Mechanisms that mediate the link between lead exposure and child behavior problem

介导铅暴露与儿童行为问题之间联系的机制

• 批准号: 8089020
• 负责人: JIANGHONG LIU
• 金额: $ 13.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089020
• 关键词: Accounting; Achievement; Adolescent; Adult; Affect; Affective; Age; Aggressive behavior; Attention deficit hyperactivity disorder; Award; Behavior; Behavioral; Biosocial; Brain; Centers for Disease Control and Prevention (U.S.); Child; Child Behavior; Childhood; Clinical; Cognitive; Cognitive deficits; Cohort Studies; Communities; Competence; Cross-Sectional Studies; Data; Development; Developmental Process; Dietary Intervention; Dietary Supplementation; Disease; Effectiveness; Emotional; Environment; Family; Fostering; Functional disorder; Funding; Future; Galvanic Skin Response; Goals; Impaired cognition; Impairment; Independent Scientist Award; Individual; Interdisciplinary Study; International; Knowledge; Lead; Link; Long-Term Effects; Measurement; Mediating; Mediator of activation protein; Metals; National Institute of Environmental Health Sciences; Neurobiology; Neurocognitive; Neurotoxins; Nursery Schools; Omega-3 Fatty Acids; Outcome; P300 Event-Related Potentials; Parenting behavior; Performance; Prevention; Prevention strategy; Preventive Intervention; Problem behavior; Procedures; Process; Psychopathology; Psychophysiology; Public Health; Quality of life; Relative (related person); Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Sampling; Schools; Scientist; Senior Scientist; Statistical Models; Stress; Supplementation; Testing; Time; Toxic Environmental Substances; Toxic effect; Training; Translating; Translational Research; United States National Institutes of Health; Violence; base; blood lead; career development; clinical practice; conditioned fear; early adolescence; experience; externalizing behavior; improved; lead exposure; neurobiological mechanism; neurotoxic; preadolescence; prevent; programs; prospective; psychosocial; research and development; skills; social; theories

DESCRIPTION (provided by applicant) We currently lack knowledge on the intermediary mechanisms whereby lead exposure translates itself into increased behavior problems in childhood. This K02 Independent Scientist Development Award application will enable the candidate to develop an interdisciplinary program of research whose overarching goal is to uncover the cognitive and affective mechanisms of action underlying lead exposure-behavior problems relationship in a large sample of community children. This research program questions the current CDC "safe" standard of 10 ug/dl of lead, and hypothesizes that early sub-clinical lead exposure results in negative clinical, cognitive, and affective functioning. Building on an NIEHS-funded community preschool cohort study, the investigators will first propose to repeat measurements of both blood lead levels and behavioral outcomes to assess whether children with sustained sub-clinical blood lead levels across time are especially likely to develop externalizing behavior problems. Second, the investigators aim to understand how lead exposure interacts with social risk factors in predisposing to externalizing behavior problems. Third, and importantly, they propose to elucidate the neurocognitive and affective mediating mechanisms by which lead exposure during the preschool years contribute to externalizing behavior problems in early adolescence. This K02 will help foster the candidate's ability to achieve these research goals by providing her with protected time to collaborate more closely with senior scientists in the field, to be more fully engaged in her NIH- funded international research project on this sample, and to enhance her interdisciplinary knowledge and skills in development psychopathology, environmental toxicity, psycho-physiological testing, and advanced statistical analysis. Programmatically, the K02 will be of critical value in moving her into a new line of interdisciplinary research on prevention and intervention of behavior problems by giving her time to develop a nutritional intervention for preventing and treating behavior problems in lead-exposed children. This research program consequently has the potential to help redefine what level of lead exposure is safe, identify hitherto unknown mechanisms of action, and reduce childhood behavior problems throughout the community.

描述（由申请人提供）