Investigating the gene and gene expression differences in the cells that drive leukemia development and relapse in children with AML

研究驱动 AML 儿童白血病发展和复发的细胞中的基因和基因表达差异

• 批准号: nhmrc : GNT1054482
• 负责人: Dr Elizabeth Kruse
• 金额: $ 38.86万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-gene-gene-children-aml/1344570
• 关键词: Investigating; gene; expression; differences; cells

Current treatments for AML are initially effective at killing the majority of leukemic cells, but the disease often comes back (relapses) due to rare cells that escape treatment and can regenerate the cancer (called leukemic stem cells or LSC for short). This project aims to determine if an individual patient has one, or many kinds of LSC and which kind of LSC is most likely to cause relapse. We believe that this knowledge will lead to new treatments that can target the cells that cause relapse.

目前的AML治疗最初有效地杀死了大多数白血病细胞，但由于罕见的细胞逃避治疗并可以再生癌症（称为白血病干细胞或简称LSC），这种疾病经常复发（复发）。该项目旨在确定个体患者是否患有一种或多种LSC，以及哪种LSC最有可能导致复发。我们相信，这些知识将导致新的治疗方法，可以针对导致复发的细胞。