Training in Drug Abuse Related Research

药物滥用相关研究培训

• 批准号: 9297250
• 负责人: Linda P Dwoskin
• 金额: $ 29.12万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9297250
• 关键词: Drug abuse; Research; Training

DESCRIPTION (provided by applicant): This application requests a second renewal of five years of support for a successful interdisciplinary and translational training program in broad-based contemporary aspects of drug abuse research. Training the next generation of drug abuse researchers is critical to current and future public health challenges associated with drug addiction. The goal is to prepare trainees for productive and successful careers in drug abuse research. This program proposes to support 4 predoctoral and 2 postdoctoral trainees. We will vigorously recruit individuals from underrepresented minorities, disadvantaged backgrounds, and individuals with disabilities to increase diversity. This program provides a highly collaborative environment of interdisciplinary and translational training in drug abuse research. The 17 training faculty represent 7 academic units, have excellent training records, and will provide a rich interdisciplinary training environment. The program fosters the development of essential experimental and critical thinking skills, and provides the opportunity to gain an in depth understanding of and expertise in the interrelationships of the molecular/cellular aspects of receptors and signaling mechanisms involved in the neural and behavioral response to drugs of abuse and to become immersed in drug discovery and development in the pursuit of novel treatments for drug abuse. The overarching theme of the program is that drug addiction alters fundamental cellular and macromolecular processes resulting in long term changes in neural plasticity and behavior, which can be treated using pharmacotherapeutic intervention. The curriculum provides knowledge from physicochemical properties of molecules to structural biology, neurophysiology, neurochemistry, to animal and human behavior, with numerous opportunities for in depth study of focused areas of drug abuse research. The breadth of drug abuse research opportunities is enhanced by strong links to the University of Kentucky's (UK's) Center on Drug and Alcohol Research, the Center for Drug and Alcohol Research Translation, the Center for Clinical and Translational Science, the Center for Pharmaceutical Research and Innovation, the Laboratory on Human Behavioral Pharmacology and the Residential Research Facility. This program provides "value added" by serving as a linchpin to networking, interactions and collaborations with other trainees and training faculty focused on human behavioral and clinical aspects of drug abuse research and supported by a second T32 program directed by Dr. Craig Rush at UK. All positions in both T32 programs have been filled completely during the last funding period, indicative of the large number of promising trainees in drug abuse research at UK. UK provides solid infrastructure and institutional support, optimizing the training environment. The majority of program graduates continue to actively pursue drug abuse research and advance towards independent investigator status. In the upcoming funding period, we propose to continue our record of success and develop responsible and ethical drug abuse researchers, who will move the field of drug abuse forward.

描述（由申请人提供）：本申请要求第二次续签五年的支持，以在药物滥用研究的广泛当代方面成功开展跨学科和转化培训计划。培训下一代药物滥用研究人员对于当前和未来与药物成瘾相关的公共卫生挑战至关重要。目标是让学员为药物滥用研究领域富有成效和成功的职业做好准备。该项目拟资助4名博士前培训生和2名博士后培训生。我们将大力招募来自代表性不足的少数群体、弱势背景和残疾人的个人，以增加多样性。该计划为药物滥用研究提供了一个高度协作的跨学科和转化培训环境。 17名培训师资代表7个学术单位，拥有优秀的培训记录，将提供丰富的跨学科培训环境。该计划促进基本实验和批判性思维技能的发展，并提供机会深入了解受体分子/细胞方面的相互关系和涉及滥用药物的神经和行为反应的信号机制，并沉浸在药物发现和开发中，以寻求药物滥用的新疗法。该计划的首要主题是药物成瘾改变了基本的细胞和大分子过程，导致神经可塑性和行为的长期变化，这可以通过药物治疗干预来治疗。该课程提供从分子的物理化学性质到结构生物学、神经生理学、神经化学、动物和人类行为的知识，并提供大量深入研究药物滥用研究重点领域的机会。与肯塔基大学（英国）药物和酒精研究中心、药物和酒精研究翻译中心、临床和转化科学中心、药物研究和创新中心、人类行为药理学实验室和住宅研究设施的密切联系增强了药物滥用研究机会的广度。该项目通过作为与其他学员和培训教员建立联系、互动和合作的关键来提供“增值”，重点关注药物滥用研究的人类行为和临床方面，并得到英国 Craig Rush 博士指导的第二个 T32 项目的支持。在上一个资助期内，两个 T32 项目的所有职位都已被完全填补，这表明英国在药物滥用研究方面有大量有前途的学员。英国提供坚实的基础设施和制度支持，优化培训环境。大多数项目毕业生继续积极从事药物滥用研究，并迈向独立调查员地位。在即将到来的资助期内，我们建议继续我们的成功记录，并培养负责任和有道德的药物滥用研究人员，他们将推动药物滥用领域的发展。