Effects of Hurricane Sandy on the Respiratory and Mental Health of WTC Responders

桑迪飓风对世贸中心救援人员呼吸和心理健康的影响

• 批准号: 8662274
• 负责人: Adam Gonzalez
• 金额: $ 17.57万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8662274
• 关键词: Affect; Area; Blood specimen; Clinical; Communities; Complex; Data; Databases; Disasters; Dust; Electricity; Environmental Exposure; Exposure to; Floods; Health; Home environment; Hurricane; Hypersensitivity; Interview; Investigation; Laboratories; Learning; Left; Life; Long Island; Lung diseases; Mediating; Mental Health; Molds; Monitor; New York; Patient Self-Report; Population; Populations at Risk; Post-Traumatic Stress Disorders; Preventive Intervention; Pulmonary function tests; Respiratory physiology; Risk; Risk Factors; Sampling; Serum; Skin; Spirometry; Structure; Survivors; Symptoms; Testing; Toxic Environmental Substances; Toxicant exposure; Vulnerable Populations; Woman; World Trade Center disaster; cohort; depressive symptoms; design; experience; insight; longitudinal database; men; metropolitan; physical conditioning; programs; psychologic; psychological trauma; public health relevance; respiratory; response; screening

DESCRIPTION (provided by applicant): Hurricane Sandy resulted in the devastation of many communities in New York. In particular, Long Island experienced major flooding and powerful winds that left many without electricity for weeks, destroyed homes, and left behind mold and other environmental toxins. One of the most vulnerable groups living in these highly affected areas is responders to the attacks on the World Trade Center (WTC) on September 11, 2001 (9/11), many of whom continue to be active responders and, have persistent respiratory and psychological problems, or both, as a result of their response to 9/11. The Stony Brook WTC Health Program provides yearly health monitoring and treatment for WTC-related conditions for 7,000 WTC responders. Each year we systematically assess physical and mental health conditions, which we have been tracking in our cohort for the past eight years. Immediately after Hurricane Sandy, we began screening for Hurricane Sandy-related exposures. WTC responders exposed to this disaster may be particularly at-risk for new or exacerbation of health problems. The overall objective of the proposed study is to evaluate levels of exposure to environmental toxins and psychological trauma as a result of Hurricane Sandy and their effects on respiratory and mental health in a sample of 550 WTC responders from highly affected areas. The specific aims are to: (1) evaluate the impact of the disaster on WTC responders by examining changes from pre to post hurricane Sandy, in respiratory symptoms, lung functioning, and PTSD and depression symptoms; (2) document exposure to environmental toxins (i.e., mold and dust) and psychological trauma, and evaluate the impact of these exposures on respiratory symptoms, lung functioning, and mental health; (3) determine whether post-Hurricane Sandy PTSD symptoms are a risk factor for post disaster respiratory symptoms and lung functioning, and if PTSD mediates the impact of toxic exposures on respiratory health. We will use multimodal assessments including self-report, structured clinical interviews, and skin and serum allergy testing. By utilizing pre-Hurricane Sandy health data, we will be able to identify risk factors for post- disaster physical and mental health problems. This study will also provide translational value by furthering our understanding how respiratory disease and PTSD interact with one another. Thus, the current investigation offers a unique scientific opportunity to learn about the sequelae of Hurricane Sandy in an at-risk population and possible avenues for intervention and prevention.

描述（由申请人提供）：桑迪飓风导致纽约许多社区的破坏。特别是，长岛经历了重大的洪水和强大的风，使许多人无电数周，摧毁了房屋，并留在了霉菌和其他环境毒素的后面。居住在这些受影响的地区的最脆弱的团体之一是2001年9月11日（9/11）对世界贸易中心（WTC）的袭击者的反应者，其中许多人继续是积极的反应者，并且由于他们对9/11的反应而存在持续的呼吸和心理问题，或两者兼而有之。 Stony Brook WTC健康计划为7,000名WTC响应者提供了与WTC相关条件的年度健康监测和治疗。每年，我们都会系统地评估身体和心理健康状况，在过去的八年中，我们一直在研究中一直在跟踪。桑迪飓风过后，我们立即开始放映与飓风桑迪相关的暴露。暴露于这场灾难的WTC响应者可能特别会对健康问题进行新的或加剧的健康问题。 拟议的研究的总体目的是评估由于飓风桑迪（Sandy）及其对呼吸道和心理健康的影响，在来自受影响高的地区的550个WTC响应者样本中，由于飓风sandy及其对呼吸和心理健康的影响。具体目的是：（1）通过检查呼吸症状，肺部功能，PTSD和抑郁症状的变化来评估灾难对WTC响应者的影响； （2）记录暴露于环境毒素（即霉菌和灰尘）和心理创伤的情况，并评估这些暴露对呼吸症状，肺功能和心理健康的影响； （3）确定后紫色的Sandy PTSD症状是否是灾害后呼吸道症状和肺功能的危险因素，以及PTSD是否介导了毒性暴露对呼吸健康的影响。 我们将使用多模式评估，包括自我报告，结构化临床访谈以及皮肤和血清过敏测试。通过利用赫鲁里奇砂质健康数据，我们将能够确定风险因素 灾难后身心健康问题。这项研究还将通过进一步了解呼吸道疾病和PTSD相互作用来提供翻译价值。因此，当前的调查提供了一个独特的科学机会，可以在高危人群中了解飓风桑迪的后遗症，并可能用于干预和预防。

项目成果

Occupational Lung Diseases among Soldiers Deployed to Iraq and Afghanistan.

• DOI: 10.4172/2329-6879.1000117
• 发表时间: 2013-01-01
• 期刊: Occupational medicine & health affairs
• 作者: Szema, Anthony M

Emerging Novel Therapies for Heart Failure.

• DOI: 10.4137/cmc.s29735
• 发表时间: 2015
• 期刊: Clinical Medicine Insights. Cardiology
• 作者: Szema AM;Dang S;Li JC
• 通讯作者: Li JC

Iraq dust is respirable, sharp, and metal-laden and induces lung inflammation with fibrosis in mice via IL-2 upregulation and depletion of regulatory T cells.

伊拉克粉尘可吸入、锋利且富含金属，可通过 IL-2 上调和调节性 T 细胞耗竭而诱发小鼠肺部炎症和纤维化。

• DOI: 10.1097/jom.0000000000000119
• 发表时间: 2014
• 期刊: Journal of occupational and environmental medicine
• 影响因子: 3.2
• 作者: Szema,AnthonyM;Reeder,RichardJ;Harrington,AndreaD;Schmidt,Millicent;Liu,Jingxuan;Golightly,Marc;Rueb,Todd;Hamidi,SayyedA
• 通讯作者: Hamidi,SayyedA