The role of the Ras signalling molecule, C3G, in the interaction of neural precursor cells and their environment

Ras 信号分子 C3G 在神经前体细胞与其环境相互作用中的作用

• 批准号: nhmrc : 461215
• 负责人: A/Pr Anne Voss
• 金额: $ 21.3万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ras-signalling-cells-environment/101506
• 关键词: role; Ras; signalling; molecule; C3G

Developmental brain disorders affect 1-3% of the population. The mental retardation disease spectrum includes neuronal migration disorders and neural precursor proliferation disorders. We propose to study a molecular mechanism regulating neuronal migration, survival and proliferation. We have identified a protein, C3G, which is essential for three aspects of nervous system development: (A) C3G limits neural precursor cell proliferation. (B) C3G is essential for neuronal survival. (C) C3G is crucial for neuronal migration. C3G acts in a cascade of proteins, known as the Ras signalling pathway, which transmits signals from the extracellular environment into the cell nucleus to elicit appropriate responses of the cell to cues from the outside. We will identify proteins that, together with C3G, affect the important processes of neural precursor proliferation, and neuron survival and migration. This project will fully characterise a key regulatory mechanism of cellular processes crucial to the development of normal intelligence.

大脑发育障碍影响了1-3%的人口。精神发育迟滞疾病谱系包括神经元迁移障碍和神经前体增殖障碍。我们建议研究调控神经元迁移、存活和增殖的分子机制。我们已经确定了一种蛋白质C3G，它对神经系统发育的三个方面至关重要：(a) C3G限制神经前体细胞的增殖。(B) C3G对神经元存活至关重要。(C) C3G对神经元迁移至关重要。C3G在一系列蛋白质中起作用，被称为Ras信号通路，它将细胞外环境的信号传递到细胞核，从而引发细胞对外界信号的适当反应。我们将确定与C3G一起影响神经前体增殖和神经元存活和迁移的重要过程的蛋白质。该项目将充分表征对正常智力发展至关重要的细胞过程的关键调节机制。