Comparative Efficacy of HIV-Prevention among Youth with Mental Health Needs

有心理健康需求的青少年艾滋病毒预防的比较效果

• 批准号: 8727174
• 负责人: DAVID Heaton BARKER
• 金额: $ 16.92万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727174
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adolescence; Adolescent; Adolescent Risk Behavior; Adolescent and Young Adult; Affect; Age; Alcohol or Other Drugs use; Ambulatory Care; Area; Attention; Behavior; Behavior assessment; Behavior monitoring; Behavioral; Characteristics; Child; Clinical; Clinical Trials; Collaborations; Complex; Data; Data Set; Databases; Development; Dimensions; Educational workshop; Emotional; Family Process; Foundations; Funding; Future; Goals; Grant; HIV; HIV prevention trial; HIV risk; Head; Hospitals; Individual; Intervention; K-Series Research Career Programs; Learning; Link; Manuscripts; Measurement; Measures; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Metric; Modeling; Outcome; Parenting behavior; Parents; Policy Maker; Population; Positioning Attribute; Preparation; Prevention; Prevention approach; Prevention program; Prevention strategy; Process; Psychopathology; Reading; Regulation; Relative (related person); Research; Research Design; Resources; Rhode Island; Risk; Risk Behaviors; Risk Factors; Sample Size; Sampling; Schools; Scientist; Sex Behavior; Sexual Partners; Signal Transduction; Statistical Models; Structure; Subgroup; Target Populations; Techniques; Testing; Therapeutic; Training; United States; United States National Institutes of Health; Universities; Vulnerable Populations; Work; Youth; adolescent substance use; base; career; communication behavior; comparative efficacy; cost effective; design; efficacy research; experience; family management; follow-up; improved; meetings; multidisciplinary; permissiveness; programs; prospective; public health relevance; sex; sex risk; sexual debut; sexual minority; skills; skills training; social; young adult

DESCRIPTION (provided by applicant): This Mentored Research Scientist Career Development Award will provide Dr. David Barker with focused training to enable him to leverage modern statistical modeling methods in identifying promising areas of intervention, and to collaborate with multidisciplinary teams to implement effective HIV-prevention programs for adolescents and young adults. One challenge to the effective dissemination of existing prevention programs is the limited understanding of who responds or does not respond to a given program. Providing such information to policy makers and program directors will help match existing prevention programs to the needs of target populations. Identifying which prevention program works best for which subgroups of youth requires sophisticated statistical modeling and large samples to identify and describe the subgroups. Combining across studies is a cost-effective way to increase the sample size of individual trials. However, combining data introduces complexity due to differences in how studies are designed and in how key outcomes are collected, analyzed and interpreted. The proposed research combines data from five NIH-funded trials of HIV-prevention programs for youth with mental health concerns to compare the efficacy of the programs and identify which youth respond or do not respond to current programs. The proposed research assists Dr. Barker in achieving his career and training goals to: (1) learn modern modeling approaches to address complex data structures that arise when combining multiple datasets, (2) learn methods for drawing causal inferences when integrating data across multiple clinical trials, (3) learn methods to compare the efficacy of prevention programs not tested in a "head-to-head" trial, (4) extend his training in HIV-risk prevention to key vulnerable populations identified in the National HIV/AIDS Strategy for the United States, namely substance using populations and sexual minority populations, (5) develop a program of research that utilizes existing data to identify promising areas for improving prevention efforts, and (6) develop collaborations with prominent scientist involved in HIV-prevention to develop high-quality research manuscripts and grants. The specific aims of the proposed research are to (1) build a database that links data from 5 NIH-funded prospective HIV-prevention trials, (2) Apply consistent analyses across the 5 trials by jointly modeling the multiple dimensions of adolescent sexual risk behavior, (3) compare the efficacy of current prevention programs for youth with mental health concerns, and (4) Identify and describe subgroups of adolescents with mental health concerns who responded or did not respond to each prevention approach. These aims will be achieved by using the skills learned through this K23 mechanism to address the analytic complexities of combining data across multiple prevention trials. Training will include a combination of didactic coursework, workshops, and mentoring by a team of experts in modern analytic approaches and HIV-prevention. The mentoring will include tailored reading assignments, regular face-to-face meetings, mentored research, and collaborative projects and manuscripts. The training received through this K23 application will place Dr. Barker in a position to collaborate with prominent HIV-prevention scientists in funded research focused on leveraging modern analytic modeling techniques to improve HIV-prevention efforts.

描述（由申请人提供）：该导师研究科学家职业发展奖将为 David Barker 博士提供重点培训，使他能够利用现代统计建模方法来确定有前途的干预领域，并与多学科团队合作，为青少年和年轻人实施有效的艾滋病毒预防计划。有效传播现有预防计划的一个挑战是对谁对特定计划做出反应或不做出反应的了解有限。向政策制定者和项目主管提供此类信息将有助于将现有的预防项目与目标人群的需求相匹配。要确定哪种预防计划最适合哪些青年亚群体，需要复杂的统计模型和大量样本来识别和描述亚群体。跨研究结合是增加单个试验样本量的一种经济高效的方法。然而，由于研究设计方式以及关键结果收集、分析和解释方式的差异，合并数据会带来复杂性。拟议的研究结合了美国国立卫生研究院资助的五项针对有心理健康问题的青少年艾滋病毒预防项目试验的数据，以比较这些项目的功效，并确定哪些青少年对当前项目有反应或没有反应。拟议的研究帮助巴克博士实现他的职业和培训目标：(1) 学习现代建模方法来解决组合多个数据集时出现的复杂数据结构，(2) 学习在整合多个临床试验数据时得出因果推论的方法，(3) 学习比较未在“头对头”试验中测试的预防计划的功效的方法，(4) 将他在艾滋病毒风险预防方面的培训扩展到关键领域 美国国家艾滋病毒/艾滋病战略中确定的弱势群体，即物质使用群体和性少数群体，(5) 制定一项研究计划，利用现有数据确定有希望改善预防工作的领域，以及 (6) 与参与艾滋病毒预防的著名科学家合作，开发高质量的研究手稿和资助。拟议研究的具体目标是（1）建立一个数据库，将来自 5 项 NIH 资助的前瞻性艾滋病毒预防试验的数据联系起来，（2）通过联合建模青少年性风险行为的多个维度，对 5 项试验进行一致的分析，（3）比较当前针对有心理健康问题的青少年的预防计划的有效性，以及（4）识别并描述有心理健康问题的青少年亚组 对每种预防方法做出了回应或没有回应。这些目标将通过使用通过 K23 机制学到的技能来解决组合多个预防试验数据的分析复杂性来实现。培训将包括教学课程、研讨会以及现代分析方法和艾滋病预防专家团队的指导。指导将包括量身定制的阅读作业、定期面对面会议、指导研究以及合作项目和手稿。通过该 K23 应用程序接受的培训将使 Barker 博士能够与著名的艾滋病毒预防科学家合作，开展资助研究，重点是利用现代分析建模技术来改善艾滋病毒预防工作。