Mentoring Program for Translational and Patient Oriented Research in AKI

AKI 转化和以患者为导向的研究指导计划

• 批准号: 8607937
• 负责人: Chirag R Parikh
• 金额: $ 17.92万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8607937
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; American; Area; Award; Biological Markers; Blood; Burn injury; Cardiac Surgery procedures; Cardiovascular Diseases; Cardiovascular system; Charge; Chronic Kidney Failure; Cirrhosis; Classification; Clinical; Clinical Research; Collaborations; Communities; Complex; Complication; Creatinine; Databases; Decision Making; Detection; Development; Diagnosis; Diagnostic tests; Disease; Disease Management; Educational Curriculum; Epidemiologic Methods; Epidemiologic Studies; Epidemiology; Ethics; Faculty; Fellowship; Functional disorder; Funding; Future; Gelatinase A; Goals; Grant; Hepatorenal Syndrome; Hour; Human; Incidence; Injury; Institution; Interleukin-18; Intervention; Kidney; Kidney Diseases; Kidney Transplantation; Knowledge; Lead; Medical; Medical Students; Mentors; Methods; Morbidity - disease rate; Myocardial Infarction; National Institute of Diabetes and Digestive and Kidney Diseases; National Research Service Awards; Nature; Nephrology; Oral; Outcome; Patients; Peer Review; Pharmaceutical Preparations; Physicians; Positioning Attribute; Principal Investigator; Proteins; Proteinuria; Proteomics; Public Health; Publications; Publishing; Recovery; Research; Research Activity; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Resources; Risk Factors; Safety; Sampling; Serum; Site; Societies; Structure; Techniques; Testing; Training; Translational Research; United States National Institutes of Health; Urine; Validation; Work; Writing; base; career; cohort; design; follow-up; hematopoietic cell transplantation; improved; innovation; interest; meetings; member; mortality; novel; patient oriented; patient oriented research; prognostic; programs; repaired; repository; research study; symposium

DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a common complication in hospitalized patients and is known to adversely impact short-term and long-term outcomes. The aim of the K24 grant is to provide support for Dr. Parikh's patient oriented research (POR) program and his mentoring activities for trainees interested in these research areas. Dr. Parikh is currently supported by federal grants as Principal Investigator for his research on the discovery and the validation of biomarkers in various settings of AKI. Dr. Parikh has also created the Translational Research Investigating Biomarker End-points (TRIBE) consortium for discovery and validation of biomarkers. These funded studies, as well as a wide variety of other multicenter collaborations through the TRIBE consortium, provide opportunities for training and independent research for Dr Parikh's trainees. Since the year 2000, Dr. Parikh has mentored over 20 residents or research fellows, and been senior author on over 40 peer-reviewed articles [with his mentee as the first author]. Three of his previous mentees are currently patient-oriented researchers and hold faculty positions at academic institutions. His mentees would be supported by a T32 National Research Service Award to the Section of Nephrology and other fellowship grants. As a part of the mentoring program, all trainees will complete 1) didactic training - course work in clinical research methodology; 2) a research project - a hypothesis-based project supervised by a Dr. Parikh and a multi-disciplinary faculty member; and 3) training in written and oral presentation by writing grants and presenting in conferences. All mentees will also be required to participate in a structured curriculum of ethics in clinical research. This K24 application also includes a new proposal for the discovery of biomarkers of recovery from AKI, using three different AKI cohorts and three complementary proteomic techniques.

描述（由申请人提供）：急性肾脏损伤（AKI）是住院患者的常见并发症，众所周知会对短期和长期结局产生不利影响。 K24赠款的目的是为Parikh博士以患者为导向的研究（POR）计划及其为对这些研究领域感兴趣的学员提供的指导活动提供支持。目前，Parikh博士得到了联邦补助金作为首席研究员的支持，以研究AKI的各种环境中的发现和验证生物标志物。 Parikh博士还创建了转化研究，研究了生物标志物（Tribe）的发现和验证生物标志物的联盟。这些资助的研究以及通过部落财团的各种其他多中心合作为帕里克博士的受训者提供了培训和独立研究的机会。自2000年以来，Parikh博士指导了20多名居民或研究研究员，并担任了40多个同行评审的文章的高级作家[与他的受训者成为第一作者]。他以前的三名受训者目前是以患者为导向的研究人员，并在学术机构担任教职员工职位。他的受训者将获得T32国家研究服务奖，授予肾脏科和其他奖学金赠款。作为指导计划的一部分，所有学员将完成1）教学培训 - 临床研究方法的课程工作； 2）研究项目 - 一个基于假设的项目，由帕里克博士和多学科教职员工监督； 3）通过书面和口头介绍的培训，在会议上写赠款和介绍。还将要求所有受训者参加临床研究中的结构化伦理课程。该K24应用程序还包括一项新的建议，以发现从AKI中发现生物标志物，使用三种不同的AKI队列和三种互补的蛋白质组学技术。