Investigating the mechanism and consequences of cytotoxic lymphocyte detachment

研究细胞毒性淋巴细胞脱离的机制和后果

• 批准号: nhmrc : 1104801
• 负责人: Dr Misty Jenkins
• 金额: $ 28.84万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-mechanism-consequences-lymphocyte-detachment/662783
• 关键词: Investigating; mechanism; consequences; cytotoxic; lymphocyte

Killer cells are white blood cells that destroy cancerous cells. To move to their next target they must quickly detach from a dying target. Failure of detachment results in excessive inflammation and tumour escape. This project will discover the detachment signals required to ‘release’ a locked-on killer cell. This will lead to a deeper understanding of immune pathology and new ways of treating cancer.

杀伤细胞是白细胞，可以摧毁癌细胞。为了移动到下一个目标，它们必须迅速脱离垂死的目标。脱离失败导致过度炎症和肿瘤逃逸。这个项目将发现“释放”一个锁定的杀手细胞所需的分离信号。这将导致对免疫病理和治疗癌症的新方法有更深的了解。