Ohio State Neuroscience Centr Core

核心B：遗传学核心 这个核心的目的是为转基因小鼠和斑马鱼的研究提供支持。这一核心将促进目前由NINDS资助的研究，并促进使用不同动物模型系统的不同研究人员之间的协同互动。这种支持将通过补贴成本并提供先进的基因组编辑服务和水产养殖服务，使所有研究人员受益。遗传学核心有两个组成部分，每个组成部分都有自己的教员主任。 I.转基因小鼠核心 概述 这个核心的目的是支持新的小鼠模型的开发，这些模型将促进NINDS资助的研究人员，并刺激俄亥俄州立大学神经科学中心的PI之间的协同互动。因为Core将补贴制造转基因和基因敲除小鼠的成本，它将支持新的研究人员开发否则可能成本高昂的小鼠模型。这种支持将通过补贴的方式提供 产生转基因和基因敲除小鼠品系的成本，以及在小鼠品系的初始扩展和特征阶段补贴每日费用。在赠款的4.5年中，使用Core Support产生了43只转基因小鼠，使四名PI(Oberdick，Burghes，Obrietan，Yoon)受益。这一核心部件在12篇论文中被引用，并导致了两个新的R01。预计更新的需求为42个 转基因和10次击倒，使10名PI受益。因此，这是一个有价值的、富有成效的核心。

CORE B: GENETICS CORE The purpose of this Core is to provide support for transgenic mouse and zebrafish research. This Core will facilitate current NINDS-funded research and stimulate synergistic Interactions between diverse Investigators using different animal model systems. This support will benefit all investigators by subsidizing costs and providing advanced genome editing services and aquaculture services. The Genetics Core has two components, each with its own faculty Director. I. Transgenic Mice Core Overview The aim of this Core is to support the development of novel mouse models that will facilitate NINDS-funded researchers and stimulate synergistic interactions between Pis in the OSU Neuroscience Center. Because the Core will subsidize the cost of making transgenic and knockout mice, it will support new investigators to develop mouse models which otherwise could be cost prohibitive. This support will be provided by subsidizing costs of generating transgenic and knockout mouse lines and subsidizing the per diems during the initial expansion and characterization phase of the mouse line. Over the 4.5 years of the grant 43 transgenic mice were generated using Core Support benefiting four Pis (Oberdick, Burghes, Obrietan, Yoon). This Core component was cited in twelve papers and led to two new R01s. The projected need for the renewal is forty two transgenics and ten knock outs benefiting ten Pis. Thus, this is a valued, productive Core.