Anti-counterfeit edible integral lens array for pharmaceuticals

药品防伪可食用整体透镜阵列

• 批准号: 8727297
• 负责人: JAY E STOCKLEY
• 金额: $ 22.2万
• 依托单位: BOULDER NONLINEAR SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727297
• 关键词: Anti; counterfeit; edible; integral; lens

DESCRIPTION (provided by applicant): Owing to the high cost of pharmaceuticals, there has become an ever increasing incidence of drug counterfeiting which has entered the market place. These counterfeit products represent significant danger to the public as it denies them safe access to needed medications. Current technologies to thwart counterfeiters include special packaging labels, ensuring lot and source of drug. However, these packages do not prevent refilling of empty bottles with counterfeit dosage forms. As an increased measure to prevent counterfeiting, the proposed effort will demonstrate the scalable manufacturability of a "per tablet" 3-D serial number labeling process. In Phase I we demonstrated UV writing to onto commercially available edible ink deposited on edible paper through an integral edible lens array. In addition, we demonstrated the ability of the spatial light modulator to project simple do-matrix patterns, relay an image, or if required, to produce a detailed holographic projection. This flexibility, along with the added capability of the lens arrays, provides a matrix of choices for te level of complexity of encoded information which itself relates to the degree of difficulty in manufacturing and of course the associated cost of protecting the pharmaceutical. This will provide the industry with a sliding scale of capabilities in terms of information encoding. Everything from simple patterns to enable traceability of common over the shelf and well-established drugs to more complex encoded information to protect high end pharmaceuticals that are more likely to be the target of counterfeiting attempts would be available. During Phase II we will study the trade-offs in manufacturability and cost to develop a variable "custom" manufacturing process that would including everything from simple marking to 3-D imaging using lens arrays or even constructing full holograms.

描述（由申请人提供）：由于药品的高成本，进入市场的造成伪造的发病率越来越多。这些假冒产品对公众造成了重大危险，因为它可以安全使用所需的药物。挫败造假者的当前技术包括特殊包装标签，确保批量和药物来源。但是，这些包裹不会阻止用假剂量的空瓶重新装满空瓶。作为防止伪造的措施，提出的努力将证明“每平板电脑” 3-D序列号标记过程的可扩展性可扩展性。在第一阶段，我们证明了紫外线写作通过整体食用镜头阵列沉积在可食用纸上的市售可食用墨水上。此外，我们证明了空间照明调制器能够投射简单的DO-MATRIX模式，中继图像或需要产生详细的全息图投影的能力。这 灵活性以及镜头阵列的附加功能，为编码信息的复杂性水平提供了一个选择的矩阵，这些矩阵本身与制造业的难度有关，当然还有保护药品的相关成本。这将使行业在信息编码方面具有滑动功能。从简单的模式到能够在架子上和公认的药物到更复杂的编码信息，以保护高端药品的所有事物都可以提供伪造尝试的目标。在第二阶段，我们将研究制造可变的“自定义”制造过程的制造性和成本的权衡，该过程将使用镜头阵列，甚至构建完整的全息图。