Investigating the delivery of cytotoxic T cell lytic granules and the microenvironment of the immunological synapse

研究细胞毒性 T 细胞裂解颗粒的递送和免疫突触的微环境

• 批准号: nhmrc : 567082
• 负责人: Dr Misty Jenkins
• 金额: $ 23.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-delivery-cytotoxic-immunological-synapse/116044
• 关键词: Investigating; delivery; cytotoxic; cell; lytic

T cells recognise infected or cancer cells and eliminate them from the body. They kill their targets by tightly attaching and releasing toxic proteins, which cause the target to undergo cell suicide. This research will use high resolution imaging to investigate the environment of the synapse between the two cells and understand parameters required for the delivery of a lethal hit. This will provide powerful insights into the working of the cell, and may identify novel intervention targets

T 细胞识别感染细胞或癌细胞并将其从体内清除。它们通过紧密附着和释放有毒蛋白质来杀死目标，从而导致目标发生细胞自杀。这项研究将使用高分辨率成像来研究两个细胞之间突触的环境，并了解致命打击所需的参数。这将为细胞的工作提供强有力的见解，并可能确定新的干预目标