Molecular and Soc. Determinants of Obesity and Metabolic Disorders in Youth

分子与社会。

基本信息

项目摘要

Obesity is recognized as the essential component of the metabolic syndrome, a pro-inflammatory state characterized by biomarkers of dyslipidemia, hypertension, central obesity, and elevated glucose. Scientists tend to identify only the genetic and behavioral antecedents of this pro-inflammatory state. Conversely, social and psychological researchers recognize a similar construct, allostatic load, also characterized by similar biomarkers. Differential environmental exposure to social stressors, i.e., allostatic load may lead to the pro-inflammatory state associated with metabolic syndrome . The challenge is to understand the link between obesity, metabolic and immunological abnormalities, and social stress. Recent research in adults indicates an increase in adiponectin after consumption of a Mediterranean diet high in fruits and vegetables. Consequently, greater access to fresh fruits and vegetables may contribute to increased adiponectin, reduced inflammation and a lower risk of obesity and metabolic disease. Our previous cross-sectional studies acknowledge that metabolic and pro-inflammatory mediators are over-expressed in youth prior to puberty. Prospective studies in developing children are proposed here to delineate the time course of obesity and metabolic dysfunction in relation to pro and anti-inflammatory markers. Correlating the molecular basis of obesity, one of the primary health disparities in the Deep South, with social determinants of health, e.g. maternal stress, neighborhood deterioration, food and physical activity environment and behavioral factors, e.g. diet and physical activity, assumes a complex, multidimensional effort involving a range of disciplines. Thus, in a multi-ethnic cohort of healthy youth we propose to; I. Examine the relationship of pro-and-antinflammatory SNPs with change in obesity and related metabolic biomarkers from pre-to-post-adolescence and further determine the mediating effect of the change in inflammatory markers during this same time period, II. Examine the contribution of social determinants (stress, food and physical activity environment) to the change in obesity, metabolic health and inflammation from pre-to-post adolescence after considering race, gender, maternal pregnancy weight, breastfeeding duration, diet and physical activity.
肥胖被认为是代谢综合征的重要组成部分,代谢综合征是一种促炎症状态 其特征在于血脂异常、高血压、向心性肥胖和葡萄糖升高的生物标志物。科学家 倾向于只确定这种促炎状态的遗传和行为前因。相反地, 社会和心理学研究人员认识到一个类似的结构,非稳态负荷,也具有以下特征: 相似的生物标志物。不同的环境暴露于社会压力,即,非稳态负荷可能导致 与代谢综合征相关的促炎状态。挑战在于理解 肥胖、代谢和免疫异常以及社会压力之间的联系。最近的成人研究 表明食用富含水果和蔬菜的地中海饮食后脂联素增加。 因此,更多地获得新鲜水果和蔬菜可能有助于增加脂联素, 减少炎症,降低肥胖和代谢疾病的风险。我们以前的横截面 研究承认,代谢和促炎介质在年轻人中过度表达, 青春期在此提出对发育中儿童的前瞻性研究,以描述肥胖的时间进程 以及与促炎和抗炎标志物相关的代谢功能障碍。关联分子基础 肥胖是南方腹地主要的健康差距之一,健康的社会决定因素,例如 母亲压力、邻里关系恶化、食物和体力活动环境以及行为因素, 例如饮食和身体活动,假设一个复杂的,多方面的努力,涉及一系列学科。 因此,在一个多种族的健康青年队列中,我们建议:检查促炎和抗炎的关系 从青春期前到青春期后肥胖和相关代谢生物标志物变化的SNP 并进一步确定在此期间炎症标志物变化的介导作用 期间,二。研究社会决定因素(压力、食物和身体活动环境)对 从青春期前到青春期后的肥胖、代谢健康和炎症变化, 种族、性别、孕妇怀孕体重、母乳喂养时间、饮食和体力活动。

项目成果

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MELINDA S SOTHERN其他文献

MELINDA S SOTHERN的其他文献

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{{ truncateString('MELINDA S SOTHERN', 18)}}的其他基金

Molecular and Soc. Determinants of Obesity and Metabolic Disorders in Youth
分子与社会。
  • 批准号:
    8579935
  • 财政年份:
    2012
  • 资助金额:
    $ 42.86万
  • 项目类别:
Metabolic Syndrome--Prepubertal African Amer./Caucasian
代谢综合症——青春期前的非洲裔美国人/白种人
  • 批准号:
    7933179
  • 财政年份:
    2009
  • 资助金额:
    $ 42.86万
  • 项目类别:
Metabolic Syndrome--Prepubertal African Amer./Caucasian
代谢综合症——青春期前的非洲裔美国人/白种人
  • 批准号:
    6875955
  • 财政年份:
    2005
  • 资助金额:
    $ 42.86万
  • 项目类别:
INSULIN SENSITIVITY IN AFRICAN AMERICAN & CAUCAIAN CHILDREN WITH LOW BIRTH WEIGH
非裔美国人的胰岛素敏感性
  • 批准号:
    7376339
  • 财政年份:
    2005
  • 资助金额:
    $ 42.86万
  • 项目类别:
Metabolic Syndrome--Prepubertal African Amer./Caucasian
代谢综合症——青春期前的非洲裔美国人/白种人
  • 批准号:
    7371142
  • 财政年份:
    2005
  • 资助金额:
    $ 42.86万
  • 项目类别:
Metabolic Syndrome--Prepubertal African Amer./Caucasian
代谢综合症——青春期前的非洲裔美国人/白种人
  • 批准号:
    7066655
  • 财政年份:
    2005
  • 资助金额:
    $ 42.86万
  • 项目类别:
Metabolic Syndrome--Prepubertal African Amer./Caucasian
代谢综合症——青春期前的非洲裔美国人/白种人
  • 批准号:
    7194328
  • 财政年份:
    2005
  • 资助金额:
    $ 42.86万
  • 项目类别:
Metabolic Syndrome--Prepubertal African Amer./Caucasian
代谢综合症——青春期前的非洲裔美国人/白种人
  • 批准号:
    7570635
  • 财政年份:
    2005
  • 资助金额:
    $ 42.86万
  • 项目类别:
Insulin Sensitivity in Children with low Birth Weight
低出生体重儿童的胰岛素敏感性
  • 批准号:
    6952674
  • 财政年份:
    2004
  • 资助金额:
    $ 42.86万
  • 项目类别:
Insulin Sensitivity in Children with low Birth Weight
低出生体重儿童的胰岛素敏感性
  • 批准号:
    6725626
  • 财政年份:
    2004
  • 资助金额:
    $ 42.86万
  • 项目类别:

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