Advanced micro-PET/CT/RT System for Translational Radiation Oncology Applications

用于转化放射肿瘤学应用的先进微型 PET/CT/RT 系统

• 批准号: 9249366
• 负责人: YIPING SHAO
• 金额: $ 36.41万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9249366
• 关键词: 3-Dimensional; Adopted; Anatomy; Animal Disease Models; Animals; Beds; Biological; Biological Process; Caliber; Clinical; Clinical Research; Computer software; Data; Dose; Effectiveness; Electronics; Evaluation; Functional Imaging; Geometry; Goals; Human; Image; Imaging technology; Knowledge; Lead; Length; Logistics; Lung Neoplasms; Measures; Methods; Modeling; PET/CT scan; Performance; Phase; Photons; Play; Positioning Attribute; Positron-Emission Tomography; Problem Solving; Procedures; Protocols documentation; Radiation; Radiation Oncologist; Radiation Oncology; Radiation therapy; Radioisotopes; Research; Research Methodology; Research Personnel; Resolution; Risk; Roentgen Rays; Role; Scientist; Semiconductors; Source; System; Technology; Testing; Therapeutic Studies; Translating; Translational Research; Tumor Volume; Uncertainty; Variant; X-Ray Computed Tomography; base; cancer therapy; chemoradiation; clinical application; clinically relevant; data acquisition; design; detector; follow-up; image guided; image guided radiation therapy; image registration; imaging modality; imaging system; improved; in vivo; innovation; microCT; molecular imaging; new technology; novel; novel therapeutics; prevent; prototype; quantitative imaging; radiation effect; radiation response; research study; response; sensor; success; theories; thyroid neoplasm; treatment planning; tumor

Project Summary For radiation therapy (RT), the capability to precisely define and delivery radiations with the targeted distribution and dose level and to adapt the treatment plan based on the tumor biological response to RT is the key for any successful clinical therapy and translational research. For improving the current RT protocols and develop new novel RT strategies, it is critical to conduct translational RT researches with the technologies and procedures analogous to those applied in clinical RT practice so that the research methods and results are clinically relevant and can be effectively translated to clinical studies and applications. The goal of this project is to establish practical and advanced PET/CT image-guided radiation therapy (IGRT) capability for translational RT researches. The significance and impact of this project are very clear: it will overcome a critical technical obstacle to transform the current practice of RT research that is almost solely relied on anatomic CT images to the one guided by functional images with the knowledge of actual tumor biological status and function. The success of this project is expected to have lasting impact to improving and accelerating the translational RT research and profound benefits to enhancing the cancer treatment. The research aims to develop an advanced animal PET and integrate it with an existing micro-CT/RT, evaluate and improve the performance through experiments of phantom imaging and system modeling, and conduct pilot animal studies to test the capability PET/CT image-guided translational radiation oncology applications. The newly developed PET detector technologies will be applied to overcome technical challenges to achieve high sensitivity (23%) and high, uniform resolution (1 mm) required by the quantitative imaging of small size tumor for RT studies. The novel imaging technology to be developed by this project should also be practical so that it can be adopted for other micro-CT/RT systems without fundamental technical difficulties.

项目摘要 对于放射治疗(RT)，精确定义和提供目标辐射的能力 分布和剂量水平，并根据肿瘤对RT的生物学反应调整治疗计划 是任何成功的临床治疗和转化性研究的关键。用于改进当前的RT协议和 开发新的RT策略，关键是利用这些技术和技术进行翻译RT研究 类似于临床RT实践的程序，因此研究方法和结果是 具有临床相关性，并可有效地转化为临床研究和应用。这个项目的目标是 是建立实用和先进的PET/CT图像引导放射治疗(IGRT)能力，用于 翻译RT研究。这个项目的意义和影响是非常清楚的：它将克服一个关键的 改变目前几乎完全依赖解剖CT的RT研究的技术障碍 由功能图像引导的图像与具有实际肿瘤生物学状态的知识和 功能。预计该项目的成功将对改善和加快 翻译RT研究对提高癌症治疗水平具有深远的意义。这项研究旨在 开发先进的动物PET并将其与现有的Micro-CT/RT集成，评估和改进 通过体模成像和系统建模实验进行性能测试，并进行动物实验 以测试PET/CT图像引导平移放射肿瘤学应用的能力。新开发的 将应用PET探测器技术克服技术挑战，实现高灵敏度(23%) 小体积肿瘤的定量成像所需的高、均匀分辨率(1 Mm)。 该项目将开发的新的成像技术也应该是实用的，以便被采用 对于其他没有基本技术困难的微型CT/RT系统。