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The Effect of Vaporized Cannabis on Neuropathic Pain in Spinal Cord Injury

汽化大麻对脊髓损伤神经病理性疼痛的影响

基本信息

批准号：
8494032
负责人：
Holly Zhao
金额：
$ 33.36万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8494032
关键词：
Adverse effects Affect Affective Analgesics Antiemetics Area Attention Auditory Behavioral Biological Availability Breathing Cannabidiol Cannabinoids Cannabis Clinical Cognition Cross-Over Studies Development Digit structure Dissociation Distress Dose Double-Blind Method Effectiveness Emotional Euphoria Exposure to Funding Opportunities Goals Grant Heating Impaired cognition Impairment Individual Intoxication Learning Link Marijuana Measurement Measures Medicine Memory Mental Health Mental disorders Modality Modeling Moods Multiple Sclerosis National Institute of Drug Abuse Nociception Pain Pain Research Pain intensity Panic Patients Placebos Preparation Psychomotor Performance Randomized Reaction Time Relative (related person)Relaxation Reporting Sativex Schizophrenia Sedation procedure Sensory Sleep disturbances Smoking Spinal cord injury Tachycardia Techniques Testing Tetrahydrocannabinol Trail Making Test Vaporizer Variant Verbal Learning allodynia base cognitive change design heat stimulus human subject mechanical allodynia neuropsychological painful neuropathy processing speed response spinal cord injury pain suicidal risk

项目摘要

DESCRIPTION (provided by applicant): The present study will be designed to evaluate the analgesic effects of vaporized cannabis in patients with neuropathic pain due to spinal cord injury. A within-subject crossover study of the effects of cannabis (3.5% and 7.0% delta-9-THC) versus placebo on spontaneous and evoked pain will be performed. Both pain intensity and pain unpleasantness will be assessed to see if marijuana affects sensory-discriminative pain more or less than the motivational-affective component. If present, areas of mechanical allodynia will be assessed with repeated testing to determine the degree of the allodynia regression (if any) after inhaling cannabis via a vaporizer. Heat evoked pain will be studied using mild to moderately painful heat stimuli delivered to the painful area of the subject's body using an electronically controlled Peltier contact thermode via a Medoc TSA 2001 quantitative sensory tester. Neuropsychological functioning (attention, learning and memory, and psychomotor performance) will be evaluated with the Digit Symbol Modalities Test, the Hopkins Verbal Learning Test, the Grooved Pegboard Test Trail Making Test and the Paced Auditory Serial Addition Test (PASAT) before and after the administration of vaporized cannabis. Emotional responses will be evaluated using the Profile of Moods States. The degree of antinociception will then be compared with neuropsychological and mood effects of cannabis for a synopsis of the relative effectiveness (i.e., efficacy versus side-effects) of the doses employed. The major hypothesis will be that vaporized cannabis can induce antinociceptive changes in spontaneous and evoked pain in subjects with neuropathic pain. The second hypothesis will be that the higher dose of cannabis (7.0%) employed will induce the same or a greater degree of antinociception that is not independent of differences in mood, cognition, and psychomotor performance.

描述（由申请人提供）：本研究旨在评估汽化大麻对脊髓损伤引起的神经性疼痛患者的镇痛作用。将进行一项受试者内交叉研究，研究大麻（3.5% 和 7.0% delta-9-THC）与安慰剂对自发性疼痛和诱发性疼痛的影响。将评估疼痛强度和疼痛不愉快程度，看看大麻对感觉辨别疼痛的影响是否大于或小于对动机情感成分的影响。如果存在，将通过重复测试来评估机械异常性疼痛区域，以确定通过蒸发器吸入大麻后异常性疼痛消退的程度（如果有）。将使用电子控制的 Peltier 接触热电极通过 Medoc TSA 2001 定量感觉测试仪将轻度至中度疼痛的热刺激传递到受试者身体的疼痛区域，以研究热诱发的疼痛。在施用汽化大麻之前和之后，将通过数字符号模式测试、霍普金斯言语学习测试、凹槽钉板测试轨迹制作测试和节奏听觉串行添加测试（PASAT）来评估神经心理功能（注意力、学习和记忆以及精神运动表现）。将使用情绪状态概况来评估情绪反应。然后将镇痛程度与大麻的神经心理学和情绪影响进行比较，以概述所用剂量的相对有效性（即功效与副作用）。主要假设是汽化大麻可以引起神经性疼痛受试者自发性疼痛和诱发性疼痛的抗伤害变化。第二个假设是，使用较高剂量的大麻（7.0%）会引起相同或更大程度的镇痛作用，这种镇痛作用与情绪、认知和精神运动表现的差异无关。