Comparative Efficacy of HIV-Prevention among Youth with Mental Health Needs

有心理健康需求的青少年艾滋病毒预防的比较效果

• 批准号: 9026651
• 负责人: DAVID Heaton BARKER
• 金额: $ 16.96万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9026651
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adolescence; Adolescent; Adolescent Risk Behavior; Adolescent and Young Adult; Adolescent sexual risk; Affect; Age; Alcohol or Other Drugs use; Ambulatory Care; Area; Attention; Behavior; Behavior assessment; Behavior monitoring; Behavioral; Characteristics; Child; Child Rearing; Clinical; Clinical Trials; Collaborations; Complex; Data; Data Set; Databases; Dimensions; Educational workshop; Emotional; Family Process; Foundations; Funding; Future; Goals; Grant; HIV; HIV prevention trial; HIV risk; Head; Health; Hospitals; Individual; Intervention; K-Series Research Career Programs; Learning; Learning Skill; Link; Manuscripts; Measurement; Measures; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modeling; Outcome; Policy Maker; Population; Positioning Attribute; Preparation; Prevention; Prevention approach; Prevention program; Prevention strategy; Prevention trial; Process; Psychopathology; Reading; Research; Research Design; Resources; Rhode Island; Risk; Risk Behaviors; Risk Factors; Safe Sex; Same-sex; Sample Size; Sampling; Schools; Scientist; Sex Behavior; Sexual Partners; Signal Transduction; Skills Development; Statistical Models; Structure; Subgroup; Target Populations; Techniques; Testing; Therapeutic; Training; United States; United States National Institutes of Health; Universities; Vulnerable Populations; Work; Youth; adolescent HIV prevention; adolescent substance use; base; career; communication behavior; comparative efficacy; cost effective; design; efficacy research; emotion regulation; experience; family management; follow-up; improved; learning strategy; meetings; multidisciplinary; parent-adolescent communication; permissiveness; program dissemination; programs; prospective; sex risk; sexual debut; sexual minority; skill acquisition; skills; skills training; social; young adult

DESCRIPTION (provided by applicant): This Mentored Research Scientist Career Development Award will provide Dr. David Barker with focused training to enable him to leverage modern statistical modeling methods in identifying promising areas of intervention, and to collaborate with multidisciplinary teams to implement effective HIV-prevention programs for adolescents and young adults. One challenge to the effective dissemination of existing prevention programs is the limited understanding of who responds or does not respond to a given program. Providing such information to policy makers and program directors will help match existing prevention programs to the needs of target populations. Identifying which prevention program works best for which subgroups of youth requires sophisticated statistical modeling and large samples to identify and describe the subgroups. Combining across studies is a cost-effective way to increase the sample size of individual trials. However, combining data introduces complexity due to differences in how studies are designed and in how key outcomes are collected, analyzed and interpreted. The proposed research combines data from five NIH-funded trials of HIV-prevention programs for youth with mental health concerns to compare the efficacy of the programs and identify which youth respond or do not respond to current programs. The proposed research assists Dr. Barker in achieving his career and training goals to: (1) learn modern modeling approaches to address complex data structures that arise when combining multiple datasets, (2) learn methods for drawing causal inferences when integrating data across multiple clinical trials, (3) learn methods to compare the efficacy of prevention programs not tested in a "head-to-head" trial, (4) extend his training in HIV-risk prevention to key vulnerable populations identified in the National HIV/AIDS Strategy for the United States, namely substance using populations and sexual minority populations, (5) develop a program of research that utilizes existing data to identify promising areas for improving prevention efforts, and (6) develop collaborations with prominent scientist involved in HIV-prevention to develop high-quality research manuscripts and grants. The specific aims of the proposed research are to (1) build a database that links data from 5 NIH-funded prospective HIV-prevention trials, (2) Apply consistent analyses across the 5 trials by jointly modeling the multiple dimensions of adolescent sexual risk behavior, (3) compare the efficacy of current prevention programs for youth with mental health concerns, and (4) Identify and describe subgroups of adolescents with mental health concerns who responded or did not respond to each prevention approach. These aims will be achieved by using the skills learned through this K23 mechanism to address the analytic complexities of combining data across multiple prevention trials. Training will include a combination of didactic coursework, workshops, and mentoring by a team of experts in modern analytic approaches and HIV-prevention. The mentoring will include tailored reading assignments, regular face-to-face meetings, mentored research, and collaborative projects and manuscripts. The training received through this K23 application will place Dr. Barker in a position to collaborate with prominent HIV-prevention scientists in funded research focused on leveraging modern analytic modeling techniques to improve HIV-prevention efforts.

描述（由申请人提供）：这项指导研究科学家职业发展奖将为David Barker博士提供重点培训，使他能够利用现代统计建模方法确定有前途的干预领域，并与多学科团队合作，为青少年和年轻人实施有效的艾滋病毒预防计划。有效传播现有预防规划的一个挑战是，人们对哪些人对某一规划作出反应或不作出反应的了解有限。向决策者和项目主管提供这类信息将有助于使现有的预防项目与目标人群的需求相匹配。确定哪个预防项目对哪个青少年亚群体最有效，需要复杂的统计模型和大样本来确定和描述这些亚群体。跨研究合并是增加单个试验样本量的一种经济有效的方法。然而，由于研究的设计方式以及收集、分析和解释关键结果的方式存在差异，合并数据会带来复杂性。这项拟议的研究结合了美国国立卫生研究院资助的五项针对青少年心理健康问题的艾滋病预防项目的试验数据，以比较这些项目的效果，并确定哪些青少年对当前的项目有反应，哪些没有反应。拟议的研究有助于Barker博士实现他的职业和培训目标：(1)学习现代建模方法，以解决组合多个数据集时出现的复杂数据结构；(2)学习在整合多个临床试验数据时得出因果推论的方法；(3)学习比较未在“面对面”试验中测试的预防方案的效果的方法；(4)将他在艾滋病毒风险预防方面的培训扩展到美国国家艾滋病毒/艾滋病战略中确定的关键弱势群体。(5)制定一项研究计划，利用现有数据确定有希望改善预防工作的领域；(6)与参与艾滋病毒预防的知名科学家开展合作，开发高质量的研究手稿和资助。该研究的具体目的是：(1)建立一个数据库，将nih资助的5项前瞻性hiv预防试验的数据联系起来；(2)通过联合建模青少年性风险行为的多个维度，对5项试验进行一致性分析；(3)比较当前针对有心理健康问题的青少年的预防项目的效果。(4)确定并描述有心理健康问题的青少年亚群体，他们对每种预防方法有反应或没有反应。这些目标将通过使用从K23机制中学到的技能来实现，以解决跨多个预防试验合并数据的分析复杂性。培训将包括教学课程、讲习班以及现代分析方法和艾滋病毒预防专家小组的指导。指导将包括量身定制的阅读作业、定期面对面会议、指导研究、合作项目和手稿。通过K23应用程序接受的培训将使Barker博士能够与杰出的艾滋病毒预防科学家合作，进行资助研究，重点是利用现代分析建模技术来改善艾滋病毒预防工作。