience in asthma, Joanna Floros, PhD. Although there will be many clinician investigators at the network clinical centers who are leaders in the field, frequent, direct interaction between CCC personnel and local co-investigators with clinical expertise greatly facilitates the activities of the CCC. In summary, through its long history of managing successful data coordinating centers, Penn State College of Medicine's Department of Public Health Sciences is well poised to successfully implement and execute the Severe Asthma Research Program.

描述（由申请人提供）：严重哮喘研究计划（SARP）的总体目标是通过在分子和细胞水平上纵向定义疾病，开发一种新的范例，以了解儿童和成人的严重哮喘及其亚表型。宾夕法尼亚州立大学医学院公共卫生科学系提议担任 SARP 的临床协调中心 (CCC)。 CCC 将为 SARP 提供生物统计领导和科学协调；设计和维护SARP运营管理系统；为标准和建议措施（SARP）提供后勤和通讯支持；并为共享纵向协议分配资金。 公共卫生科学系具有作为 SARP 临床协调中心的独特资格，自 1993 年和 1999 年成立以来，分别作为哮喘临床研究网络 (ACRN) 和儿童哮喘研究和教育 (CARE) 数据协调中心的所在地，以及自 2009 年以来 AsthmaNet DCC 的所在地。该应用程序的 PI 和核心生物统计学家是 David T. Mauger 博士，谁是 目前是 CARE 和 Asthma Net DCC 的 PI。 Mauger 博士将领导 DPHS 团队，该团队在数据收集和管理、生物统计设计和分析、质量控制、网络基础设施开发和维护以及与国家存储库和监督委员会的合作方面经验丰富。该申请还包括一位在哮喘领域拥有丰富研究经验的非常强大的临床联合研究员 Joanna Floros 博士。尽管网络临床中心会有许多临床研究人员是该领域的领导者，但 CCC 人员与具有临床专业知识的当地共同研究人员之间频繁、直接的互动极大地促进了 CCC 的活动。 总之，凭借其管理成功数据协调中心的悠久历史，宾夕法尼亚州立大学医学院公共卫生科学系已做好准备，成功实施和执行严重哮喘研究计划。