Mentoring Program for Translational and Patient Oriented Research in AKI

描述(由申请人提供)：急性肾损伤(AKI)是住院患者的常见并发症，已知会对短期和长期结果产生不利影响。K24基金的目的是为Parikh博士的以患者为导向的研究(POR)计划及其为对这些研究领域感兴趣的受训者提供指导活动提供支持。Parikh博士目前作为首席调查员受到联邦拨款的支持，他对AKI各种环境中生物标记物的发现和验证进行了研究。Parikh博士还创建了转译研究调查生物标记物终点(TRIBE)联盟，以发现和验证生物标记物。这些资助的研究，以及通过部落联盟进行的各种其他多中心合作，为Parikh博士的受训者提供了培训和独立研究的机会。自2000年以来，Parikh博士指导了20多名住院医生或研究员，并担任了40多篇同行评议文章的资深作者[他的导师是第一作者]。他之前的三名导师目前是以病人为导向的研究人员，并在学术机构担任教职。他的受训者将得到肾脏病学部T32国家研究服务奖和其他奖学金的支持。作为指导计划的一部分，所有受训人员将完成1)临床研究方法学的教学培训课程工作；2)研究项目--由一名Parikh博士和一名多学科教员监督的基于假设的项目；以及3)通过撰写助学金和在会议上发表演讲来进行书面和口头陈述的培训。所有受训者还将被要求参加临床研究中的伦理学结构化课程。这项K24应用还包括一项新的建议，即使用三种不同的AKI队列和三种互补的蛋白质组技术，发现从AKI中恢复的生物标记物。

DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a common complication in hospitalized patients and is known to adversely impact short-term and long-term outcomes. The aim of the K24 grant is to provide support for Dr. Parikh's patient oriented research (POR) program and his mentoring activities for trainees interested in these research areas. Dr. Parikh is currently supported by federal grants as Principal Investigator for his research on the discovery and the validation of biomarkers in various settings of AKI. Dr. Parikh has also created the Translational Research Investigating Biomarker End-points (TRIBE) consortium for discovery and validation of biomarkers. These funded studies, as well as a wide variety of other multicenter collaborations through the TRIBE consortium, provide opportunities for training and independent research for Dr Parikh's trainees. Since the year 2000, Dr. Parikh has mentored over 20 residents or research fellows, and been senior author on over 40 peer-reviewed articles [with his mentee as the first author]. Three of his previous mentees are currently patient-oriented researchers and hold faculty positions at academic institutions. His mentees would be supported by a T32 National Research Service Award to the Section of Nephrology and other fellowship grants. As a part of the mentoring program, all trainees will complete 1) didactic training - course work in clinical research methodology; 2) a research project - a hypothesis-based project supervised by a Dr. Parikh and a multi-disciplinary faculty member; and 3) training in written and oral presentation by writing grants and presenting in conferences. All mentees will also be required to participate in a structured curriculum of ethics in clinical research. This K24 application also includes a new proposal for the discovery of biomarkers of recovery from AKI, using three different AKI cohorts and three complementary proteomic techniques.