Anti-counterfeit edible integral lens array for pharmaceuticals

药品防伪可食用整体透镜阵列

• 批准号: 8727297
• 负责人: JAY E STOCKLEY
• 金额: $ 22.2万
• 依托单位: BOULDER NONLINEAR SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727297
• 关键词: Anti; counterfeit; edible; integral; lens

DESCRIPTION (provided by applicant): Owing to the high cost of pharmaceuticals, there has become an ever increasing incidence of drug counterfeiting which has entered the market place. These counterfeit products represent significant danger to the public as it denies them safe access to needed medications. Current technologies to thwart counterfeiters include special packaging labels, ensuring lot and source of drug. However, these packages do not prevent refilling of empty bottles with counterfeit dosage forms. As an increased measure to prevent counterfeiting, the proposed effort will demonstrate the scalable manufacturability of a "per tablet" 3-D serial number labeling process. In Phase I we demonstrated UV writing to onto commercially available edible ink deposited on edible paper through an integral edible lens array. In addition, we demonstrated the ability of the spatial light modulator to project simple do-matrix patterns, relay an image, or if required, to produce a detailed holographic projection. This flexibility, along with the added capability of the lens arrays, provides a matrix of choices for te level of complexity of encoded information which itself relates to the degree of difficulty in manufacturing and of course the associated cost of protecting the pharmaceutical. This will provide the industry with a sliding scale of capabilities in terms of information encoding. Everything from simple patterns to enable traceability of common over the shelf and well-established drugs to more complex encoded information to protect high end pharmaceuticals that are more likely to be the target of counterfeiting attempts would be available. During Phase II we will study the trade-offs in manufacturability and cost to develop a variable "custom" manufacturing process that would including everything from simple marking to 3-D imaging using lens arrays or even constructing full holograms.

描述(申请人提供)：由于药品价格高昂，进入市场的假冒药品的发生率越来越高。这些假冒产品给公众带来了极大的危险，因为它使他们无法安全地获得所需的药物。目前打击造假者的技术包括特殊的包装标签，确保药品的批次和来源。然而，这些包装并不能防止用假冒剂型重新填充空瓶子。作为一项加强防止假冒的措施，拟议中的努力将展示“每片”3-D序列号标签过程的可扩展可制造性。在第一阶段，我们演示了通过集成的可食用透镜阵列将UV写入到存放在食用纸上的商业可用食用墨水上。此外，我们还演示了空间光调制器能够投影简单的DO矩阵图案，传递图像，或者如果需要，可以产生详细的全息投影。这 灵活性以及透镜阵列的附加能力为编码信息的复杂性水平提供了一个选择矩阵，其本身与制造的困难程度以及保护药物的相关成本有关。这将为该行业在信息编码方面提供不断变化的能力。从简单的模式到实现货架上常见药品和成熟药品的可追溯性，到更复杂的编码信息以保护更有可能成为假冒企图目标的高端药品，一切都将可用。在第二阶段，我们将研究在可制造性和成本方面的权衡，以开发一种可变的“定制”制造工艺，包括从简单标记到使用透镜阵列的3D成像，甚至构建完整全息图。