Antigenic switch in bacterial adhesins
细菌粘附素的抗原转换
基本信息
- 批准号:8695287
- 负责人:
- 金额:$ 19.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-05 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAdhesivesAffectAffinityAntibodiesAntibody FormationAntigenic SwitchingAntigensBackBacteriaBacterial AdhesinsBacterial AdhesionBindingCell AdhesionCell surfaceDockingEscherichia coliEscherichia coli AdhesinsEscherichia coli InfectionsExhibitsFimbriae ProteinsFimbrial AdhesinsGoalsImmune responseLectinLigandsMannoseMannose Binding LectinMannose-Binding LectinsMechanicsMediatingMolecularMolecular AnalysisMolecular ConformationMonoclonal AntibodiesNaturePathogenesisPathogenicityPhysiologicalPropertyProteinsResearchRoleSpecificityStructureSurfaceTimeUrinary tract infectionUropathogenic E. coliVaccinesVariantVirulence Factorsbasenovel strategiespolyclonal antibodypreventpublic health relevancereceptorresponsetype 1 fimbriaevaccine candidate
项目摘要
DESCRIPTION (provided by applicant): The primary goal of this proposal is to understand how allosteric conformational properties of the most common, type 1 fimbrial adhesin of E. coli defines its role in the pathogenesis of urinary tract infections. FimH is an adhesive subunit of th type 1 fimbriae and is one of the major factors in the ability of E. coli to cause urinary tract infection. We determined that the mannose-binding lectin domain of FimH can assume two conformational states - with a high- and low-affinity towards terminally-exposed mannosyl residues. The conformational shift in FimH is highly dynamic in nature and is the basis of the ability of FimH to mediate shear-enhanced bacterial adhesion. We intend to analyze the conformational switch in FimH in the context of the immune response against the adhesive protein.
描述(由申请人提供):本提案的主要目标是了解大肠杆菌最常见的1型菌毛粘附素的变构构象特性如何定义其在尿路感染发病机制中的作用。FimH是1型菌毛的粘附亚基,是大肠杆菌引起尿路感染的主要因素之一。我们确定了FimH的甘露糖结合凝集素结构域可以呈现两种构象状态-对终端暴露的甘露糖基残基具有高亲和力和低亲和力。FimH的构象变化本质上是高度动态的,是FimH介导剪切增强细菌粘附能力的基础。我们打算在免疫反应中分析FimH的构象开关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
EVGENI Veniaminovic SOKURENKO其他文献
EVGENI Veniaminovic SOKURENKO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('EVGENI Veniaminovic SOKURENKO', 18)}}的其他基金
Rapid Genetic Fingerprinting of SARS-Cov-2 Variants
SARS-Cov-2 变体的快速基因指纹分析
- 批准号:
10330879 - 财政年份:2021
- 资助金额:
$ 19.31万 - 项目类别:
Mechanism of the Fluoroquinolone Resistance Acquisition in Enterobacteria
肠杆菌对氟喹诺酮类耐药的获得机制
- 批准号:
10598528 - 财政年份:2021
- 资助金额:
$ 19.31万 - 项目类别:
Mechanism of the Fluoroquinolone Resistance Acquisition in Enterobacteria
肠杆菌对氟喹诺酮类耐药的获得机制
- 批准号:
10383691 - 财政年份:2021
- 资助金额:
$ 19.31万 - 项目类别:
Recombinant Fc fusions for treatment of uropathogenic E. coli
用于治疗尿路致病性大肠杆菌的重组 Fc 融合体
- 批准号:
10021217 - 财政年份:2020
- 资助金额:
$ 19.31万 - 项目类别:
Role of type 1 fimbrial mutations in the pathogenesis of pandemic E. coli
1 型菌毛突变在大流行性大肠杆菌发病机制中的作用
- 批准号:
9975702 - 财政年份:2019
- 资助金额:
$ 19.31万 - 项目类别:
相似海外基金
I-Corps: Translation Potential of Peptidic Ensembles as Novel Bio-adhesives
I-Corps:肽整体作为新型生物粘合剂的转化潜力
- 批准号:
2409620 - 财政年份:2024
- 资助金额:
$ 19.31万 - 项目类别:
Standard Grant
Architectural design of active adhesives
活性粘合剂的结构设计
- 批准号:
2403716 - 财政年份:2024
- 资助金额:
$ 19.31万 - 项目类别:
Standard Grant
Design of non-swellable adhesives for brain surgery using cyclodextrin inclusion polymer
使用环糊精包合物聚合物脑外科不可溶胀粘合剂的设计
- 批准号:
23H01718 - 财政年份:2023
- 资助金额:
$ 19.31万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Meta-material adhesives for improved performance and functionalisation of bondlines
超材料粘合剂可提高粘合层的性能和功能化
- 批准号:
EP/W019450/1 - 财政年份:2023
- 资助金额:
$ 19.31万 - 项目类别:
Fellowship
Light-propelled dental adhesives with enhanced bonding capability
具有增强粘合能力的光驱动牙科粘合剂
- 批准号:
10741660 - 财政年份:2023
- 资助金额:
$ 19.31万 - 项目类别:
DMREF: Accelerating the Design of Adhesives with Nanoscale Control of Thermomechanical Properties
DMREF:通过热机械性能的纳米级控制加速粘合剂的设计
- 批准号:
2323317 - 财政年份:2023
- 资助金额:
$ 19.31万 - 项目类别:
Continuing Grant
Mag-Cure: A novel method for magnetically induced bonding and de-bonding of thermoset adhesives in the Automotive Industry
Mag-Cure:汽车行业中热固性粘合剂磁感应粘合和脱粘的新方法
- 批准号:
10062336 - 财政年份:2023
- 资助金额:
$ 19.31万 - 项目类别:
Collaborative R&D
Biodegradable, Biocompatible Pressure Sensitive Adhesives
可生物降解、生物相容性压敏粘合剂
- 批准号:
10677869 - 财政年份:2022
- 资助金额:
$ 19.31万 - 项目类别:
Poly(glycerol carbonate) pressure sensitive adhesives for the in vivo closure of alveolar pleural fistulae
用于体内闭合肺泡胸膜瘘的聚(甘油碳酸酯)压敏粘合剂
- 批准号:
10746743 - 财政年份:2022
- 资助金额:
$ 19.31万 - 项目类别:
Enhanced bio-production of difficult to make peptide ingredients for specialty adhesives and personal care
增强用于特种粘合剂和个人护理品的难以制造的肽成分的生物生产
- 批准号:
10021363 - 财政年份:2022
- 资助金额:
$ 19.31万 - 项目类别:
Investment Accelerator