Training in Drug Abuse Related Research
药物滥用相关研究培训
基本信息
- 批准号:8874398
- 负责人:
- 金额:$ 9.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-07-01 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): This application requests a second renewal of five years of support for a successful interdisciplinary and translational training program in broad-based contemporary aspects of drug abuse research. Training the next generation of drug abuse researchers is critical to current and future public health challenges associated with drug addiction. The goal is to prepare trainees for productive and successful careers in drug abuse research. This program proposes to support 4 predoctoral and 2 postdoctoral trainees. We will vigorously recruit individuals from underrepresented minorities, disadvantaged backgrounds, and individuals with disabilities to increase diversity. This program provides a highly collaborative environment of interdisciplinary and translational training in drug abuse research. The 17 training faculty represent 7 academic units, have excellent training records, and will provide a rich interdisciplinary training environment. The program fosters the development of essential experimental and critical thinking skills, and provides the opportunity to gain an in depth understanding of and expertise in the interrelationships of the molecular/cellular aspects of receptors and signaling mechanisms involved in the neural and behavioral response to drugs of abuse and to become immersed in drug discovery and development in the pursuit of novel treatments for drug abuse. The overarching theme of the program is that drug addiction alters fundamental cellular and macromolecular processes resulting in long term changes in neural plasticity and behavior, which can be treated using pharmacotherapeutic intervention. The curriculum provides knowledge from physicochemical properties of molecules to structural biology, neurophysiology, neurochemistry, to animal and human behavior, with numerous opportunities for in depth study of focused areas of drug abuse research. The breadth of drug abuse research opportunities is enhanced by strong links to the University of Kentucky's (UK's) Center on Drug and Alcohol Research, the Center for Drug and Alcohol Research Translation, the Center for Clinical and Translational Science, the Center for Pharmaceutical Research and Innovation, the Laboratory on Human Behavioral Pharmacology and the Residential Research Facility. This program provides "value added" by serving as a linchpin to networking, interactions and collaborations with other trainees and training faculty focused on human behavioral and clinical aspects of drug abuse research and supported by a second T32 program directed by Dr. Craig Rush at UK. All positions in both T32 programs have been filled completely during the last funding period, indicative of the large number of promising trainees in drug abuse research at UK. UK provides solid infrastructure and institutional support, optimizing the training environment. The majority of program graduates continue to actively pursue drug abuse research and advance towards independent investigator status. In the upcoming funding period, we propose to continue our record of success and develop responsible and ethical drug abuse researchers, who will move the field of drug abuse forward.
描述(由申请人提供):本申请要求第二次续签五年的支持,以支持在药物滥用研究的广泛当代方面成功的跨学科和翻译培训计划。培训下一代药物滥用研究人员对于当前和未来与药物成瘾有关的公共卫生挑战至关重要。目标是使受训人员为在药物滥用研究方面的富有成效和成功的职业生涯做好准备。该计划拟支持4名博士前和2名博士后培训生。我们将积极招募来自代表性不足的少数民族,弱势背景和残疾人的个人,以增加多样性。该计划提供了一个高度协作的环境,在药物滥用研究的跨学科和翻译培训。17个培训教师代表7个学术单位,具有良好的培训记录,并将提供丰富的跨学科培训环境。该计划促进了必要的实验和批判性思维技能的发展,并提供了机会,以获得深入了解和专业知识的受体和信号传导机制的分子/细胞方面的相互关系参与滥用药物的神经和行为反应,并成为沉浸在药物发现和开发在追求药物滥用的新疗法。该计划的首要主题是药物成瘾改变了基本的细胞和大分子过程,导致神经可塑性和行为的长期变化,这可以通过药物干预来治疗。该课程提供了从分子的物理化学性质到结构生物学,神经生理学,神经化学,动物和人类行为的知识,并有许多机会深入研究药物滥用研究的重点领域。药物滥用研究机会的广度通过与肯塔基州大学(英国)药物和酒精研究中心,药物和酒精研究翻译中心,临床和转化科学中心,药物研究和创新中心,人类行为药理学实验室和住宅研究设施的紧密联系得到加强。该计划提供了“增值”作为一个关键的网络,互动和合作,与其他学员和培训教师专注于人类行为和药物滥用研究的临床方面,并由第二个T32计划的支持,由博士指导克雷格拉什在英国。在上一个供资期间,两个T32方案的所有职位都已全部填补,表明联合王国有大量有前途的药物滥用研究受训人员。英国提供坚实的基础设施和制度支持,优化培训环境。大多数课程毕业生继续积极从事药物滥用研究,并朝着独立调查员的地位前进。在即将到来的资助期间,我们建议继续我们的成功记录,并培养负责任和道德的药物滥用研究人员,他们将推动药物滥用领域的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Linda P Dwoskin其他文献
毒ガエルアルカロイドcis-195A, -211Aの全合成とその活性評価
毒蛙生物碱cis-195A、-211A的全合成及其活性评价
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
岡田卓哉;高島克輝;石村潤郷;呉乃朕;恒枝宏史;笹岡利安;山崎雄平;久保義行;細谷健一;Syed R Hussaini;Linda P Dwoskin;豊岡 尚樹 - 通讯作者:
豊岡 尚樹
Linda P Dwoskin的其他文献
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{{ truncateString('Linda P Dwoskin', 18)}}的其他基金
Kentucky Network for Innovation & Commercialization (“KYNETIC”)
肯塔基州创新网络
- 批准号:
10475211 - 财政年份:2019
- 资助金额:
$ 9.44万 - 项目类别:
Development of Novel Therapeutics for Methamphetamine Abuse
甲基苯丙胺滥用新疗法的开发
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10186610 - 财政年份:2018
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$ 9.44万 - 项目类别:
Development of Novel Therapeutics for Methamphetamine Abuse
甲基苯丙胺滥用新疗法的开发
- 批准号:
9750673 - 财政年份:2018
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$ 9.44万 - 项目类别:
Development of Antagonists for M5 Muscarinic Acetylcholine Receptor
M5毒蕈碱乙酰胆碱受体拮抗剂的研制
- 批准号:
7768413 - 财政年份:2009
- 资助金额:
$ 9.44万 - 项目类别:
Development of Novel Therapies or Methamphetamine Abuse
新疗法的开发或甲基苯丙胺滥用
- 批准号:
7829875 - 财政年份:2009
- 资助金额:
$ 9.44万 - 项目类别:
Nicotinic Receptor Regulation of Dopamine Transporter
多巴胺转运蛋白的烟碱受体调节
- 批准号:
6989377 - 财政年份:2005
- 资助金额:
$ 9.44万 - 项目类别:
Nicotinic Receptor Regulation of Dopamine Transporter
多巴胺转运蛋白的烟碱受体调节
- 批准号:
7140559 - 财政年份:2005
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$ 9.44万 - 项目类别:
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