Road to PET Image-Based On-line Proton Beam Range Measurement

基于 PET 图像的在线质子束射程测量之路

• 批准号: 8755657
• 负责人: YIPING SHAO
• 金额: $ 24.36万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-12 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8755657
• 关键词: Accounting; Advanced Malignant Neoplasm; Arts; Biological; Clinical; Clinical Research; Dose; Electronics; Ensure; Environment; Feasibility Studies; Foundations; Future; Geometry; Image; Imaging Phantoms; Lead; Measurement; Measures; Methods; Monitor; Nature; Neutrons; Noise; Normal tissue morphology; Outcome; Outcomes Research; Patients; Performance; Photons; Physiological; Positron-Emission Tomography; Proton Radiation; Protons; Radiation; Radiation therapy; Research; Research Project Grants; Solutions; Staging; System; Technology; Therapeutic; Therapeutic Index; Treatment Efficacy; Uncertainty; Work; anticancer research; base; cancer therapy; clinical application; clinically relevant; computerized data processing; data acquisition; detector; imaging modality; improved; in vivo imaging; innovation; irradiation; novel; physical property; proton beam; proton therapy; prototype; public health relevance; research study; scale up; simulation; statistics; technology development; treatment planning; tumor

DESCRIPTION (provided by applicant): Proton therapy (PT) is a latest state-of-art radiation therapy that can focus high level radiations to a small target. In principle, this unique physical property will allow PT to become a targeted therapy for significantly improved therapy efficacy while simultaneously reduced dose to normal tissues and thus reduced treatment complications. However, there are inherent physical uncertainties with PT which could make PT be harmful to a patient if the high dose were not delivered accurately. Clinicians have been forced to take overly conservative treatment approaches in restricting doses to the tumor in order to ensure sparing of normal tissues. It is critically important to overcome this impediment in order to dramatically enhance PT therapeutic outcomes and achieve the full clinical benefits. This research project aims to study the feasibility of an innovative PET image-based on-line verification of PT treatment plan instead of current off-line method. Conceptually, on-line approach will directly measure the potential deviation of actual setup and beam range (where beam will stop) from the treatment plan before the start of treatment, which will most effectively improve the targeting accuracy of PT and significantly enhance the PT therapy efficacy. Nevertheless, technically, it is challenging to achieve on-line measurement with two major technical questions have not been seriously investigated: Can a PET perform well in such proton radiation environment? Can on-line measurement with substantially lower count statistics provide the same level of measurement accuracy and precision as off-line measurement provides? This project attempts to answer these critical questions by pursuing three specific aims: scaling up an existing prototype PET to enable on-line imaging feasibility study; conducting phantom experimental studies under different proton radiation and PET imaging conditions to assess the feasibility of on-line measurement and PET performance; investigating the technical requirement to achieve on-line measurement under clinically relevant radiation and imaging conditions. The outcome of this research is expected to provide vital information on the feasibility of on-line measurement, gain the perspective of its potential for a high impact clinica application, and assist future technology development.

描述（由申请人提供）：质子治疗（PT）是一种最新最先进的放射治疗，可以将高水平辐射聚焦到小目标。原则上，这种独特的物理特性将使PT成为一种靶向治疗，可显着提高治疗效果，同时减少正常组织的剂量，从而减少治疗并发症。然而，PT 存在固有的物理不确定性，如果未能准确输送高剂量，PT 可能会对患者造成伤害。临床医生被迫采取过于保守的治疗方法来限制肿瘤的剂量，以确保正常组织不受影响。为了显着提高 PT 治疗效果并实现全部临床效益，克服这一障碍至关重要。该研究项目旨在研究基于 PET 图像的创新 PT 治疗计划在线验证替代当前离线方法的可行性。从概念上讲，在线方法将在治疗开始前直接测量实际设置和波束范围（波束将停止的位置）与治疗计划的潜在偏差，这将最有效地提高 PT 的靶向准确性，并显着提高 PT 治疗效果。然而，从技术上来说，实现在线测量具有挑战性，有两个主要技术问题尚未得到认真研究：PET能否在这样的质子辐射环境下表现良好？计数统计量低得多的在线测量能否提供与离线测量相同水平的测量准确度和精密度？该项目试图通过实现三个具体目标来回答这些关键问题：扩大现有原型 PET 以实现在线成像可行性研究；在不同质子辐射和PET成像条件下进行体模实验研究，以评估在线测量和PET性能的可行性；研究在临床相关辐射和成像条件下实现在线测量的技术要求。这项研究的结果预计将为在线测量的可行性提供重要信息，了解其在临床应用中具有高影响力的潜力，并协助未来的技术开发。