Anti-counterfeit edible integral lens array for pharmaceuticals

药品防伪可食用整体透镜阵列

• 批准号: 8521837
• 负责人: JAY E STOCKLEY
• 金额: $ 29.77万
• 依托单位: BOULDER NONLINEAR SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8521837
• 关键词: Anti; counterfeit; edible; integral; lens

Project Summary/Abstract Owing to the high cost of pharmaceuticals, there has become an ever increasing incidence of drug counterfeiting which has entered the market place. These counterfeit products represent significant danger to the public as it denies them safe access to needed medications. Current technologies to thwart counterfeiters include special packaging labels, ensuring lot and source of drug. However, these packages do not prevent refilling of empty bottles with counterfeit dosage forms. As an increased measure to prevent counterfeiting, the proposed effort will demonstrate the scalable manufacturability of a "per tablet" 3-D serial number labeling process. In Phase I we demonstrated UV writing to onto commercially available edible ink deposited on edible paper through an integral edible lens array. In addition, we demonstrated the ability of the spatial light modulator to project simple dot-matrix patterns, relay an image, or if required, to produce a detailed holographic projection. This flexibility, along with the added capability of the lens arrays, provides a matrix of choices for the level of complexity of encoded information which itself relates to the degree of difficulty in manufacturing and of course the associated cost of protecting the pharmaceutical. This will provide the industry with a sliding scale of capabilities in terms of information encoding. Everything from simple patterns to enable traceability of common over the shelf and well-established drugs to more complex encoded information to protect high end pharmaceuticals that are more likely to be the target of counterfeiting attempts would be available. During Phase II we will study the trade-offs in manufacturability and cost to develop a variable "custom" manufacturing process that would including everything from simple marking to 3-D imaging using lens arrays or even constructing full holograms.

项目总结/摘要 由于药物的高成本， 假冒伪劣药品已经进入市场。这些假冒产品代表了 这对公众构成重大危险，因为它使他们无法安全地获得所需的药物。电流 技术，以阻止假冒包括特殊的包装标签，确保批次和来源 毒品然而，这些包装不能防止假冒伪劣产品重新填充空瓶 剂型。作为一项防止伪造的加强措施，拟议的努力将 展示了“每片”3-D序列号标签过程的可扩展制造性。 在第一阶段，我们展示了UV写入到沉积在 可食用纸通过一个整体的可食用透镜阵列。此外，我们还证明了 空间光调制器，用于投射简单点阵图案、中继图像，或者如果需要， 产生详细的全息投影。这种灵活性，连同沿着 透镜阵列，提供了一个矩阵的选择的复杂程度的编码信息 其本身涉及制造的难度以及当然相关的成本 来保护药品这将为该行业提供一个滑动规模的能力 在信息编码方面。从简单的模式到可追溯性， 常见的货架和完善的药物，以更复杂的编码信息， 保护更有可能成为假冒目标的高端药品 将可用。在第二阶段，我们将研究可制造性和成本的权衡， 开发一种可变的“定制”制造工艺， 标记到使用透镜阵列的3D成像或甚至构造全全息图。